2. Signaling Pathways
  3. MAPK/ERK Pathway
  4. ABA Receptor
  5. LANCL2 Isoform

LANCL2

Lanthionine synthetase component C-like protein 2; LanC like 2; GPR69B; Testis-specific Adriamycin Sensitivity Protein; TASP

LANCL2 (lanthionine synthetase C-like 2) is a broadly expressed immunometabolic signaling protein that regulates inflammatory and metabolic responses through ligand-dependent intracellular signaling mechanisms[1][2]. Mechanistically, LANCL2 functions as a receptor and signaling mediator for abscisic acid (ABA), promoting cAMP-dependent pathways, calcium signaling, and downstream immunoregulatory responses that influence cellular metabolism and immune activation[3][4]. Activation of the LANCL2 pathway is linked to PPARγ-mediated transcriptional programs, regulation of inflammatory cytokine production, and enhancement of regulatory immune cell responses, thereby connecting metabolic control with immune homeostasis[1][5]. In disease models, LANCL2 signaling suppresses intestinal inflammation, supports regulatory macrophage and T-cell differentiation, and ameliorates experimental colitis through modulation of TNF-α, IFN-γ, IL-10, and related immune pathways[5][6]. LANCL2 has also been implicated in adipogenesis and insulin-sensitizing processes, highlighting its relevance to chronic metabolic disorders and diabetes-associated inflammation[1][2]. Compared with the structurally related isoform LANCL1, which has been characterized primarily through structural and glutathione-binding studies, LANCL2 is distinguished by its established role in ABA-dependent signaling and immunometabolic regulation[3][7]. For experimental applications, small-molecule LANCL2 agonists including NSC61610, BT-11, and related compounds have been used to investigate anti-inflammatory mechanisms and therapeutic responses in inflammatory bowel disease and other immune-mediated disease models[4][6].

LANCL2 Related Products (5):

Cat. No. Product Name Effect Purity
  • HY-100560
    Abscisic acid
    		Ligand 99.78%
    Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H+-ATPase) and leads to the plasma membrane depolarization in a Ca2+-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome.
  • HY-102013
    Omilancor
    		Activator 98.44%
    Omilancor (BT-11) is an orally active lanthionine synthetase cyclase-like receptor 2 (LANCL2) activator. Omilancor can be used for the study of psoriasis, inflammatory bowel disease (IBD), and Crohn's disease (CD).
  • HY-100560S
    Abscisic acid-d6
    		Ligand 99.14%
    Abscisic acid-d6 is deuterium labeled Abscisic acid. Abscisic acid inhibits proton pump (H+-ATPase).
  • HY-100560R
    Abscisic acid (Standard)
    		Ligand
    Abscisic acid (Standard) is the analytical standard of Abscisic acid. This product is intended for research and analytical applications. Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H+-ATPase) and leads to the plasma membrane depolarization in a Ca2+-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome.
  • HY-102013R
    Omilancor (Standard)
    		Activator
    Omilancor (Standard) is the analytical standard of Omilancor. This product is intended for research and analytical applications. BT-11 is an orally available LANCL2 binding compound for treating inflammatory bowel disease.