2. Stem Cell/Wnt TGF-beta/Smad Epigenetics
  3. PKA PKC
  4. Malantide

Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts. Malantide is also an efficient substrate for PKC with a Km of 16 μM.

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Custom Peptide Synthesis

Malantide Chemical Structure

Malantide Chemical Structure

CAS No. : 86555-35-3

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5 mg USD 180 In-stock
10 mg USD 280 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Malantide:

Malantide Related Antibodies

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

  • Biological Activity

  • Purity & Documentation

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Description

Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts[1]. Malantide is also an efficient substrate for PKC with a Km of 16 μM[2].

IC50 & Target

Km: 15 μM (PKA)[1], 16 μM (PKC)[2], 233 μM (PKG)[1]
In Vitro

The Km values of Malantide are 15 μM and 223 μM for PKA and PKG, respectively. The Vmax values are 23.8 units/mg and 6.6 units/mg for for PKA and PKG, respectively[1].
A statistically significant effect of isoprenaline on the activity ratio of guinea-pig heart was only: observed with Malantide[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Malantide Related Antibodies
Molecular Weight

1633.89

Formula

C72H124N22O21
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Arg-Thr-Lys-Arg-Ser-Gly-Ser-Val-Tyr-Glu-Pro-Leu-Lys-Ile
Sequence Shortening

RTKRSGSVYEPLKI
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (61.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6120 mL 3.0602 mL 6.1204 mL
5 mM 0.1224 mL 0.6120 mL 1.2241 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6120 mL 3.0602 mL 6.1204 mL 15.3009 mL
5 mM 0.1224 mL 0.6120 mL 1.2241 mL 3.0602 mL
10 mM 0.0612 mL 0.3060 mL 0.6120 mL 1.5301 mL
15 mM 0.0408 mL 0.2040 mL 0.4080 mL 1.0201 mL
20 mM 0.0306 mL 0.1530 mL 0.3060 mL 0.7650 mL
25 mM 0.0245 mL 0.1224 mL 0.2448 mL 0.6120 mL
30 mM 0.0204 mL 0.1020 mL 0.2040 mL 0.5100 mL
40 mM 0.0153 mL 0.0765 mL 0.1530 mL 0.3825 mL
50 mM 0.0122 mL 0.0612 mL 0.1224 mL 0.3060 mL
60 mM 0.0102 mL 0.0510 mL 0.1020 mL 0.2550 mL
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Malantide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Malantide86555-35-3PKAPKCProtein kinase AProtein kinase CcAMPphosphorylateddodecapeptideβ-subunitsubstratehistoneInhibitorinhibitorinhibit

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