Phosphonoacetic acid

Name: Phosphonoacetic acid
Brand: MedChemExpress
SKU: HY-128744
Rating: 5.0 (2 reviews)

Cat. No.: HY-128744 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Phosphonoacetic acid is an endogenous metabolite and antiviral agent. Phosphonoacetic acid is active against orthopoxviruses and herpes viruses. Phosphonoacetic acid can inhibit HSV DNA synthesis and virus-specific DNA polymerase activity, and affect the synthesis of late viral proteins.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Phosphonoacetic acid 화학구조

CAS No. : 4408-78-0

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	해외재고보유	Estimated Time of Arrival: December 31
Solid
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 2 publication(s) in Google Scholar

Other Forms of Phosphonoacetic acid:

Phosphonoacetic acid (Standard) 견적 받기

2 Publications Citing Use of MCE Phosphonoacetic acid

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Endogenous Metabolite Isoform Specific Products:

View All Isoforms

Human Endogenous Metabolite Microbial Metabolite

View All HSV Isoform Specific Products:

View All Isoforms

HSV-1 HSV-2 HSV

View All DNA/RNA Synthesis Isoform Specific Products:

View All Isoforms

RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

DNA Polymerase

Human Endogenous Metabolite

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	CC₅₀	3500 3 Compound: Phosphonoacetic acid (PAA)	In vitro cytotoxic concentration in vero cells. In vitro cytotoxic concentration in vero cells.	[PMID: 14584951]
Vero	ED₅₀	240 3 Compound: Phosphonoacetic acid (PAA)	Inhibitory activity against HSV-1 in vero cells Inhibitory activity against HSV-1 in vero cells	[PMID: 14584951]
Vero	CC₅₀	3500 3 Compound: Phosphonoacetic acid (PAA)	In vitro cytotoxic concentration in vero cells. In vitro cytotoxic concentration in vero cells.	[PMID: 14584951]
Vero	ED₅₀	240 3 Compound: Phosphonoacetic acid (PAA)	Inhibitory activity against HSV-1 in vero cells Inhibitory activity against HSV-1 in vero cells	[PMID: 14584951]

In Vitro

Phosphonoacetic acid (≥200 μg/mL; 24 h) inhibits viral growth and DNA synthesis in HSV-1-infected BHK-21 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Phosphonoacetic acid (2% ointment applied topically; twice daily; 4 days) has a protective effect in a rabbit skin lesion model infected with orthopoxvirus^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

140.03

화학식

C₂H₅O₅P

CAS No.

4408-78-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CP(O)(O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Endogenous metabolite

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

H₂O : 260 mg/mL (1856.74 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.1413 mL	35.7066 mL	71.4133 mL
5 mM	1.4283 mL	7.1413 mL	14.2827 mL
10 mM	0.7141 mL	3.5707 mL	7.1413 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (714.13 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 98.0%

Select Batch:

Data Sheet (273 KB) SDS (477 KB)

COA (246 KB) HNMR (217 KB)

Handling Instructions (2659 KB)

References

[1]. Honess RW, et al. Herpes simplex virus resistance and sensitivity to phosphonoacetic acid. J Virol. 1977 Feb;21(2):584-600. [Content Brief]

[2]. Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	7.1413 mL	35.7066 mL	71.4133 mL	178.5332 mL
	5 mM	1.4283 mL	7.1413 mL	14.2827 mL	35.7066 mL
	10 mM	0.7141 mL	3.5707 mL	7.1413 mL	17.8533 mL
	15 mM	0.4761 mL	2.3804 mL	4.7609 mL	11.9022 mL
	20 mM	0.3571 mL	1.7853 mL	3.5707 mL	8.9267 mL
	25 mM	0.2857 mL	1.4283 mL	2.8565 mL	7.1413 mL
	30 mM	0.2380 mL	1.1902 mL	2.3804 mL	5.9511 mL
	40 mM	0.1785 mL	0.8927 mL	1.7853 mL	4.4633 mL
	50 mM	0.1428 mL	0.7141 mL	1.4283 mL	3.5707 mL
	60 mM	0.1190 mL	0.5951 mL	1.1902 mL	2.9756 mL
	80 mM	0.0893 mL	0.4463 mL	0.8927 mL	2.2317 mL
	100 mM	0.0714 mL	0.3571 mL	0.7141 mL	1.7853 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.