(S)-β-Aminoisobutyric acid

Name: (S)-β-Aminoisobutyric acid
Brand: MedChemExpress
SKU: HY-113380
Rating: 4.5 (1 reviews)

Art. -Nr.: HY-113380 Reinheit: 99.59%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

(S)-β-Aminoisobutyric acid is an orally active S-isomer of β-Aminoisobutyric acid (HY-W012974). (S)-β-Aminoisobutyric acid can be produced through the catabolism of thymine and valine. (S)-β-Aminoisobutyric acid reduces apoptosis and increases the ratio of p-AMPK. (S)-β-Aminoisobutyric acid has cardioprotective effects. (S)-β-Aminoisobutyric acid is associated with acute aerobic exercise.

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(S)-β-Aminoisobutyric acid Chemische Struktur

CAS. Nr. : 4249-19-8

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
500 mg	Auf Lager	Estimated Time of Arrival: December 31
1 g	Auf Lager	Estimated Time of Arrival: December 31
5 g	Auf Lager	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of (S)-β-Aminoisobutyric acid:

3-Aminoisobutyric acid In-stock
(S)-β-Aminoisobutyric acid hydrochloride In-stock
(S)-β-Aminoisobutyric acid (Standard) Angebot einholen

1 Publications Citing Use of MCE (S)-β-Aminoisobutyric acid

•Front Cardiovasc Med. 2022 Feb 25;9:803510. [Abstract]

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Human Endogenous Metabolite Microbial Metabolite

Alle AMPK Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

(S)-β-Aminoisobutyric acid (10-30 mM) increases p-AMPK expression in a dose-dependent manner in H9C2 cardiomyocytes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(S)-β-Aminoisobutyric acid (75 mg/kg; p.o.; 8 weeks) improves the cardiac structure and function of rats with heart failure after myocardial infarction^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley rats with heart failure^[2]
Dosage:	75 mg/kg
Administration:	Oral gavage (p.o.); 8 weeks
Result:	Improved the left ventricular morphological abnormalities. Alleviated cardiomyocyte lysis and necrosis as well as reduced the numbers of disordered structures. Reduced collagen deposition, and increased the EF, FS and IVDs while decreased the LVIDd and LVIDs. Effectively reversed the morphological destruction of mitochondria. Reversed the decreases in ATP production.

Molekulargewicht

103.12

Formel

C₄H₉NO₂

CAS. Nr.

4249-19-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@H](C)CN

Structure Classification

Amino acids

Initial Source

Microorganisms

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 250 mg/mL (2424.36 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	9.6974 mL	48.4872 mL	96.9744 mL
5 mM	1.9395 mL	9.6974 mL	19.3949 mL
10 mM	0.9697 mL	4.8487 mL	9.6974 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (969.74 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Reinheit & Dokumentation

Purity: 99.59%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (245 KB) HNMR (230 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

Verweise

[1]. CRUMPLER HR, et al. beta-Aminoisobutyric acid (alpha-methyl-beta-alanine); a new amino-acid obtained from human urine. Nature. 1951 Feb 24;167(4243):307-8. [Content Brief]

[2]. Yu Y, et al. Exercise-Generated β-Aminoisobutyric Acid (BAIBA) Reduces Cardiomyocyte Metabolic Stress and Apoptosis Caused by Mitochondrial Dysfunction Through the miR-208b/AMPK Pathway. Front Cardiovasc Med. 2022 Feb 25;9:803510. [Content Brief]

[3]. Stautemas J, et al. Acute Aerobic Exercise Leads to Increased Plasma Levels of R- and S-β-Aminoisobutyric Acid in Humans. Front Physiol. 2019 Sep 25;10:1240. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	9.6974 mL	48.4872 mL	96.9744 mL	242.4360 mL
	5 mM	1.9395 mL	9.6974 mL	19.3949 mL	48.4872 mL
	10 mM	0.9697 mL	4.8487 mL	9.6974 mL	24.2436 mL
	15 mM	0.6465 mL	3.2325 mL	6.4650 mL	16.1624 mL
	20 mM	0.4849 mL	2.4244 mL	4.8487 mL	12.1218 mL
	25 mM	0.3879 mL	1.9395 mL	3.8790 mL	9.6974 mL
	30 mM	0.3232 mL	1.6162 mL	3.2325 mL	8.0812 mL
	40 mM	0.2424 mL	1.2122 mL	2.4244 mL	6.0609 mL
	50 mM	0.1939 mL	0.9697 mL	1.9395 mL	4.8487 mL
	60 mM	0.1616 mL	0.8081 mL	1.6162 mL	4.0406 mL
	80 mM	0.1212 mL	0.6061 mL	1.2122 mL	3.0304 mL
	100 mM	0.0970 mL	0.4849 mL	0.9697 mL	2.4244 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.