Neamine tetrahydrochloride
Based on 1 Customer Validation
Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities.
For research use only. We do not sell to patients.
- Purity: 99.92%
- CAS No.: 15446-43-2
- Formula: C12H30Cl4N4O6
- Molecular Weight:468.20
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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Aminoglycoside |
Neamine (0.625-25 μM; 48 hours; AsPC-1 cells) treatment inhibits ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in the range of 0.625-25 μM[1].
Neamine (100 μM) also blocks the nuclear translocation of ANG effectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:AsPC-1 cells
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Concentration:0.625 µM, 1.25 µM, 2.5 µM, 5 µM, 10 µM, 25 µM
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Incubation Time:48 hours
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Result:Inhibited angiogenin (ANG)-induced AsPC-1 cells proliferation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells[1]
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Dosage:30 mg/kg, 60 mg/kg
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Administration:Subcutaneous injection; daily; for 14 days
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Result:Had anti-tumor effects on AsPC-1 xenograft models.
Chemical Information
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CAS No. 15446-43-2
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Appearance Solid
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Molecular Weight 468.20
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Formula C12H30Cl4N4O6
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Color White to off-white
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SMILES
O[C@H]([C@H]([C@@H](C[C@@H]1N)N)O)[C@@H]1O[C@H]2O[C@@H]([C@H]([C@@H]([C@H]2N)O)O)CN.Cl.Cl.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Ya-Ping Liu, et al. Neamine Inhibits Growth of Pancreatic Cancer Cells in Vitro and in Vivo. J Huazhong Univ Sci Technolog Med Sci. 2016 Feb;36(1):82-87. [Content Brief]
[2]. R Ning, et al. Neamine Induces Neuroprotection After Acute Ischemic Stroke in Type One Diabetic Rats. Neuroscience. 2014 Jan 17;257:76-85. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Neamine tetrahydrochloride Related Classifications
HY-115349 Related Classifications
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