2. Anti-infection
  3. Bacterial Antibiotic
  4. Fosfomycin sodium

Fosfomycin sodium  (Synonyms: MK-0955 sodium)

製品番号: HY-W016420 純度: 99.95%
COA 取扱説明書 Technical Support

Fosfomycin (MK-0955) sodium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin sodium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria.

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Fosfomycin sodium

Fosfomycin sodium 構造式

CAS 番号 : 26016-99-9

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in Water USD 55 在庫あり
Solid
500 mg $50 在庫あり
1 g $70 在庫あり
5 g $126 在庫あり
10 g $170 在庫あり
50 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 14 publication(s) in Google Scholar

Other Forms of Fosfomycin sodium:

Fosfomycin sodium 関連抗体

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製品説明

Fosfomycin (MK-0955) sodium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin sodium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria[1][2].

体外実験

Fosfomycin sodium is an epoxy antibacterial agent. Compared with other antibacterial agents, it acts by inhibiting the early process of cell wall synthesis[1].
Fosfomycin sodium has bactericidal activity against a variety of gram-negative and gram-positive pathogens, including broad-spectrum production β-Bacteria of lactamase and carbapenemase, and against S. aureus strains with an inhibition rate of 90%[1].
Fosfomycin sodium displays extensive tissue penetration, can be used to research of infections of the CNS, soft tissues, bone, lungs, and abscesses[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fosfomycin sodium 関連抗体
体内実験

Fosfomycin sodium (80 mg/kg; i.v.-i.v. or i.v.-p.o.) displays the protective effect on the nephrotoxicity of double beckacin, and is not affected by different administration routes[3].
Pharmacokinetic of Fosfomycin sodium in Rats[4]

Dibekacin Dose (mg) Vdss (l/kg) β (min-1) T1/2 (min) Urinary recovery (%)
30 0.261 0.0244 28.4 85

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fischer 344 rats[3]
Dosage: 320 mg/kg
Administration: Intramuscular injection, 5 schedules: 1 h, 0.5 h earlier than dibekacin, concomitantly, 0.5 h later and 1 h later; 11 days
Result: Reduced polyuria, proteinuria, enzymes and cytosine caused by dibecacin (40 mg/kg), followed by the previous treatment.
Animal Model: Dehydrated Wistar rat with acute renal failure (8-week-old)[4]
Dosage: 120 mg/kg
Administration: Intravenous injection; once
Result: Recovered the exclusion rate of rats basically to normal, and improved the nephrotoxicity parameters.
Protects proximal tubular lysosomes from aminoglycosides by inhibiting myeloid formation and protecting the integrity of lysosomal membrane of rats treated with double bekacin.
分子量

182.02

分子式

C3H5Na2O4P
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

C[C@@H]1O[C@@H]1P(O[Na])(O[Na])=O
Structure Classification
Initial Source

Streptomyces spp.
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : 125 mg/mL (686.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4939 mL 27.4695 mL 54.9390 mL
5 mM 1.0988 mL 5.4939 mL 10.9878 mL
10 mM 0.5494 mL 2.7470 mL 5.4939 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (549.39 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.95%

COA (249 KB) HNMR (214 KB) RP-HPLC (246 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.4939 mL 27.4695 mL 54.9390 mL 137.3475 mL
5 mM 1.0988 mL 5.4939 mL 10.9878 mL 27.4695 mL
10 mM 0.5494 mL 2.7470 mL 5.4939 mL 13.7348 mL
15 mM 0.3663 mL 1.8313 mL 3.6626 mL 9.1565 mL
20 mM 0.2747 mL 1.3735 mL 2.7470 mL 6.8674 mL
25 mM 0.2198 mL 1.0988 mL 2.1976 mL 5.4939 mL
30 mM 0.1831 mL 0.9157 mL 1.8313 mL 4.5783 mL
40 mM 0.1373 mL 0.6867 mL 1.3735 mL 3.4337 mL
50 mM 0.1099 mL 0.5494 mL 1.0988 mL 2.7470 mL
60 mM 0.0916 mL 0.4578 mL 0.9157 mL 2.2891 mL
80 mM 0.0687 mL 0.3434 mL 0.6867 mL 1.7168 mL
100 mM 0.0549 mL 0.2747 mL 0.5494 mL 1.3735 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Fosfomycin sodium Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fosfomycin26016-99-9MK-0955MK0955MK 0955BacterialAntibioticsepsispharmacokineticsafetymultidrug-resistantMDRextensively drug-resistantXDRpan-drug-resistantPDR,antimicrobial activityantibioticdibekacinnephrotoxicitydrug eliminationrenal lysosomedehydrated mouseInhibitorinhibitorinhibit

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