Ferric citrate  (Synonyms: Iron(III) citrate; Zerenex)

Ferric citrate (Iron(III) citrate), an orally active iron supplement, is an efficacious phosphate binder. Ferric citratee can be used for iron deficiency anemia and chronic kidney disease (CKD) research^[1][2].

Ferric citrate (Iron(III) citrate; 1 mM; 24 hours) significantly induces CM cell death^[1].
Ferric citrate (Iron(III) citrate; 0.1 mM, 1 mM, 2 mM; 24 hours) increases ROS generation in cardiomyocyte (CM) cells in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Here we compared the effects of Ferric citrate (25 μg/g) administration versus a mineral sufficient control diet using the Col4a3 knockout mouse model of progressive CKD and age-matched wild-type mice. Ferric citrate is given to knockout mice for four weeks beginning at six weeks of age when they had overt chronic kidney disease (CKD), or for six weeks beginning at four weeks of age when they had early CKD. Ferric citrate rescues iron deficiency and anemia in knockout mice regardless of the timing of treatment initiation, and circulating levels and bone expression of FGF23 are reduced. Ferric citrate also improves cardiac function and significantly improves survival^[3].
Ferric citrate is an efficacious and safe phosphate binder that increases iron stores and reduces intravenous iron and erythropoietin-stimulating agent use while maintaining hemoglobin. Ferric citrate can increase transferrin saturation, serum ferritin, and hemoglobin^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

244.94

C₆H₅FeO₇

3522-50-7

Solid

Reddish brown to black

O=C(CC(C([O-])=O)(O)CC([O-])=O)[O-].[Fe+3]

Room temperature in continental US; may vary elsewhere.

Store at room temperature, keep dry and cool

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Yuichi Baba, et al. Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H659-H668.  [Content Brief]

  [2]. Julia B Lewis, et al. Ferric citrate controls phosphorus and delivers iron in patients on dialysis. J Am Soc Nephrol. 2015 Feb;26(2):493-503.  [Content Brief]

  [3]. Connor Francis, et al. Ferric citrate reduces fibroblast growth factor 23 levels and improves renal and cardiac function in a mouse model of chronic kidney disease. Kidney Int. 2019 Dec;96(6):1346-1358.  [Content Brief]