Glycerophosphoinositol choline

Name: Glycerophosphoinositol choline
Brand: MedChemExpress
SKU: HY-B1337B
Rating: 4.5 (0 reviews)

製品番号: HY-B1337B 純度: 98.0%: Data Sheet SDS COA 取扱説明書
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Glycerophosphoinositol choline is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Glycerophosphoinositol choline 構造式

CAS 番号 : 425642-32-6

容量	価格（税別）	在庫状況	数量
5 mg	$775	在庫あり	Estimated Time of Arrival: December 31
10 mg	$1250	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of Glycerophosphoinositol choline:

Glycerophosphoinositol (lysine) お問い合わせ

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Human Endogenous Metabolite Microbial Metabolite

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

Human Endogenous Metabolite

体外実験

Glycerophosphoinositol choline (0 or 70 μM, 4 days) can effectively mitigate apoptosis and maintain cell viability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Rat pheochromocytoma cells PC12
Concentration:	0 or 70 μM
Incubation Time:	4 days
Result:	Showed the cell viability of 94% at 70 μM while cell viability of 83% at 0 μM. Reduced the number of cells with DNA breaks (characteristic of apoptosis) by 8.5% at 70 μM compared to the no treatment group.

体内実験

Glycerophosphoinositol choline (s.c., 0.2 and 100 mg/kg/h, 24 or 48 hours) can reduce postoperative injurious reflexes and effectively decreases tumor necrosis factor (TNF) release from macrophages in female C57/Bl6 mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Postoperative pain model of female C57/Bl6 mice^[2]
Dosage:	0.2 and 100 mg/kg/h
Administration:	Subcutaneous injection, 24 or 48 hours
Result:	Reduced heat hypersensitivity after surgery with maximal efficacy after 48 h treatment and the ED₅₀ value of choline dose was 1.7 mg/kg/h. Reduced hypersensitivity to punctate mechanical stimuli 48 hours after infusion in a dose-dependent manner and with the ED₅₀ value of 4.7 mg/kg/h but not 24 hours.

分子量

437.38

分子式

C₁₄H₃₂NO₁₂P

CAS 番号

425642-32-6

Appearance

Oil

Color

Colorless to light yellow

SMILES

C[N+](C)(C)CCO.OC[C@@H](O)COP(O[C@H]1[C@@H]([C@H]([C@@H]([C@H]([C@H]1O)O)O)O)O)([O-])=O

Structure Classification

Others

Initial Source

Endogenous metabolite

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

H₂O : 5 mg/mL (11.43 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2863 mL	11.4317 mL	22.8634 mL
5 mM	0.4573 mL	2.2863 mL	4.5727 mL
10 mM	0.2286 mL	1.1432 mL	2.2863 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 98.0%

Select Batch:

データシート (276 KB) SDS (252 KB)

COA (253 KB) HNMR (232 KB) MS (70 KB)

取扱説明書 (2659 KB)

参考文献

[1]. M Q Holmes-McNary, et al. Apoptosis is induced by choline deficiency in fetal brain and in PC12 cells. Brain Res Dev Brain Res. 1997 Jul 18;101(1-2):9-16. [Content Brief]

[2]. T J Rowley, et al. Antinociceptive and anti-inflammatory effects of choline in a mouse model of postoperative pain. Br J Anaesth. 2010 Aug;105(2):201-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.2863 mL	11.4317 mL	22.8634 mL	57.1585 mL
	5 mM	0.4573 mL	2.2863 mL	4.5727 mL	11.4317 mL
	10 mM	0.2286 mL	1.1432 mL	2.2863 mL	5.7159 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.