2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial Antibiotic DNA/RNA Synthesis
  4. Phleomycin

Phleomycin is a copper-dependent DNA damaging agent and antibiotic with antitumor activity. Phleomycin binds to DNA and produces ROS in the presence of reducing agents (such as dithiothreitol and glutathione), inducing single-strand and double-strand breaks in DNA. Phleomycin can induce cell apoptosis or mutation and is widely used in cancer inhibition, microbial genetic transformation (as a screening marker to improve fungal transformation efficiency) and DNA repair mechanism research.

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Phleomycin

Phleomycin Estructura química

No. CAS : 11006-33-0

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Based on 2 publication(s) in Google Scholar

Phleomycin Related Antibodies

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Descripciòn

Phleomycin is a copper-dependent DNA damaging agent and antibiotic with antitumor activity. Phleomycin binds to DNA and produces ROS in the presence of reducing agents (such as dithiothreitol and glutathione), inducing single-strand and double-strand breaks in DNA. Phleomycin can induce cell apoptosis or mutation and is widely used in cancer inhibition, microbial genetic transformation (as a screening marker to improve fungal transformation efficiency) and DNA repair mechanism research[1][2][3].

IC50 & Target

Glycopeptide

 

In Vitro

1. Phleomycin (1-25 μg/mL; overnight) can increase the transformation efficiency by more than 10 times in the protoplast transformation experiment of Schizophyllum commune, promote single copy integration, and upregulate the expression of DNA repair genes KU70 and RAD52[2].
2. Phleomycin (2 μg/mL, 10 μg/mL; 90 min-4 h) selectively inhibits DNA synthesis in Escherichia coli (E. coli) and HeLa cells and reduces 3H-thymidine incorporation into DNA. At 20 μg/mL, the DNA degradation activity is significantly lower than that of Mitomycin C (HY-13316)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phleomycin Related Antibodies
No. CAS
Appearance

Solid

Color

Light blue to blue

SMILES

[Phleomycin]
Structure Classification
Initial Source

Streptoalloteichus hindustanus
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvente y solubilidad
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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Phleomycin Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phleomycin11006-33-0BacterialAntibioticDNA/RNA SynthesisantibioticDNA damageglycopeptideDNA-cleavingInhibitorinhibitorinhibit

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Nombre del producto:
Phleomycin
Cat. No.:
HY-126490
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