2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. L-Carnitine

L-Carnitine  (Synonyms: (R)-Carnitine; Levocarnitine)

Art. -Nr.: HY-B0399 Reinheit: 99.97%
COA
SDS
Handling Instructions Technical Support

L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism.

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L-Carnitine

L-Carnitine Chemische Struktur

CAS. Nr. : 541-15-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Solution
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Based on 20 publication(s) in Google Scholar

Other Forms of L-Carnitine:

L-Carnitine Related Antibodies

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Beschreibung

L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

L-Carnitine ((R)-Carnitine) (125, 250 mg/kg; i.p.) has a more pronounced bronchodilator effect in this chronic murine asthma model, and decreases urinary LTE4 excretion[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Klinische Studie
Molekulargewicht

161.20

Formel

C7H15NO3
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

C[N+](C)(C)C[C@H](O)CC([O-])=O
Structure Classification
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

RT, stored under nitrogen

In solvent -80°C 1 year
-20°C 6 months
Lösungsmittel & Löslichkeit
In Vitro: 

H2O : ≥ 50 mg/mL (310.17 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.2035 mL 31.0174 mL 62.0347 mL
5 mM 1.2407 mL 6.2035 mL 12.4069 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (620.35 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Reinheit & Dokumentation

Purity: 99.97%

SDS (394 KB)

COA (245 KB) HNMR (228 KB) RP-HPLC (214 KB) MS (68 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.2035 mL 31.0174 mL 62.0347 mL 155.0869 mL
5 mM 1.2407 mL 6.2035 mL 12.4069 mL 31.0174 mL
10 mM 0.6203 mL 3.1017 mL 6.2035 mL 15.5087 mL
15 mM 0.4136 mL 2.0678 mL 4.1356 mL 10.3391 mL
20 mM 0.3102 mL 1.5509 mL 3.1017 mL 7.7543 mL
25 mM 0.2481 mL 1.2407 mL 2.4814 mL 6.2035 mL
30 mM 0.2068 mL 1.0339 mL 2.0678 mL 5.1696 mL
40 mM 0.1551 mL 0.7754 mL 1.5509 mL 3.8772 mL
50 mM 0.1241 mL 0.6203 mL 1.2407 mL 3.1017 mL
60 mM 0.1034 mL 0.5170 mL 1.0339 mL 2.5848 mL
80 mM 0.0775 mL 0.3877 mL 0.7754 mL 1.9386 mL
100 mM 0.0620 mL 0.3102 mL 0.6203 mL 1.5509 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Carnitine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Carnitine541-15-1(R)-Carnitine LevocarnitineEndogenous MetaboliteendogenousfattyacidmetabolismmitochondriametabolicimbalanceInhibitorinhibitorinhibit

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