1. Anti-infection
  2. Bacterial Antibiotic
  3. Tosufloxacin tosylate hydrate

Tosufloxacin tosylate hydrate  (Synonyms: A-61827 tosylate hydrate; T-3262)

Cat. No.: HY-B1802A Purity: 99.03%
COA Handling Instructions

Tosufloxacin tosylate hydrate (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria.

For research use only. We do not sell to patients.

Tosufloxacin tosylate hydrate Chemical Structure

Tosufloxacin tosylate hydrate Chemical Structure

CAS No. : 1400591-39-0

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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1 g USD 108 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Tosufloxacin tosylate hydrate:

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Description

Tosufloxacin tosylate hydrate (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria[1][2].

IC50 & Target

Quinolone

 

In Vitro

Tosufloxacin tosylate hydrate (T-3262) (0.05-3.13 μg/mL; 18 h) shows antibacterial activities against S. aureus, Staphylococcus epidermidis, streptococci, enterococci, Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: S. aureus, Staphylococcus epidermidis, streptococci, enterococci, Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens
Concentration: 0.05-3.13 μg/mL
Incubation Time: 18 hours
Result: Showed MIC90s (MICs for 90% of the isolates tested) ranging from 0.05 to 1.56 μg/mL for S. aureus, Staphylococcus epidermidis, streptococci, and enterococci.
Showed MIC90s of 1.56, 3.13, and 0.20 μg/mL for Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens, respectively.
In Vivo

Tosufloxacin tosylate hydrate (T-3262) (oral gavage; 0.16-13.39 mg/kg; once) treatment shows antibacterial activity against S. aureus, E. coli, and P. aeruginosa in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Slc:ICR mice infected with S. aureus[2]
Dosage: 1.27-2.15 mg/kg
Administration: Oral gavage; 1.27-2.15 mg/kg; once
Result: Showed 50% effective dose (ED50) of 1.62 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.0125 μg/mL.
Animal Model: Male Slc:ICR mice infected with E. coli[2]
Dosage: 0.16-0.30 mg/kg
Administration: Oral gavage; 0.16-0.30 mg/kg; once
Result: Showed 50% effective dose (ED50) of 0.22 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.0125 μg/mL.
Animal Model: Male Slc:ICR mice infected with P. aeruginosa[2]
Dosage: 7.66-13.39 mg/kg
Administration: Oral gavage; 7.66-13.39 mg/kg; once
Result: Showed 50% effective dose (ED50) of 10.13 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.78 μg/mL.
Molecular Weight

594.56

Formula

C26H25F3N4O7S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=C(S(=O)(O)=O)C=C1.O=C(C2=CN(C3=CC=C(F)C=C3F)C4=C(C=C(F)C(N5CC(N)CC5)=N4)C2=O)O.O

Structure Classification
Initial Source

Salmonella enteritidis

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (21.02 mM; Need ultrasonic)

H2O : 1 mg/mL (1.68 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6819 mL 8.4096 mL 16.8192 mL
5 mM 0.3364 mL 1.6819 mL 3.3638 mL
10 mM 0.1682 mL 0.8410 mL 1.6819 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 1.25 mg/mL (2.10 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1.25 mg/mL (2.10 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 1.25 mg/mL (2.10 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Tosufloxacin tosylate hydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Tosufloxacin tosylate hydrate
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