2. Anti-infection
  3. Antibiotic Bacterial
  4. Tosufloxacin tosylate

Tosufloxacin tosylate  (Synonyms: A-61827 tosylate)

Cat. No.: HY-B1802C
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Tosufloxacin (A-61827) tosylate is an orally active fluoroquinolone antibiotic. Tosufloxacin tosylate shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria.

For research use only. We do not sell to patients.

Tosufloxacin tosylate Chemical Structure

Tosufloxacin tosylate Chemical Structure

CAS No. : 115964-29-9

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Description

Tosufloxacin (A-61827) tosylate is an orally active fluoroquinolone antibiotic. Tosufloxacin tosylate shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria[1][2].

In Vitro

Tosufloxacin tosylate hydrate (T-3262) (0.05-3.13 μg/mL; 18 h) shows antibacterial activities against S. aureus, Staphylococcus epidermidis, streptococci, enterococci, Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tosufloxacin tosylate Related Antibodies

Cell Viability Assay[2]

Cell Line: S. aureus, Staphylococcus epidermidis, streptococci, enterococci, Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens
Concentration: 0.05-3.13 μg/mL
Incubation Time: 18 hours
Result: Showed MIC90s (MICs for 90% of the isolates tested) ranging from 0.05 to 1.56 μg/mL for S. aureus, Staphylococcus epidermidis, streptococci, and enterococci.
Showed MIC90s of 1.56, 3.13, and 0.20 μg/mL for Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens, respectively.
In Vivo

Tosufloxacin tosylate hydrate (T-3262) (oral gavage; 0.16-13.39 mg/kg; once) treatment shows antibacterial activity against S. aureus, E. coli, and P. aeruginosa in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Slc:ICR mice infected with S. aureus[2]
Dosage: 1.27-2.15 mg/kg
Administration: Oral gavage; 1.27-2.15 mg/kg; once
Result: Showed 50% effective dose (ED50) of 1.62 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.0125 μg/mL.
Animal Model: Male Slc:ICR mice infected with E. coli[2]
Dosage: 0.16-0.30 mg/kg
Administration: Oral gavage; 0.16-0.30 mg/kg; once
Result: Showed 50% effective dose (ED50) of 0.22 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.0125 μg/mL.
Animal Model: Male Slc:ICR mice infected with P. aeruginosa[2]
Dosage: 7.66-13.39 mg/kg
Administration: Oral gavage; 7.66-13.39 mg/kg; once
Result: Showed 50% effective dose (ED50) of 10.13 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.78 μg/mL.
Molecular Weight

576.54

Formula

C26H23F3N4O6S
CAS No.
SMILES

O=C(O)C1=CN(C2=NC(N3CC(CC3)N)=C(C=C2C1=O)F)C4=CC=C(C=C4F)F.OS(=O)(C5=CC=C(C=C5)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Tosufloxacin tosylate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tosufloxacin115964-29-9A-61827A61827A 61827AntibioticBacterialantibacterial activitygram-positive bacteriagram-negative bacteriaS. aureusStaphylococcus epidermidisstreptococcienterococciBacteroides fragilisClostridium difficileClostridium perfringensInhibitorinhibitorinhibit

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