2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Immunology/Inflammation JAK/STAT Signaling Stem Cell/Wnt
  3. Hepcidin Potassium Channel Endogenous Metabolite Interleukin Related STAT
  4. Guanosine 5'-diphosphate sodium, 96% (HPLC)

Guanosine 5'-diphosphate sodium, 96% (HPLC)  (Synonyms: GDP sodium, Type I, 96% (HPLC))

Cat. No.: HY-113066C Pureza: 99.88%
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SDS
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Guanosine 5'-diphosphate (GDP) sodium, 96% (HPLC) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate sodium, 96% (HPLC) is an iron mobilizer, which forms a complex with hepcidin to inhibit the hepcidin-ferroportin (FPN) interaction and modulates the IL-6/stat-3 pathway. Guanosine 5'-diphosphate sodium, 96% (HPLC) ameliorates the Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4. Guanosine 5'-diphosphate sodium, 96% (HPLC) can be used in the research of AI.

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No. CAS : 43139-22-6

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Based on 2 publication(s) in Google Scholar

Other Forms of Guanosine 5'-diphosphate sodium, 96% (HPLC):

Guanosine 5'-diphosphate sodium, 96% (HPLC) Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Guanosine 5'-diphosphate sodium, 96% (HPLC)

Bio/Physico-chemical Assay

    Guanosine 5'-diphosphate sodium, 96% (HPLC) purchased from MedChemExpress. Usage Cited in: Endocrinology. 2023 Aug 1;164(9):bqad114.  [Abstract]

    The mitochondrial respiration of BAT (left) and scWAT (right) was significantly increased at both basal and substrate-induced states in MiR-143 KO mice, and this increase was diminished by guanosine diphosphate (2 mM).

    Guanosine 5'-diphosphate sodium, 96% (HPLC) purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Oct 27;23(21):13058.  [Abstract]

    Guanosine diphosphate (2 mM) inhibited the oxygen consumption of mitochondria isolated from BAT of WT and miR-143 KO mice fed HFD for 1 week.

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    Descripciòn

    Guanosine 5'-diphosphate (GDP) sodium, 96% (HPLC) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate sodium, 96% (HPLC) is an iron mobilizer, which forms a complex with hepcidin to inhibit the hepcidin-ferroportin (FPN) interaction and modulates the IL-6/stat-3 pathway. Guanosine 5'-diphosphate sodium, 96% (HPLC) ameliorates the Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4. Guanosine 5'-diphosphate sodium, 96% (HPLC) can be used in the research of AI[1][2].

    IC50 & Target[2]

    Human Endogenous Metabolite

     

    IL-6

     

    Stat-3

     

    In Vitro

    Guanosine 5'-diphosphate (100 μM-1 mM) sodium, 96% (HPLC) can activate the ATP-sensitive K+ channel in the rabbit portal vein, in the presence of Pinacidil (HY-14290)[1].
    Guanosine 5'-diphosphate (10 μM, 24 h) sodium, 96% (HPLC) inhibits hepcidin-induced FPN internalization in FPN-GFP cell lines (HEK293T) and antagonizes hepcidin to increase the FPN-mediated cellular iron efflux in HepG2 and Caco-2 cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Guanosine 5'-diphosphate sodium, 96% (HPLC) Related Antibodies
    In Vivo

    Guanosine 5'-diphosphate (30 mg/kg, i.p., sigle dose) sodium, 96% (HPLC) increases iron absorption in normal BALB/c mice when combined with iron supplement FeSO4 (2 mg/kg)[2].
    Guanosine 5'-diphosphate (30 mg/kg, i.p., every 24 hours for 2 weeks) sodium, 96% (HPLC) ameliorates the Turpentine-induced AI in mice when combined with FeSO4 (2 mg/kg)[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male BALB/c mice (25 ± 3 g) injected once a week with Turpentine for 2 week[2]
    Dosage: 30 mg/kg
    Administration: i.p., every 24 hours for 2 weeks
    Result: Significantly increased haemoglobin level when combined with FeSO4.
    Significant increased serum iron level when combined with FeSO4.
    Reversed hepcidin-mediated FPN internalization with increased iron accumulation with decreased liver and spleen iron level, when combined with FeSO4.
    Increased FPN level (liver, Spleen, and enterocyte) and reduced iron storage ferritin level (spleen and enterocyte) for effective iron-mediated erythropoiesis thus improving hypoferremia.
    Significantly decreased Hamp mRNA expression and hepcidin expression at transcriptional level, when combined with FeSO4.
    Reduced Stat-3 phosphorylation in mice hepatocyte.
    Peso molecular

    465.18

    Fòrmula

    C10H14N5NaO11P2
    No. CAS
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=P(OP(O)(O[Na])=O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O1
    Initial Source
    Envío

    Room temperature in continental US; may vary elsewhere.
    Almacenamiento

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvente y solubilidad
    In Vitro: 

    H2O : ≥ 100 mg/mL (214.97 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1497 mL 10.7485 mL 21.4971 mL
    5 mM 0.4299 mL 2.1497 mL 4.2994 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Pureza y Documentación

    Purity: 99.88%

    SDS (393 KB)

    COA (250 KB) HNMR (131 KB) CNMR (130 KB) RP-HPLC (224 KB)

    Instrucciones de manejo (2659 KB)
    Referencias

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 2.1497 mL 10.7485 mL 21.4971 mL 53.7426 mL
    5 mM 0.4299 mL 2.1497 mL 4.2994 mL 10.7485 mL
    10 mM 0.2150 mL 1.0749 mL 2.1497 mL 5.3743 mL
    15 mM 0.1433 mL 0.7166 mL 1.4331 mL 3.5828 mL
    20 mM 0.1075 mL 0.5374 mL 1.0749 mL 2.6871 mL
    25 mM 0.0860 mL 0.4299 mL 0.8599 mL 2.1497 mL
    30 mM 0.0717 mL 0.3583 mL 0.7166 mL 1.7914 mL
    40 mM 0.0537 mL 0.2687 mL 0.5374 mL 1.3436 mL
    50 mM 0.0430 mL 0.2150 mL 0.4299 mL 1.0749 mL
    60 mM 0.0358 mL 0.1791 mL 0.3583 mL 0.8957 mL
    80 mM 0.0269 mL 0.1344 mL 0.2687 mL 0.6718 mL
    100 mM 0.0215 mL 0.1075 mL 0.2150 mL 0.5374 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Guanosine 5'-diphosphate sodium, 96% (HPLC) Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Guanosine 5'-diphosphate sodium, 96% (HPLC)43139-22-6GDP sodium, Type I, 96% (HPLC)HepcidinPotassium ChannelEndogenous MetaboliteInterleukin RelatedSTATKcsAILK+ channelIL-6/stat-3 pathwayhepcidininflammationanemiaAICaco-2HepG2Inhibitorinhibitorinhibit

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