6625-20-3
Chemical Structure
Sancycline hydrochloride
Synonym(s): Bonomycin hydrochloride; 6-Demethyl-6-deoxytetracycline hydrochloride
- CAS No.: 6625-20-3
- Formula:C21H23ClN2O7
- Molecular Weight:450.87
IUPAC Name: (4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
InChIKey: NHHHLWBNBLFCSB-QKYUADJBSA-N
SMILES: O=C(N)C1=C([C@H]([C@@]([H])([C@]2(C1=O)O)C[C@]3(C(C(C4=C(C=CC=C4C3)O)=O)=C2O)[H])N(C)C)O.Cl
Biological Activity: Sancycline (6-Demethyl-6-deoxytetracycline) hydrochloride acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline hydrochloride, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin[1][2][3].
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Sancycline hydrochloride | Sancycline (6-Demethyl-6-deoxytetracycline) hydrochloride acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline hydrochloride, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin. | |||||||||||||||||||||
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References
- [1]. Li G, et al. A brief overview of classical natural product drug synthesis and bioactivity[J]. Organic Chemistry Frontiers, 2022, 9(2): 517-571.
- [2]. Gordon MK, et al. Doxycycline hydrogels as a potential therapy for ocular vesicant injury[J]. J Ocul Pharmacol Ther. 2010 Oct;26(5):407-19. [Content Brief]
- [3]. Nikita Shanmugam, et al. Abraham solvation parameter model: determination of experiment-based solute descriptor values for 3,5-dimethoxybenzoic acid based on measured solubility data[J]. Physics and Chemistry of Liquids. 2024. 62: 2: 89-100.
