2. Signaling Pathways
  3. Epigenetics
    TGF-beta/Smad
  4. PKC

PKC

Protein kinase C

PKC

Related Products

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PKC (Protein kinase C) is a family of protein kinase enzymes that are involved in controlling the function of otherproteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades. The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC is involved in receptor desensitization, in modulating membrane structure events, in regulating transcription, in mediating immune responses, in regulating cell growth, and in learning and memory. These functions are achieved by PKC-mediated phosphorylation of other proteins.

PKC Isoform Specific Products:

PKC Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-120515
    7-Oxostaurosporine
    		Inhibitor
    7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway.
    7-Oxostaurosporine
  • HY-12798CR
    AR-13503 (Standard)
    		Inhibitor
    Fluanisone (Standard) is the analytical standard of Fluanisone. This product is intended for research and analytical applications. Fluanisone has potent sedative effect in vivo. Fluanisone can be used to study schizophrenia.
    AR-13503 (Standard)
  • HY-P5884
    PKCθ pseudosubstrate peptide inhibitor,myristoylated
    		Inhibitor
    PKCθ pseudosubstrate peptide inhibitor, myristoylated is a synthetic peptide that can be used to study the mechanism of action of PKCθ.
    PKCθ pseudosubstrate peptide inhibitor,myristoylated
  • HY-155599
    HIV-1 protease-IN-10
    HIV-1 protease-IN-10 (Compound 2) has HIV-1 latency reversing activity (IC50: 0.22 μM). HIV-1 protease-IN-10 binds to the PKCδ C1b domain (IC50: 0.69 μM). HIV-1 protease-IN-10 has stability against esterase-mediated hydrolysis.
    HIV-1 protease-IN-10
  • HY-P5886
    PKC 20-28,myristoylated
    		Inhibitor
    PKC 20-28,myristoylated (Myristoylated protein kinase C inhibitor 20-28) is a cell-permeable PKC inhibitor that can be used in cancer research.
    PKC 20-28,myristoylated
  • HY-132304A
    (1S,4R)-CC-90005
    		Control 99.95%
    (1S,4R)-CC-90005 is the (1S,4R)-enantiomer of CC-90005 (HY-132304). CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50 = 4440 nM). CC-90005 can inhibit T cell activation by inhibiting IL-2 expression.
    (1S,4R)-CC-90005
  • HY-P2298A
    TAT-P4-(DATC5)2 TFA
    TAT-P4-(DATC5)2 TFA is a high-affinity peptide inhibitor of the PICK1 (protein interacting with C kinase-1) PDZ domain, with a Ki of 1.7 nM. TAT-P4-(DATC5)2 TFA can inhibit addiction in rats.
    TAT-P4-(DATC5)2 TFA
  • HY-P1597A
    Malantide TFA
    Malantide TFA is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide TFA is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts. Malantide TFA is also an efficient substrate for PKC with a Km of 16 μM.
    Malantide TFA
  • HY-12798E
    (R)-AR-13503
    		Control 98.20%
    (R)-AR-13503 ((R)-AR-13324 M1 metabolite) is the the (R)-enantiomer of AR-13503 (HY-12798C). AR-13503 is the hydrolytic metabolite of AR-13324 mesylate. AR-13324 is a ROCK kinase and PKC inhibitor with anti-angiogenic and retinal health-improving effects, showing potential for use in retinal disease research.
    (R)-AR-13503
  • HY-P1289A
    [Ala107]MBP(104-118)
    		Inhibitor
    [Ala107]MBP(104-118) is an noncompetitive peptide inhibitors of protein kinase C (PKC), with IC50s ranging from 46-145 μM.
    [Ala107]MBP(104-118)
  • HY-P1716
    Neuropeptide DF2
    		Activator
    Neuropeptide DF2 is a DRNFLRFamide neuropeptide orignally isolated from crayfish. which enhances transmitter release and stimulates the amplitude of excitatory post-synaptic potentials (EPSP) through the calcium/calmodulin-dependent protein kinase.
    Neuropeptide DF2
  • HY-163362
    HIV-1 inhibitor-65
    		Inhibitor
    HIV-1 inhibitor-65 (compound 3c) is an inhibitor of HIV-1 (EC50: 2.9 nM) and an activator of protein kinase C (PKC). HIV-1 inhibitor-65 inhibits syncytium formation (EC50: 7.0 nM) and inhibits HIV-1 entry and HIV-1 reverse transcriptase.
    HIV-1 inhibitor-65
  • HY-18981S
    Decursin-d6
    Decursin-d6 ((+)-Decursin-d6) is the deuterium labeled Decursin (HY-18981). Decursin ((+)-Decursin) is a potent anti-tumor agent. Decursin also is a cytotoxic agent and a potent protein kinase C activator. Decursin induces apoptosis and cell cycle arrest at G1 phase. Decursin decreases the expression of CDK2, CDK4, CDK6, cyclin D1 protein at 48 h. Decursin inhibits cell proliferation and migration. Decursin shows anti-tumor, anti-inflammatory and analgesic activities.
    Decursin-d<sub>6</sub>
  • HY-E70854
    PKCε Recombinant Human Active Protein Kinase
    PKCε is an isoform of the large PKC family of protein kinases. In cardiac muscle cells, PKCε regulates muscle contraction through its actions at sarcomeric proteins, and PKCε modulates cardiac cell metabolism through its actions at mitochondria. PKCε Recombinant Human Active Protein Kinase is a recombinant PKCε protein that can be used to study PKCε-related functions.
    PKCε Recombinant Human Active Protein Kinase
  • HY-B1029R
    Danazol (Standard)
    		Modulator
    Danazol standard inhibits the proliferation of cancer cell MDA-MB-231 and MCF-7 with IC50 of 65 µg/mL and 31 µg/mL. Danazol arrests the cell cycle at G1 phase, induces apoptosis in MDA-MB-231 through PKCα signaling pathway.
    Danazol (Standard)
  • HY-10540
    Sotrastaurin acetate
    		Inhibitor
    Sotrastaurin (AEB071) acetate is a selective, orally active PKC inhibitor. Sotrastaurin acetate inactivates NF-κB by inhibiting PKC α, β, θ, γ subtypes, thereby reducing the transcription levels of immune response-related genes. Sotrastaurin acetate effectively inhibits alloreactive T cell proliferation, conventional T cell activation, as well as the production of pro-inflammatory cytokines and B lymphocytes. Sotrastaurin acetate also maintains the functional and phenotypic stability of regulatory T cells, enhances Foxp3 expression and restores the balance of helper T lymphocytes. Sotrastaurin acetate can prolong the survival time of allografts, and alleviate inflammatory responses and myasthenic symptoms by reducing anti-AChR antibody levels. Sotrastaurin acetate is widely used in studies related to kidney transplantation, psoriasis and myasthenia gravis.
    Sotrastaurin acetate
  • HY-P3838
    Protein Kinase C γ Peptide
    Protein Kinase C (gamma) Peptide is a peptide fragment of Protein Kinase Cγ. Protein Kinase Cγ is a protein causative for dominant ataxia, that can negatively regulate nuclear import of recessive-ataxia-related aprataxin.
    Protein Kinase C γ Peptide
  • HY-RS11119
    PRKCB Human Pre-designed siRNA Set A
    		Inhibitor

    PRKCB Human Pre-designed siRNA Set A contains three designed siRNAs for PRKCB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    PRKCB Human Pre-designed siRNA Set A
  • HY-136490S1
    Psychosine-d7
    		99%
    Psychosine-d7 is deuterium labeled Psychosine. Psychosine, a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell
    Psychosine-d<sub>7</sub>
  • HY-RS11138
    Prkcq Mouse Pre-designed siRNA Set A
    		Inhibitor

    Prkcq Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkcq gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkcq Mouse Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Application Reactivity
PKC Isoform Comparison

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