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Cat. No.: HY-17466A

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Sancycline hydrochloride

(Synonyms: Bonomycin hydrochloride; 6-Demethyl-6-deoxytetracycline hydrochloride)

Sancycline (6-Demethyl-6-deoxytetracycline) hydrochloride acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline hydrochloride, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin.

For research use only. We do not sell to patients.

CAS No.: 6625-20-3
Formula: C₂₁H₂₃ClN₂O₇
Molecular Weight:450.87

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Sancycline hydrochloride Chemical Structure

CAS No.: 6625-20-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Tetracycline

All Antibiotic Isoforms :

In Vitro

Sancycline hydrochloride (400 μM, 24 h) decreases 2 chloroethyl ethyl sulfide (CEES) and nitrogen mustard (NM) induced corneal injuries and inhibits Matrix metalloproteinase (MMP)-9 expression to some degree in the basement membrane zone (BMZ) increased by NM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[2]

Cell Line:

Frozen corneal sections
Concentration:

400 μM
Incubation Time:

24 h
Result:

lnhibited MMP-9 expression to some degree in the NM-exposed corneas.

Chemical Information

CAS No. 6625-20-3
Appearance Solid
Molecular Weight 450.87
Formula C₂₁H₂₃ClN₂O₇
Color White to off-white
SMILES

O=C(N)C1=C([C@H]([C@@]([H])([C@]2(C1=O)O)C[C@]3(C(C(C4=C(C=CC=C4C3)O)=O)=C2O)[H])N(C)C)O.Cl
Synonyms

Bonomycin hydrochloride; 6-Demethyl-6-deoxytetracycline hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li G, et al. A brief overview of classical natural product drug synthesis and bioactivity[J]. Organic Chemistry Frontiers, 2022, 9(2): 517-571.

[2]. Gordon MK, et al. Doxycycline hydrogels as a potential therapy for ocular vesicant injury[J]. J Ocul Pharmacol Ther. 2010 Oct;26(5):407-19. [Content Brief]

[3]. Nikita Shanmugam, et al. Abraham solvation parameter model: determination of experiment-based solute descriptor values for 3,5-dimethoxybenzoic acid based on measured solubility data[J]. Physics and Chemistry of Liquids. 2024. 62: 2: 89-100.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Sancycline hydrochloride

High-Throughput Bioactive Compound Library

All Antibiotic Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Sancycline hydrochloride Related Classifications

HY-17466A Related Classifications