Tosufloxacin hydrochloride
Tosufloxacin (A-61827) hydrochloride is an orally active fluoroquinolone antibiotic. Tosufloxacin hydrochloride shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria.
For research use only. We do not sell to patients.
- CAS No.: 104051-69-6
- Formula: C19H16ClF3N4O3
- Molecular Weight:440.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Antibiotic Isoforms
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Biological Activity
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Quinolone |
Tosufloxacin tosylate hydrate (T-3262) (0.05-3.13 μg/mL; 18 h) shows antibacterial activities against S. aureus, Staphylococcus epidermidis, streptococci, enterococci, Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:S. aureus, Staphylococcus epidermidis, streptococci, enterococci, Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens
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Concentration:0.05-3.13 μg/mL
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Incubation Time:18 hours
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Result:Showed MIC90s (MICs for 90% of the isolates tested) ranging from 0.05 to 1.56 μg/mL for S. aureus, Staphylococcus epidermidis, streptococci, and enterococci.
Showed MIC90s of 1.56, 3.13, and 0.20 μg/mL for Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Slc:ICR mice infected with S. aureus[2]
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Dosage:1.27-2.15 mg/kg
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Administration:Oral gavage; 1.27-2.15 mg/kg; once
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Result:Showed 50% effective dose (ED50) of 1.62 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.0125 μg/mL.
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Animal Model:Male Slc:ICR mice infected with E. coli[2]
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Dosage:0.16-0.30 mg/kg
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Administration:Oral gavage; 0.16-0.30 mg/kg; once
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Result:Showed 50% effective dose (ED50) of 0.22 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.0125 μg/mL.
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Animal Model:Male Slc:ICR mice infected with P. aeruginosa[2]
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Dosage:7.66-13.39 mg/kg
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Administration:Oral gavage; 7.66-13.39 mg/kg; once
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Result:Showed 50% effective dose (ED50) of 10.13 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.78 μg/mL.
Chemical Information
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CAS No. 104051-69-6
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Molecular Weight 440.80
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Formula C19H16ClF3N4O3
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SMILES
FC1=CC(F)=C(C=C1)N2C=C(C(C3=C2N=C(C(F)=C3)N4CCC(C4)N)=O)C(O)=O.Cl
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Synonyms
A-61827 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Chu DT, et al. Synthesis and biological properties of A-71497: a prodrug of tosufloxacin. Drugs Exp Clin Res. 1990;16(9):435-43. [Content Brief]
[2]. Fujimaki K, et al. In vitro and in vivo antibacterial activities of T-3262, a new fluoroquinolone. Antimicrob Agents Chemother. 1988 Jun;32(6):827-33. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tosufloxacin hydrochloride Related Classifications
HY-B1802B Related Classifications
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