1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
    Epigenetics
    TGF-beta/Smad
  2. PKA
    PKC
  3. Malantide TFA

Malantide TFA 

Cat. No.: HY-P1597A
Handling Instructions

Malantide TFA is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide TFA is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts. Malantide TFA is also an efficient substrate for PKC with a Km of 16 μM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Malantide TFA Chemical Structure

Malantide TFA Chemical Structure

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Description

Malantide TFA is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide TFA is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts[1]. Malantide TFA is also an efficient substrate for PKC with a Km of 16 μM[2].

IC50 & Target

Km: 15 μM (PKA)[1], 16 μM (PKC)[2], 233 μM (PKG)[1]

In Vitro

The Km values of Malantide are 15 μM and 223 μM for PKA and PKG, respectively. The Vmax values are 23.8 units/mg and 6.6 units/mg for for PKA and PKG, respectively[1].
A statistically significant effect of isoprenaline on the activity ratio of guinea-pig heart was only: observed with Malantide[1].

Molecular Weight

1747.91

Formula

C₇₄H₁₂₅F₃N₂₂O₂₃

Sequence

Arg-Thr-Lys-Arg-Ser-Gly-Ser-Val-Tyr-Glu-Pro-Leu-Lys-Ile

Sequence Shortening

RTKRSGSVYEPLKI

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

MalantidePKAPKCProtein kinase AProtein kinase CcAMPphosphorylateddodecapeptideβ-subunitsubstratehistoneInhibitorinhibitorinhibit

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Malantide TFA
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HY-P1597A
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