CXCR7 antagonist-1 hydrochloride

Name: CXCR7 antagonist-1 hydrochloride
Brand: MedChemExpress
SKU: HY-139643A
Rating: 5.0 (2 reviews)

Cat. No.: HY-139643A Purity: 99.41%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

CXCR7 antagonist-1 hydrochloride is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 hydrochloride is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases.

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CXCR7 antagonist-1 hydrochloride 화학구조

CAS No. : 2990472-61-0

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 2 publication(s) in Google Scholar

Other Forms of CXCR7 antagonist-1 hydrochloride:

CXCR7 antagonist-1 In-stock

2 Publications Citing Use of MCE CXCR7 antagonist-1 hydrochloride

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All CXCR Isoform Specific Products:

View All Isoforms

CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

View All Adrenergic Receptor Isoform Specific Products:

View All Isoforms

α adrenergic receptor β adrenergic receptor

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target^[1]

CXCR7

In Vitro

CXCR7 antagonist-1 hydrochloride (10 μM, 48 h) restores CXCL11 or respiratory syncytial virus (RSV) infection-induced β2-adrenergic receptor (β2AR) downregulation and the muscle relaxation in infant airway smooth muscle cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	infant airway smooth muscle cells
Concentration:	10 μM
Incubation Time:	48 h
Result:	Inhibited the expression of β2AR.

In Vivo

CXCR7 antagonist-1 hydrochloride (10 μM, intranasal instillation, once a day, 2 doses) inhibits the airway smooth muscle relaxation induced by RSV-infection in BALB/c mouse models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	RSV-infected BALB/c mouse models^[2]
Dosage:	10 μM
Administration:	intranasal instillation, once a day on days 7 and 8 after RSV infection.
Result:	Improved the impaired airway relaxation response to β2AR agonists, restored the airway relaxation function.

분자량

426.87

화학식

C₂₁H₂₀ClFN₆O

CAS No.

2990472-61-0

Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C(C1=NN(C2=CC=C(C=C2)F)C=C1)N[C@@H]3CN(CC3)C4=NC=CN5C4=CC=C5.[H]Cl

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 350 mg/mL (819.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3426 mL	11.7132 mL	23.4263 mL
5 mM	0.4685 mL	2.3426 mL	4.6853 mL
10 mM	0.2343 mL	1.1713 mL	2.3426 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 8.75 mg/mL (20.50 mM); Clear solution

This protocol yields a clear solution of ≥ 8.75 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (87.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 8.75 mg/mL (20.50 mM); Clear solution

This protocol yields a clear solution of ≥ 8.75 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (87.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 8.75 mg/mL (20.50 mM); Clear solution

This protocol yields a clear solution of ≥ 8.75 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (87.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 99.41%

Select Batch:

Data Sheet (280 KB) SDS (252 KB)

COA (257 KB) HNMR (270 KB) RP-HPLC (238 KB) MS (72 KB)

Handling Instructions (2659 KB)

References

[1]. Junfa Fan, et al. Cxcr7 antagonists. Patent WO2014085490A1.

[2]. Zhao C, et al., Infant RSV infection desensitizes β2-adrenergic receptor via CXCL11-CXCR7 signaling in airway smooth muscle. bioRxiv [Preprint]. 2025 Jan 15:2025.01.13.632772. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3426 mL	11.7132 mL	23.4263 mL	58.5658 mL
	5 mM	0.4685 mL	2.3426 mL	4.6853 mL	11.7132 mL
	10 mM	0.2343 mL	1.1713 mL	2.3426 mL	5.8566 mL
	15 mM	0.1562 mL	0.7809 mL	1.5618 mL	3.9044 mL
	20 mM	0.1171 mL	0.5857 mL	1.1713 mL	2.9283 mL
	25 mM	0.0937 mL	0.4685 mL	0.9371 mL	2.3426 mL
	30 mM	0.0781 mL	0.3904 mL	0.7809 mL	1.9522 mL
	40 mM	0.0586 mL	0.2928 mL	0.5857 mL	1.4641 mL
	50 mM	0.0469 mL	0.2343 mL	0.4685 mL	1.1713 mL
	60 mM	0.0390 mL	0.1952 mL	0.3904 mL	0.9761 mL
	80 mM	0.0293 mL	0.1464 mL	0.2928 mL	0.7321 mL
	100 mM	0.0234 mL	0.1171 mL	0.2343 mL	0.5857 mL