2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. (RS)-MCPG

(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

(RS)-MCPG

(RS)-MCPG Chemical Structure

CAS No. : 146669-29-6

Size Prix Stock Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg En stock
200 mg   Obtenir un devis  
500 mg   Obtenir un devis  

* Veuillez sélectionner la quantité avant d'ajouter des articles.

This product is a controlled substance and not for sale in your territory.

Avis client

Based on 1 publication(s) in Google Scholar

Other Forms of (RS)-MCPG:

(RS)-MCPG Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE (RS)-MCPG

Voir tous les produits spécifiques à Isoform mGluR:

Voir toutes les isoformes
mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • Activité biologique

  • Pureté et documentation

  • Références

  • Avis client

Description

(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons[1][2].

IC50 & Target[1]

mGluR

 

Cellular Effect
Cell Line Type Value Description References
CHO IC50
700 3
Compound: 3b
Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells.
Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells.
10.1016/0960-894X(96)00104-7
CHO IC50
700 3
Compound: 3b
Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells.
Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells.
10.1016/0960-894X(96)00104-7
In Vitro

MCPG can block group I (mGluR1 and mGluR5) and group II receptors (mGluR2 and mGluR3)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(RS)-MCPG Related Antibodies
In Vivo

(RS)-MCPG (alpha-MCPG; 500 μM) blocks the TBS-induced shifts in EGABA in either juvenile or neonatal neurons[1].
Pretreatment with the low dose of (RS)-MCPG (25 nM; i.c.; daily; 5 days) significantly attenuates amphetamine-induced locomotor activity in 10-day-old male and female rats of Sprague-Dawley descent[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Masse moléculaire

209.20

Formule

C10H11NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C(O)=O)(N)C1=CC=C(C(O)=O)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvant et solubilité
In Vitro: 

1M NaOH : 100 mg/mL (478.01 mM; ultrasonic and adjust pH to 10 with NaOH)

DMSO : 6 mg/mL (28.68 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7801 mL 23.9006 mL 47.8011 mL
5 mM 0.9560 mL 4.7801 mL 9.5602 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureté et documentation
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / 1M NaOH 1 mM 4.7801 mL 23.9006 mL 47.8011 mL 119.5029 mL
5 mM 0.9560 mL 4.7801 mL 9.5602 mL 23.9006 mL
10 mM 0.4780 mL 2.3901 mL 4.7801 mL 11.9503 mL
15 mM 0.3187 mL 1.5934 mL 3.1867 mL 7.9669 mL
20 mM 0.2390 mL 1.1950 mL 2.3901 mL 5.9751 mL
25 mM 0.1912 mL 0.9560 mL 1.9120 mL 4.7801 mL
1M NaOH 30 mM 0.1593 mL 0.7967 mL 1.5934 mL 3.9834 mL
40 mM 0.1195 mL 0.5975 mL 1.1950 mL 2.9876 mL
50 mM 0.0956 mL 0.4780 mL 0.9560 mL 2.3901 mL
60 mM 0.0797 mL 0.3983 mL 0.7967 mL 1.9917 mL
80 mM 0.0598 mL 0.2988 mL 0.5975 mL 1.4938 mL
100 mM 0.0478 mL 0.2390 mL 0.4780 mL 1.1950 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

(RS)-MCPG Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(RS)-MCPG146669-29-6alpha-MCPGmGluRMetabotropic glutamate receptorsgroupI/IImetabotropicglutamatereceptorhippocampalneuronsmGluR1mGluR5mGluR2mGluR3Inhibitorinhibitorinhibit

Vos produits récemment consultés:

Demande en ligne

Your information is safe with us. * Required Fields.

Nom du produit

  

Requested Quantity *

Nom du demandeur *

 

Civilité

Adresse e-mail *

 

Numéro de téléphone *

Department

 

Nom de l'organisation *

City

État

Country or Region *

      

Remarques

Bulk Inquiry

Inquiry Information

Nom du produit:
(RS)-MCPG
Cat. No.:
HY-100371
Quantité:
MCE Japan Authorized Agent:

Avis client

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nom du produit

  

Lot #

Nom du demandeur *

 

Adresse e-mail *

Numéro de téléphone

 

Department *

Nom de l'organisation *

 

Country or Region *

Remarques

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.