2. Others Membrane Transporter/Ion Channel MAPK/ERK Pathway Metabolic Enzyme/Protease
  3. Proton Pump ABA Receptor Environmental Pollutants Endogenous Metabolite
  4. Abscisic acid

Abscisic acid  (Synonyms: (S)​-​(+)​-​Abscisic acid; ABA)

Cat. No.: HY-100560 Purity: 99.78%
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Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H+-ATPase) and leads to the plasma membrane depolarization in a Ca2+-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome.

For research use only. We do not sell to patients.

CAS No. : 21293-29-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
50 mg In-stock
100 mg In-stock
500 mg In-stock
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5 g   Get quote  

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Based on 3 publication(s) in Google Scholar

Other Forms of Abscisic acid:

Abscisic acid Related Antibodies

Top Publications Citing Use of Products

    Abscisic acid purchased from MedChemExpress. Usage Cited in: ChemRxiv. 2025 Apr 11.

    The fluorescent imaging of Arabidopsis thaliana treated with various phytohormones (GAs: 1 μM, BR: 1 μg/mL, ABA (Abscisic acid): 1 μM, IAA: 0.1 μg/mL, Kinetin: 0.1 μg/mL, 383 Ethephon: 1 μg/mL) for 3 h prior to incubation with NFP-HDAC(10 μM).

    Abscisic acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 22;15(1):7222.  [Abstract]

    Relative mRNA expression of HBD and HBG1/2 in HEK293T cells expressing ABI1-mCherry-dCas9 fusion proteins targeted to the HS2 enhancer along with PYL1-BFP-dCpf1 fusion proteins targeted to the corresponding gene promoters. Cells were treated with and without abscisic acid (ABA: 100 μM).

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    LANCL2

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H+-ATPase) and leads to the plasma membrane depolarization in a Ca2+-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome[1][2].

    IC50 & Target[1]

    Microbial Metabolite

     

    LANCL2

     

    Cellular Effect
    Cell Line Type Value Description References
    N9 IC50
    68.02 μM
    Compound: 25
    Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    		[PMID: 28073678]
    In Vitro

    In Arabidopsis cell cultures, Abscisic acid ((S)-(+)-Abscisic acid; 10 μM) simultaneously induces rapid alkalinization of the medium and plasma membrane depolarization[1].
    Abscisic acid (10 μM) increases Ca2+ in cytosol of Arabidopsis cell suspension. Abscisic acid does not inhibit proton pumping directly but through an increase in cytosolic Ca2+[1].
    Lanthionine synthetase C-like 2 (LANCL2) is the natural receptor for Abscisic acid. Abscisic acid, both at the organism levels and in specific muscle cells ex vivo, increases both glucose and fatty acid metabolism in the mitochondria, increases glycogen synthesis, activates PI3K independently of insulin and promotes GLUT4 translocation to the cell membrane[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Abscisic acid Related Antibodies
    In Vivo

    Abscisic acid (orally; 0.125 μg/kg/day; for 12 weeks) improves glycemic control[2].
    Abscisic acid (orally; 0.125 μg/kg/day; for 12 weeks) results in significantly lower levels of TNF, MCP-1 and IL-6 in the DIO model. Abscisic acid increases metabolic activity in skeletal muscle[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Diet-induced obesity (DIO) mice at 4 weeks of age[2]
    Dosage: 0.125 µg/kg
    Administration: Orally; daily; for 12 weeks
    Result: Improved glycemic control in a diet-induced model of obesity
    Clinical Trial
    Molecular Weight

    264.32

    Formula

    C15H20O4
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O)/C=C(C)\C=C\[C@@]1(O)C(C)=CC(CC1(C)C)=O
    Structure Classification
    Initial Source

    Widespread
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (378.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 1.25 mg/mL (4.73 mM; ultrasonic and warming and heat to 60°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.7833 mL 18.9165 mL 37.8329 mL
    5 mM 0.7567 mL 3.7833 mL 7.5666 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    C2

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    Volume (final)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 5 mg/mL (18.92 mM); Clear solution

      This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 5 mg/mL (18.92 mM); Clear solution

      This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.78%

    SDS (393 KB)

    COA (247 KB) HNMR (246 KB) RP-HPLC (256 KB) LCMS (339 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 3.7833 mL 18.9165 mL 37.8329 mL 94.5823 mL
    DMSO 5 mM 0.7567 mL 3.7833 mL 7.5666 mL 18.9165 mL
    10 mM 0.3783 mL 1.8916 mL 3.7833 mL 9.4582 mL
    15 mM 0.2522 mL 1.2611 mL 2.5222 mL 6.3055 mL
    20 mM 0.1892 mL 0.9458 mL 1.8916 mL 4.7291 mL
    25 mM 0.1513 mL 0.7567 mL 1.5133 mL 3.7833 mL
    30 mM 0.1261 mL 0.6305 mL 1.2611 mL 3.1527 mL
    40 mM 0.0946 mL 0.4729 mL 0.9458 mL 2.3646 mL
    50 mM 0.0757 mL 0.3783 mL 0.7567 mL 1.8916 mL
    60 mM 0.0631 mL 0.3153 mL 0.6305 mL 1.5764 mL
    80 mM 0.0473 mL 0.2365 mL 0.4729 mL 1.1823 mL
    100 mM 0.0378 mL 0.1892 mL 0.3783 mL 0.9458 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Abscisic acid Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Abscisic acid21293-29-8(S)​-​(+)​-​Abscisic acid ABAProton PumpABA ReceptorEnvironmental PollutantsEndogenous MetaboliteAbscisic Acid (ABA) ReceptorEnvironmental ContaminantsorallyH+-ATPaseCa2+LANCL2insulin-sensitizingdiabetesInhibitorinhibitorinhibit

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