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  2. TAT-P4-(DATC5)2 TFA

TAT-P4-(DATC5)2 TFA 

Cat. No.: HY-P2298A
Handling Instructions

TAT-P4-(DATC5)2 TFA is a high-affinity peptide inhibitor of the PICK1 (protein interacting with C kinase-1) PDZ domain, with a Ki of 1.7 nM. TAT-P4-(DATC5)2 TFA attenuats the reinstatement of cocaine seeking in rats.

For research use only. We do not sell to patients.

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TAT-P4-(DATC5)2 TFA Chemical Structure

TAT-P4-(DATC5)2 TFA Chemical Structure

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Description

TAT-P4-(DATC5)2 TFA is a high-affinity peptide inhibitor of the PICK1 (protein interacting with C kinase-1) PDZ domain, with a Ki of 1.7 nM. TAT-P4-(DATC5)2 TFA attenuats the reinstatement of cocaine seeking in rats[1].

IC50 & Target

Ki: 1.7 nM (PICK1 PDZ domain)[1]

In Vivo

TAT-P4-(DATC5)2 TFA (0.99 μg/kg, 9.9 μg/kg; Infused intravenously) dose-dependently attenuats the reinstatement of cocaine seeking in rats at doses that do not produce operant learning deficits or suppress locomotor activity [1].

Animal Model: Male Sprague-Dawley rats (250-300 g) [1]
Dosage: 0.99 μg/kg, 9.9 μg/kg
Administration: Infused intravenously, 45 min prior to an acute injection of cocaine (10 mg/kg, i.p.)
Result: Attenuated the reinstatement of cocaine seeking in rats.
Molecular Weight

3403.97

Formula

C₁₅₂H₂₄₇F₃N₅₂O₃₄

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TAT-P4-(DATC5)2OthersPICK1proteininteractingwithCkinase-1PDZdomaincocaineInhibitorinhibitorinhibit

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TAT-P4-(DATC5)2 TFA
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HY-P2298A
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