ロミデプシン (Synonyms: Romidepsin; FK 228; FR 901228; NSC 630176)

Name: Romidepsin
Brand: MedChemExpress
SKU: HY-15149
Rating: 5.0 (70 reviews)

製品番号: HY-15149 純度: 99.90%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC₅₀s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively. Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 128517-07-7

容量	価格（税別）	在庫状況	数量
1 mg	$132	在庫あり	Estimated Time of Arrival: December 31
5 mg	$300	在庫あり	Estimated Time of Arrival: December 31
10 mg	$480	在庫あり	Estimated Time of Arrival: December 31
25 mg	$768	在庫あり	Estimated Time of Arrival: December 31
50 mg	$1120	在庫あり	Estimated Time of Arrival: December 31
100 mg	$1620	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 70 publication(s) in Google Scholar

Other Forms of Romidepsin:

Romidepsin-d₇ お問い合わせ
Romidepsin (GMP) お問い合わせ

顧客検証

Cell Proliferation/Viability Assay

: Romidepsin purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2023 Mar 13;41(3):602-619.e11. [Abstract]; The triple combination of E + R + iC significantly decreases tumor volume compared with double combinations, in mice. E: enzalutamide (30 mg/kg; p.o.; single daily for 10 days); R: Romidepsin (0.3 mg/kg; i.p.; single daily for 10 days); iC: CXCR2 inhibitor.

: Romidepsin purchased from MedChemExpress. Usage Cited in: Commun Biol. 2021 Oct 29;4(1):1235. [Abstract]; TNBC model cells (MDA-MB-231 and BT-549) were treated with indicated HDACi (Vorinostat: 10 µM; Panobinostat: 1 µM; Romidepsin: 1 µM; Givinostat: 1 µM) for 24 h and expression of LIFR, p-STAT3(Y705), and STAT3 were determined using Western blotting.

: Romidepsin purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2018 Sep 13;14(9):e1007267. [Abstract]; Immunoblot analysis for vIL-6, ORF45, or actin is performed on lysates from BCBL-1 cells treated with NaB+TPA, Romidepsin or LBH589.

: Romidepsin purchased from MedChemExpress. Usage Cited in: Neurosci Lett. 2017 Jul 13:653:12-18. [Abstract]; Romidepsin increases histone acetylation in SH-SY5Y neuroblastoma cells. Western blots of pAcH3 and β-actin levels in SH-SY5Y cells cultured for 24 h with 0-40 nM of Romidepsin. 20 nM and 40 nM Romidepsin significantly increase the levels of pAcH3 relative to control, which is measured by densitometric quantification of pAcH3 protein levels relative to β-actin loading control.

HDAC アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC₅₀s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively^[1]. Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis^[2].

IC₅₀ & Target^[1]

HDAC1

36 nM (IC₅₀)

HDAC2

47 nM (IC₅₀)

HDAC4

510 nM (IC₅₀)

HDAC6

14000 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	2.6 nM Compound: 1, FK228	Growth inhibition of human A549 cells by sulforhodamine B colorimetric method Growth inhibition of human A549 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
A549	GI₅₀	2.6 nM Compound: 1; FK228	Growth inhibition of human A549 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human A549 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
A549	GI₅₀	2.6 nM Compound: 5, FK228	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 24589486]
A549	IC₅₀	0.025 μM Compound: FK228	Growth inhibition of human A549 cells Growth inhibition of human A549 cells	[PMID: 28814374]
ACHN	GI₅₀	20 nM Compound: 1, FK228	Growth inhibition of human ACHN cells by sulforhodamine B colorimetric method Growth inhibition of human ACHN cells by sulforhodamine B colorimetric method	[PMID: 23313638]
ACHN	GI₅₀	20 nM Compound: 1; FK228	Growth inhibition of human ACHN cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human ACHN cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
ACHN	GI₅₀	20 nM Compound: 5, FK228	Cytotoxicity against human ACHN cells by SRB assay Cytotoxicity against human ACHN cells by SRB assay	[PMID: 24589486]
DMS-114	GI₅₀	3.6 nM Compound: 1, FK228	Growth inhibition of human DMS114 cells by sulforhodamine B colorimetric method Growth inhibition of human DMS114 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
DMS-114	GI₅₀	3.6 nM Compound: 1; FK228	Growth inhibition of human DMS-114 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human DMS-114 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
DMS-114	GI₅₀	3.6 nM Compound: 5, FK228	Cytotoxicity against human DMS114 cells by SRB assay Cytotoxicity against human DMS114 cells by SRB assay	[PMID: 24589486]
DMS-273	GI₅₀	5.8 nM Compound: 1, FK228	Growth inhibition of human DMS273 cells by sulforhodamine B colorimetric method Growth inhibition of human DMS273 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
DMS-273	GI₅₀	5.8 nM Compound: 1; FK228	Growth inhibition of human DMS-273 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human DMS-273 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
DMS-273	GI₅₀	5.8 nM Compound: 5, FK228	Cytotoxicity against human DMS273 cells by SRB assay Cytotoxicity against human DMS273 cells by SRB assay	[PMID: 24589486]
DU-145	GI₅₀	2.55 nM Compound: 1, FK228	Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay	[PMID: 26331334]
DU-145	GI₅₀	6 nM Compound: 1, FK228	Growth inhibition of human DU145 cells by sulforhodamine B colorimetric method Growth inhibition of human DU145 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
DU-145	GI₅₀	6 nM Compound: 1; FK228	Growth inhibition of human DU-145 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human DU-145 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
DU-145	GI₅₀	6 nM Compound: 5, FK228	Cytotoxicity against human DU145 cells by SRB assay Cytotoxicity against human DU145 cells by SRB assay	[PMID: 24589486]
HCC 2998	GI₅₀	3.1 nM Compound: 1, FK228	Growth inhibition of human HCC2998 cells by sulforhodamine B colorimetric method Growth inhibition of human HCC2998 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
HCC 2998	GI₅₀	3.1 nM Compound: 1; FK228	Growth inhibition of human HCC 2998 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human HCC 2998 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
HCC 2998	GI₅₀	3.1 nM Compound: 5, FK228	Cytotoxicity against human HCC2998 cells by SRB assay Cytotoxicity against human HCC2998 cells by SRB assay	[PMID: 24589486]
HCT-116	GI₅₀	11.6 nM Compound: FK228	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 31057733]
HCT-116	GI₅₀	3.1 nM Compound: 1, FK228	Growth inhibition of human HCT116 cells by sulforhodamine B colorimetric method Growth inhibition of human HCT116 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
HCT-116	GI₅₀	3.1 nM Compound: 1; FK228	Growth inhibition of human HCT-116 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human HCT-116 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
HCT-116	GI₅₀	3.1 nM Compound: 5, FK228	Cytotoxicity against human HCT116 cells by SRB assay Cytotoxicity against human HCT116 cells by SRB assay	[PMID: 24589486]
HCT-116	IC₅₀	0.028 μM Compound: Romidepsin	Antiproliferative activity against human HCT116 cells assessed as cell viability incubated for 72 hrs by coulter counter method Antiproliferative activity against human HCT116 cells assessed as cell viability incubated for 72 hrs by coulter counter method	[PMID: 26481659]
HCT-116	IC₅₀	3 nM Compound: FK228	Antiproliferative activity against human HCT116 cells after 48 hrs in presence of DTT by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs in presence of DTT by MTT assay	[PMID: 25147612]
HCT-15	GI₅₀	450 nM Compound: 1, FK228	Growth inhibition of human HCT15 cells by sulforhodamine B colorimetric method Growth inhibition of human HCT15 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
HCT-15	GI₅₀	450 nM Compound: 1; FK228	Growth inhibition of human HCT-15 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human HCT-15 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
HCT-15	GI₅₀	450 nM Compound: 2; FK228	Cytotoxicity against human HCT-15 cells assessed as cell growth inhibition by sulforhodamine B colorimetric method Cytotoxicity against human HCT-15 cells assessed as cell growth inhibition by sulforhodamine B colorimetric method	[PMID: 34826681]
HCT-15	GI₅₀	450 nM Compound: 5, FK228	Cytotoxicity against human HCT15 cells by SRB assay Cytotoxicity against human HCT15 cells by SRB assay	[PMID: 24589486]
HEK293	CC₅₀	0.004 μM Compound: Romidepsin	Cytotoxicity against HEK293 cells assessed as reduction in cell growth incubated for 48 hrs by MTS assay Cytotoxicity against HEK293 cells assessed as reduction in cell growth incubated for 48 hrs by MTS assay	[PMID: 30973727]
HEK293	IC₅₀	<= 0.001 μM Compound: 11; FK228	Cytotoxicity against HEK293 cells after 48 hrs by resazurin assay Cytotoxicity against HEK293 cells after 48 hrs by resazurin assay	[PMID: 28241112]
HEK293	IC₅₀	<= 1 nM Compound: Romidepsin	Cytotoxicity against HEK293 cells after 48 hrs by resazurin dye based assay Cytotoxicity against HEK293 cells after 48 hrs by resazurin dye based assay	[PMID: 30245402]
HT-29	GI₅₀	3.3 nM Compound: 1, FK228	Growth inhibition of human HT-29 cells by sulforhodamine B colorimetric method Growth inhibition of human HT-29 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
HT-29	GI₅₀	3.3 nM Compound: 1; FK228	Growth inhibition of human HT-29 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human HT-29 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
HT-29	GI₅₀	3.3 nM Compound: 5, FK228	Cytotoxicity against human HT-29 cells by SRB assay Cytotoxicity against human HT-29 cells by SRB assay	[PMID: 24589486]
HepG2	CC₅₀	0.01 μM Compound: Romidepsin	Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by CellTiter-Glo assay Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by CellTiter-Glo assay	[PMID: 30973727]
HepG2	IC₅₀	2.4 ng/mL Compound: FK228; 2	Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 3 days by trypan blue assay Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 3 days by trypan blue assay	[PMID: 35586423]
IGROV-1	IC₅₀	0.08 μM Compound: Romidepsin	Antiproliferative activity against human IGROV1/Pt1 cells assessed as cell viability incubated for 72 hrs by coulter counter method Antiproliferative activity against human IGROV1/Pt1 cells assessed as cell viability incubated for 72 hrs by coulter counter method	[PMID: 26481659]
IGROV-1	IC₅₀	0.22 μM Compound: Romidepsin	Antiproliferative activity against human IGROV1 cells assessed as cell viability incubated for 72 hrs by coulter counter method Antiproliferative activity against human IGROV1 cells assessed as cell viability incubated for 72 hrs by coulter counter method	[PMID: 26481659]
KM12	GI₅₀	3.4 nM Compound: 1, FK228	Growth inhibition of human KM12 cells by sulforhodamine B colorimetric method Growth inhibition of human KM12 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
KM12	GI₅₀	3.4 nM Compound: 1; FK228	Growth inhibition of human KM12 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human KM12 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
KM12	GI₅₀	3.4 nM Compound: 5, FK228	Cytotoxicity against human KM12 cells by SRB assay Cytotoxicity against human KM12 cells by SRB assay	[PMID: 24589486]
LOX IMVI	GI₅₀	2.5 nM Compound: 1, FK228	Growth inhibition of human LOXIMVI cells by sulforhodamine B colorimetric method Growth inhibition of human LOXIMVI cells by sulforhodamine B colorimetric method	[PMID: 23313638]
LOX IMVI	GI₅₀	2.5 nM Compound: 1; FK228	Growth inhibition of human LOX IMVI cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human LOX IMVI cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
LOX IMVI	GI₅₀	2.5 nM Compound: 5, FK228	Cytotoxicity against human LOXIMVI cells by SRB assay Cytotoxicity against human LOXIMVI cells by SRB assay	[PMID: 24589486]
MCF7	GI₅₀	4.2 nM Compound: 1, FK228	Growth inhibition of human MCF7 cells by sulforhodamine B colorimetric method Growth inhibition of human MCF7 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
MCF7	GI₅₀	4.2 nM Compound: 1; FK228	Growth inhibition of human MCF7 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MCF7 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
MCF7	GI₅₀	4.2 nM Compound: 5, FK228	Cytotoxicity against human MCF7 cells by SRB assay Cytotoxicity against human MCF7 cells by SRB assay	[PMID: 24589486]
MCF7	IC₅₀	0.75 nM Compound: FK-228	Growth inhibition of MCF7 cells Growth inhibition of MCF7 cells	[PMID: 17958342]
MDA-MB-231	GI₅₀	11.5 nM Compound: FK228	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 31057733]
MDA-MB-231	GI₅₀	5.5 nM Compound: 1, FK228	Growth inhibition of human MDA-MB-231 cells by sulforhodamine B colorimetric method Growth inhibition of human MDA-MB-231 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
MDA-MB-231	GI₅₀	5.5 nM Compound: 1; FK228	Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
MDA-MB-231	GI₅₀	5.5 nM Compound: 5, FK228	Cytotoxicity against human MDA-MB-231 cells by SRB assay Cytotoxicity against human MDA-MB-231 cells by SRB assay	[PMID: 24589486]
MDA-MB-231	GI₅₀	9.7 nM Compound: 2	Antiproliferative activity against triple-negative human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay Antiproliferative activity against triple-negative human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay	[PMID: 33745280]
MKN-1	GI₅₀	3.2 nM Compound: 1, FK228	Growth inhibition of human MKN1 cells by sulforhodamine B colorimetric method Growth inhibition of human MKN1 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
MKN-1	GI₅₀	3.2 nM Compound: 1; FK228	Growth inhibition of human MKN-1 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MKN-1 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
MKN-1	GI₅₀	3.2 nM Compound: 5, FK228	Cytotoxicity against human MKN1 cells by SRB assay Cytotoxicity against human MKN1 cells by SRB assay	[PMID: 24589486]
MKN-28	GI₅₀	17 nM Compound: 1, FK228	Growth inhibition of human MKN28 cells by sulforhodamine B colorimetric method Growth inhibition of human MKN28 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
MKN-28	GI₅₀	17 nM Compound: 1; FK228	Growth inhibition of human MKN-28 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MKN-28 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
MKN-28	GI₅₀	17 nM Compound: 5, FK228	Cytotoxicity against human MKN28 cells by SRB assay Cytotoxicity against human MKN28 cells by SRB assay	[PMID: 24589486]
MKN-45	GI₅₀	14 nM Compound: 1, FK228	Growth inhibition of human MKN45 cells by sulforhodamine B colorimetric method Growth inhibition of human MKN45 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
MKN-45	GI₅₀	14 nM Compound: 1; FK228	Growth inhibition of human MKN-45 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MKN-45 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
MKN-45	GI₅₀	14 nM Compound: 5, FK228	Cytotoxicity against human MKN45 cells by SRB assay Cytotoxicity against human MKN45 cells by SRB assay	[PMID: 24589486]
MKN-7	GI₅₀	4.9 nM Compound: 1, FK228	Growth inhibition of human MKN7 cells by sulforhodamine B colorimetric method Growth inhibition of human MKN7 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
MKN-7	GI₅₀	4.9 nM Compound: 1; FK228	Growth inhibition of human MKN-7 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MKN-7 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
MKN-7	GI₅₀	4.9 nM Compound: 5, FK228	Cytotoxicity against human MKN7 cells by SRB assay Cytotoxicity against human MKN7 cells by SRB assay	[PMID: 24589486]
MKN-74	GI₅₀	3 nM Compound: 1, FK228	Growth inhibition of human MKN74 cells by sulforhodamine B colorimetric method Growth inhibition of human MKN74 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
MKN-74	GI₅₀	3 nM Compound: 1; FK228	Growth inhibition of human MKN-74 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MKN-74 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
MKN-74	GI₅₀	3 nM Compound: 5, FK228	Cytotoxicity against human MKN74 cells by SRB assay Cytotoxicity against human MKN74 cells by SRB assay	[PMID: 24589486]
MOLT-4	GI₅₀	2.06 nM Compound: 1, FK228	Antiproliferative activity against human MOLT4 cells after 72 hrs by CCK8 assay Antiproliferative activity against human MOLT4 cells after 72 hrs by CCK8 assay	[PMID: 26331334]
NCI-H226	GI₅₀	8.9 nM Compound: 1, FK228	Growth inhibition of human NCI-H226 cells by sulforhodamine B colorimetric method Growth inhibition of human NCI-H226 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
NCI-H226	GI₅₀	8.9 nM Compound: 1; FK228	Growth inhibition of human NCI-H226 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H226 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
NCI-H226	GI₅₀	8.9 nM Compound: 5, FK228	Cytotoxicity against human NCI-H226 cells by SRB assay Cytotoxicity against human NCI-H226 cells by SRB assay	[PMID: 24589486]
NCI-H23	GI₅₀	4.6 nM Compound: 1, FK228	Growth inhibition of human NCI-H23 cells by sulforhodamine B colorimetric method Growth inhibition of human NCI-H23 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
NCI-H23	GI₅₀	4.6 nM Compound: 1; FK228	Growth inhibition of human NCI-H23 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H23 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
NCI-H23	GI₅₀	4.6 nM Compound: 5, FK228	Cytotoxicity against human NCI-H23 cells by SRB assay Cytotoxicity against human NCI-H23 cells by SRB assay	[PMID: 24589486]
NCI-H460	GI₅₀	3 nM Compound: 1, FK228	Growth inhibition of human NCI-H460 cells by sulforhodamine B colorimetric method Growth inhibition of human NCI-H460 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
NCI-H460	GI₅₀	3 nM Compound: 1; FK228	Growth inhibition of human NCI-H460 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H460 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
NCI-H460	GI₅₀	3 nM Compound: 5, FK228	Cytotoxicity against human NCI-H460 cells by SRB assay Cytotoxicity against human NCI-H460 cells by SRB assay	[PMID: 24589486]
NCI-H522	GI₅₀	1.8 nM Compound: 1, FK228	Growth inhibition of human NCI-H522 cells by sulforhodamine B colorimetric method Growth inhibition of human NCI-H522 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
NCI-H522	GI₅₀	1.8 nM Compound: 1; FK228	Growth inhibition of human NCI-H522 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H522 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
NCI-H522	GI₅₀	1.8 nM Compound: 2; FK228	Cytotoxicity against human NCI-H522 cells assessed as cell growth inhibition by sulforhodamine B colorimetric method Cytotoxicity against human NCI-H522 cells assessed as cell growth inhibition by sulforhodamine B colorimetric method	[PMID: 34826681]
NCI-H522	GI₅₀	1.8 nM Compound: 5, FK228	Cytotoxicity against human NCI-H522 cells by SRB assay Cytotoxicity against human NCI-H522 cells by SRB assay	[PMID: 24589486]
NFF	IC₅₀	0.001 μM Compound: Romidepsin	Cytotoxicity against human NFF cells incubated for 72 hrs by SRB assay Cytotoxicity against human NFF cells incubated for 72 hrs by SRB assay	[PMID: 39208744]
NFF	IC₅₀	<= 0.001 μM Compound: 11; FK228	Cytotoxicity against human NFF cells after 72 hrs by SRB assay Cytotoxicity against human NFF cells after 72 hrs by SRB assay	[PMID: 28241112]
NFF	IC₅₀	<= 1 nM Compound: Romidepsin	Cytotoxicity against human NFF cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human NFF cells after 72 hrs by sulforhodamine B assay	[PMID: 30245402]
OVCAR-3	GI₅₀	4.6 nM Compound: 1, FK228	Growth inhibition of human OVCAR3 cells by sulforhodamine B colorimetric method Growth inhibition of human OVCAR3 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
OVCAR-3	GI₅₀	4.6 nM Compound: 1; FK228	Growth inhibition of human OVCAR-3 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR-3 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
OVCAR-3	GI₅₀	4.6 nM Compound: 5, FK228	Cytotoxicity against human OVCAR3 cells by SRB assay Cytotoxicity against human OVCAR3 cells by SRB assay	[PMID: 24589486]
OVCAR-4	GI₅₀	20 nM Compound: 1, FK228	Growth inhibition of human OVCAR4 cells by sulforhodamine B colorimetric method Growth inhibition of human OVCAR4 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
OVCAR-4	GI₅₀	20 nM Compound: 1; FK228	Growth inhibition of human OVCAR-4 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR-4 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
OVCAR-4	GI₅₀	20 nM Compound: 5, FK228	Cytotoxicity against human OVCAR4 cells by SRB assay Cytotoxicity against human OVCAR4 cells by SRB assay	[PMID: 24589486]
OVCAR-5	GI₅₀	2.8 nM Compound: 1, FK228	Growth inhibition of human OVCAR5 cells by sulforhodamine B colorimetric method Growth inhibition of human OVCAR5 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
OVCAR-5	GI₅₀	2.8 nM Compound: 1; FK228	Growth inhibition of human OVCAR-5 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR-5 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
OVCAR-5	GI₅₀	2.8 nM Compound: 5, FK228	Cytotoxicity against human OVCAR5 cells by SRB assay Cytotoxicity against human OVCAR5 cells by SRB assay	[PMID: 24589486]
OVCAR-8	GI₅₀	5.5 nM Compound: 1, FK228	Growth inhibition of human OVCAR8 cells by sulforhodamine B colorimetric method Growth inhibition of human OVCAR8 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
OVCAR-8	GI₅₀	5.5 nM Compound: 1; FK228	Growth inhibition of human OVCAR-8 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR-8 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
OVCAR-8	GI₅₀	5.5 nM Compound: 5, FK228	Cytotoxicity against human OVCAR8 cells by SRB assay Cytotoxicity against human OVCAR8 cells by SRB assay	[PMID: 24589486]
PC-3	GI₅₀	18 nM Compound: 1, FK228	Growth inhibition of human PC3 cells by sulforhodamine B colorimetric method Growth inhibition of human PC3 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
PC-3	GI₅₀	18 nM Compound: 1; FK228	Growth inhibition of human PC-3 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human PC-3 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
PC-3	GI₅₀	18 nM Compound: 5, FK228	Cytotoxicity against human PC3 cells by SRB assay Cytotoxicity against human PC3 cells by SRB assay	[PMID: 24589486]
RXF 631	GI₅₀	6.6 nM Compound: 1, FK228	Growth inhibition of human RXF631L cells by sulforhodamine B colorimetric method Growth inhibition of human RXF631L cells by sulforhodamine B colorimetric method	[PMID: 23313638]
RXF 631	GI₅₀	6.6 nM Compound: 1; FK228	Growth inhibition of human RXF 631 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human RXF 631 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
RXF 631	GI₅₀	6.6 nM Compound: 5, FK228	Cytotoxicity against human RXF631L cells by SRB assay Cytotoxicity against human RXF631L cells by SRB assay	[PMID: 24589486]
SF-268	GI₅₀	4.9 nM Compound: 1, FK228	Growth inhibition of human SF268 cells by sulforhodamine B colorimetric method Growth inhibition of human SF268 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
SF-268	GI₅₀	4.9 nM Compound: 1; FK228	Growth inhibition of human SF-268 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SF-268 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
SF-268	GI₅₀	4.9 nM Compound: 5, FK228	Cytotoxicity against human SF268 cells by SRB assay Cytotoxicity against human SF268 cells by SRB assay	[PMID: 24589486]
SF-295	GI₅₀	4 nM Compound: 1, FK228	Growth inhibition of human SF295 cells by sulforhodamine B colorimetric method Growth inhibition of human SF295 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
SF-295	GI₅₀	4 nM Compound: 1; FK228	Growth inhibition of human SF-295 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SF-295 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
SF-295	GI₅₀	4 nM Compound: 5, FK228	Cytotoxicity against human SF295 cells by SRB assay Cytotoxicity against human SF295 cells by SRB assay	[PMID: 24589486]
SF-539	GI₅₀	3.6 nM Compound: 1, FK228	Growth inhibition of human SF539 cells by sulforhodamine B colorimetric method Growth inhibition of human SF539 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
SF-539	GI₅₀	3.6 nM Compound: 1; FK228	Growth inhibition of human SF-539 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SF-539 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
SF-539	GI₅₀	3.6 nM Compound: 5, FK228	Cytotoxicity against human SF539 cells by SRB assay Cytotoxicity against human SF539 cells by SRB assay	[PMID: 24589486]
SK-OV-3	GI₅₀	3.3 nM Compound: 1, FK228	Growth inhibition of human SKOV3 cells by sulforhodamine B colorimetric method Growth inhibition of human SKOV3 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
SK-OV-3	GI₅₀	3.3 nM Compound: 1; FK228	Growth inhibition of human SK-OV-3 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SK-OV-3 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
SK-OV-3	GI₅₀	3.3 nM Compound: 5, FK228	Cytotoxicity against human SKOV3 cells by SRB assay Cytotoxicity against human SKOV3 cells by SRB assay	[PMID: 24589486]
SNB-75	GI₅₀	7.2 nM Compound: 1, FK228	Growth inhibition of human SNB75 cells by sulforhodamine B colorimetric method Growth inhibition of human SNB75 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
SNB-75	GI₅₀	7.2 nM Compound: 1; FK228	Growth inhibition of human SNB-75 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SNB-75 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
SNB-75	GI₅₀	7.2 nM Compound: 5, FK228	Cytotoxicity against human SNB75 cells by SRB assay Cytotoxicity against human SNB75 cells by SRB assay	[PMID: 24589486]
SNB-78	GI₅₀	9.6 nM Compound: 1, FK228	Growth inhibition of human SNB78 cells by sulforhodamine B colorimetric method Growth inhibition of human SNB78 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
SNB-78	GI₅₀	9.6 nM Compound: 1; FK228	Growth inhibition of human SNB-78 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SNB-78 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
SNB-78	GI₅₀	9.6 nM Compound: 5, FK228	Cytotoxicity against human SNB78 cells by SRB assay Cytotoxicity against human SNB78 cells by SRB assay	[PMID: 24589486]
Sf9	IC₅₀	0.0024 μM Compound: FK228	Inhibition of human recombinant C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells after 1 hr by HDAC-Glo1/2 luminescent assay Inhibition of human recombinant C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells after 1 hr by HDAC-Glo1/2 luminescent assay	[PMID: 31057733]
Sf9	IC₅₀	0.0091 μM Compound: FK228	Inhibition of human recombinant C-terminal FLAG-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells after 1 hr by HDAC-Glo1/2 luminescent assay Inhibition of human recombinant C-terminal FLAG-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells after 1 hr by HDAC-Glo1/2 luminescent assay	[PMID: 31057733]
Sf9	IC₅₀	4.462 μM Compound: FK228	Inhibition of human recombinant C-terminal GST-tagged HDAC4 (101 to 1084 residues) expressed in baculovirus infected Sf9 insect cells after 1 hr by HDAC-Glo1/2 luminescent assay Inhibition of human recombinant C-terminal GST-tagged HDAC4 (101 to 1084 residues) expressed in baculovirus infected Sf9 insect cells after 1 hr by HDAC-Glo1/2 luminescent assay	[PMID: 31057733]
St-4	GI₅₀	22 nM Compound: 1, FK228	Growth inhibition of human St-4 cells by sulforhodamine B colorimetric method Growth inhibition of human St-4 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
St-4	GI₅₀	22 nM Compound: 1; FK228	Growth inhibition of human St-4 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human St-4 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
St-4	GI₅₀	22 nM Compound: 5, FK228	Cytotoxicity against human St-4 cells by SRB assay Cytotoxicity against human St-4 cells by SRB assay	[PMID: 24589486]
T-cell	EC₅₀	0.003 μM Compound: Romidepsin, istodax	Reactivation of latent HIV1 NL4-3-Luc expression in human naive CD4+ T cells treated 7 days post-infection measured after 48 hrs by luminescence plate reader analysis Reactivation of latent HIV1 NL4-3-Luc expression in human naive CD4+ T cells treated 7 days post-infection measured after 48 hrs by luminescence plate reader analysis	[PMID: 24495105]
U-251	GI₅₀	3.9 nM Compound: 1, FK228	Growth inhibition of human U251 cells by sulforhodamine B colorimetric method Growth inhibition of human U251 cells by sulforhodamine B colorimetric method	[PMID: 23313638]
U-251	GI₅₀	3.9 nM Compound: 1; FK228	Growth inhibition of human U-251 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human U-251 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27318982]
U-251	GI₅₀	3.9 nM Compound: 5, FK228	Cytotoxicity against human U251 cells by SRB assay Cytotoxicity against human U251 cells by SRB assay	[PMID: 24589486]
U-937	CC₅₀	0.73 nM Compound: Romidepsin	Cytotoxicity against human U937 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human U937 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 29541372]
U-937	GI₅₀	3.41 nM Compound: 1, FK228	Antiproliferative activity against human U937 cells after 72 hrs by CCK8 assay Antiproliferative activity against human U937 cells after 72 hrs by CCK8 assay	[PMID: 26331334]
WI-38	GI₅₀	30.1 nM Compound: 2	Cytotoxicity against human WI-38 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay Cytotoxicity against human WI-38 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay	[PMID: 33745280]
WI-38	GI₅₀	5.39 nM Compound: 1, FK228	Antiproliferative activity against human WI38 cells after 72 hrs by CCK8 assay Antiproliferative activity against human WI38 cells after 72 hrs by CCK8 assay	[PMID: 26331334]

体外実験

Romidepsin (0-72 hours; 0-80 nM) inhibits proliferation of HCC cells in dose-dependent manner^[2].
Romidepsin (0-48 hours; 0-60 nM) leads to a time- and dose-dependent induction of cell cycle arrest in the G2/M phase in HCC cells^[2].
Romidepsin (0-48 hours; 0-60 nM) promotesapoptosis in HCC cells, increases c-caspase-3, c-caspase-9, and c-PARP protein expression^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:	HCC cells
Concentration:	0 nM; 10 nM; 20 nM; 30 nM; 40 nM; 50 nM; 60 nM; 70 nM; 80 nM
Incubation Time:	0 hours; 12 hours; 24 hours; 48 hours; 72 hours
Result:	Inhibited HCC cells proliferation.

Cell Cycle Analysis^[2]

Cell Line:	HCC cells
Concentration:	0 nM; 15 nM; 30 nM; 60 nM
Incubation Time:	12 hours;24 hours; 48 hours
Result:	Caused a G2/M arrest.

Western Blot Analysis^[2]

Cell Line:	HCC cells
Concentration:	0 nM; 15 nM; 30 nM; 60 nM
Incubation Time:	12 hours;24 hours; 48 hours
Result:	Increaesd c-caspase-3, c-caspase-9, and c-PARP expression in HCC cells.

体内実験

Romidepsin (intraperitoneal injection; 0.5 and 1 mg/kg; every 3 day; 21 days) inhibited the tumor growth, reveals a higher expression of p-cdc25C, ki67, c-caspase-3 and c-PARP, and a lower expression of Ki-67 in Romidepsin treated tumors ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Nude mice with Huh7 cells^[2]
Dosage:	0.5 and 1 mg/kg
Administration:	Intraperitoneal injection; 0.5 and 1 mg/kg; every 3 day; 21 days
Result:	Suppressed tumor growth in mouse xenograft models.

臨床実験

分子量

540.70

分子式

C₂₄H₃₆N₄O₆S₂

CAS 番号

128517-07-7

Appearance

Solid

Color

White to off-white

SMILES

C/C=C(NC([C@@H](CSSCC/C=C/[C@@H](O1)CC2=O)NC([C@@H](C(C)C)N2)=O)=O)/C(N[C@@H](C(C)C)C1=O)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
*The compound is unstable in solutions, freshly prepared is recommended.

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (184.95 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8495 mL	9.2473 mL	18.4945 mL
5 mM	0.3699 mL	1.8495 mL	3.6989 mL
10 mM	0.1849 mL	0.9247 mL	1.8495 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.08 mg/mL (3.85 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*The compound is unstable in solutions, freshly prepared is recommended.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.98%

Select Batch:

データシート (295 KB) SDS (396 KB)

COA (273 KB) HNMR (211 KB) LCMS (139 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Furumai R, et al. FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases. Cancer Res. 2002 Sep 1;62(17):4916-21. [Content Brief]

[2]. Sun WJ, et al. Romidepsin induces G2/M phase arrest via Erk/cdc25C/cdc2/cyclinB pathway and apoptosis induction through JNK/c-Jun/caspase3 pathway in hepatocellular carcinoma cells. Biochem Pharmacol. 2017 Mar 1;127:90-100. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8495 mL	9.2473 mL	18.4945 mL	46.2364 mL
	5 mM	0.3699 mL	1.8495 mL	3.6989 mL	9.2473 mL
	10 mM	0.1849 mL	0.9247 mL	1.8495 mL	4.6236 mL
	15 mM	0.1233 mL	0.6165 mL	1.2330 mL	3.0824 mL
	20 mM	0.0925 mL	0.4624 mL	0.9247 mL	2.3118 mL
	25 mM	0.0740 mL	0.3699 mL	0.7398 mL	1.8495 mL
	30 mM	0.0616 mL	0.3082 mL	0.6165 mL	1.5412 mL
	40 mM	0.0462 mL	0.2312 mL	0.4624 mL	1.1559 mL
	50 mM	0.0370 mL	0.1849 mL	0.3699 mL	0.9247 mL
	60 mM	0.0308 mL	0.1541 mL	0.3082 mL	0.7706 mL
	80 mM	0.0231 mL	0.1156 mL	0.2312 mL	0.5780 mL
	100 mM	0.0185 mL	0.0925 mL	0.1849 mL	0.4624 mL

Romidepsin Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Romidepsin128517-07-7FK 228 FR 901228 NSC 630176FK228FK-228FR901228FR 901228FR-901228NSC630176NSC 630176NSC-630176HDACApoptosisHistone deacetylasesInhibitorinhibitorinhibit

日本の代理先をお選びくださいナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
製品名			カスタマ需要量 *
お名前 *			タイトル
メールアドレス *			電話番号 *
デパートメント			組纖名 *
市区町村			都道府県
国或いは地域 *
必ず会社名を記載ください。個人への返信は行いません。
備考

製品名			Lot #
お名前 *			メールアドレス *
電話番号 *			部門 *
組纖名 *			国或いは地域 *
備考

ロミデプシン (Synonyms: Romidepsin; FK 228; FR 901228; NSC 630176)

カスタマーレビュー

Other Forms of Romidepsin:

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

HDAC アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Romidepsin Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

最近チェックした製品:

お名前
メール *

	Sorry, but the email address you supplied was invalid.

ロミデプシン (Synonyms: Romidepsin; FK 228; FR 901228; NSC 630176)

カスタマーレビュー

Other Forms of Romidepsin:

ロミデプシン 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

HDAC アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

ロミデプシン 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Romidepsin Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

最近チェックした製品:

カスタマーレビュー

Request for HNMR Report

Request for HNMR Report

ロミデプシン関連抗体

ロミデプシン関連抗体