1. Metabolic Enzyme/Protease
    Membrane Transporter/Ion Channel
  2. Endogenous Metabolite
    Proton Pump
  3. Abscisic acid

Abscisic acid (Synonyms: (S)​-​(+)​-​Abscisic acid; ABA)

Cat. No.: HY-100560 Purity: 99.72%
Handling Instructions

Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H+-ATPase) and leads to the plasma membrane depolarization in a Ca2+-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome.

For research use only. We do not sell to patients.

Abscisic acid Chemical Structure

Abscisic acid Chemical Structure

CAS No. : 21293-29-8

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Solution
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 110 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 300 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H+-ATPase) and leads to the plasma membrane depolarization in a Ca2+-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

In Arabidopsis cell cultures, Abscisic acid ((S)-(+)-Abscisic acid; 10 μM) simultaneously induces rapid alkalinization of the medium and plasma membrane depolarization[1].
Abscisic acid (10 μM) increases Ca2+ in cytosol of Arabidopsis cell suspension. Abscisic acid does not inhibit proton pumping directly but through an increase in cytosolic Ca2+[1].
Lanthionine synthetase C-like 2 (LANCL2) is the natural receptor for Abscisic acid. Abscisic acid, both at the organism levels and in specific muscle cells ex vivo, increases both glucose and fatty acid metabolism in the mitochondria, increases glycogen synthesis, activates PI3K independently of insulin and promotes GLUT4 translocation to the cell membrane[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Abscisic acid (orally; 0.125 µg/kg/day; for 12 weeks) improves glycemic control[2].
Abscisic acid (orally; 0.125 µg/kg/day; for 12 weeks) results in significantly lower levels of TNF, MCP-1 and IL-6 in the DIO model. Abscisic acid increases metabolic activity in skeletal muscle[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet-induced obesity (DIO) mice at 4 weeks of age[2]
Dosage: 0.125 µg/kg
Administration: Orally; daily; for 12 weeks
Result: Improved glycemic control in a diet-induced model of obesity
Clinical Trial
Molecular Weight

264.32

Formula

C₁₅H₂₀O₄

CAS No.
SMILES

O=C(O)/C=C(C)\C=C\[[email protected]@]1(O)C(C)=CC(CC1(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (945.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7833 mL 18.9165 mL 37.8329 mL
5 mM 0.7567 mL 3.7833 mL 7.5666 mL
10 mM 0.3783 mL 1.8916 mL 3.7833 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (23.65 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (23.65 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (23.65 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Abscisic acid(S)​-​(+)​-​Abscisic acid ABAEndogenous MetaboliteProton PumporallyH+-ATPaseCa2+LANCL2insulin-sensitizingdiabetesInhibitorinhibitorinhibit

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Abscisic acid
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HY-100560
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