2. Membrane Transporter/Ion Channel Autophagy Neuronal Signaling
  3. Autophagy TRP Channel
  4. (rel)-ML-SI3

(rel)-ML-SI3 is one of the active ingredients of ML-SI3 (HY-139426) (another component is (cis)-ML-SI3) that targets three isoforms of TRPML. (rel)-ML-SI3 is an inhibitor of TRPML1 and TRPML3 (IC50=3.1 μM/28.5 μM), and a potent activator of TRPML2 (EC50=3.3 μM).

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(rel)-ML-SI3

(rel)-ML-SI3 Estructura química

No. CAS : 2108567-79-7

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

Other Forms of (rel)-ML-SI3:

(rel)-ML-SI3 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE (rel)-ML-SI3

Ver todos los productos específicos de isoformas TRP Channel:

Ver todas las isoformas
TRPA1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM8 TRPM2 TRPM3 TRPM4 TRPM7 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

  • Actividad biológica

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  • Revisión del cliente

Descripciòn

(rel)-ML-SI3 is one of the active ingredients of ML-SI3 (HY-139426) (another component is (cis)-ML-SI3) that targets three isoforms of TRPML. (rel)-ML-SI3 is an inhibitor of TRPML1 and TRPML3 (IC50=3.1 μM/28.5 μM), and a potent activator of TRPML2 (EC50=3.3 μM)[1][2][3].

IC50 & Target

TRPML1

3.1 μM (IC50)

TRPML2

3.3 μM (EC50)

TRPML3

28.5 μM (IC50)

In Vitro


Table: Activation and inhibition of the three subtypes of TRPML by the ML-SI3-type compounds[3]

Product_Names Catalog_No EC50 for activation [μM] IC50 for inhibition [μM]
TRPML1 TRPML2 TRPML3 TRPML1 TRPML2 TRPML3
(rel)-ML-SI3 HY-139426A - 3.3±1.5 - 3.1±1.5 - 28.5±15.9
(cis)-ML-SI3 / - 9.4±2.7 29.0±4.1 18.5±1.9 - -
(1S,2S)-ML-SI3 HY-134819 - 2.7±1.4 10.8±0.5 5.9±1.7 - -
(1R,2R)-ML-SI3 HY-134819A - - - 1.6±0.7 2.3±1.1 12.5±7.6
Mean values ± SD of at least three independent experiments are shown. -: no effect.
ML-SI3 HY-139426 The mixtrue of (rel)-ML-SI3 and (cis)-ML-SI3

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(rel)-ML-SI3 Related Antibodies
Peso molecular

429.58

Fòrmula

C23H31N3O3S
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=S(N[C@H]1[C@H](N2CCN(C3=C(C=CC=C3)OC)CC2)CCCC1)(C4=CC=CC=C4)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvente y solubilidad
In Vitro: 

DMSO : 50 mg/mL (116.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3279 mL 11.6393 mL 23.2786 mL
5 mM 0.4656 mL 2.3279 mL 4.6557 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Pureza y Documentación

Purity: 98.94%

SDS (393 KB)

COA (253 KB) HNMR (286 KB) LCMS (90 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3279 mL 11.6393 mL 23.2786 mL 58.1964 mL
5 mM 0.4656 mL 2.3279 mL 4.6557 mL 11.6393 mL
10 mM 0.2328 mL 1.1639 mL 2.3279 mL 5.8196 mL
15 mM 0.1552 mL 0.7760 mL 1.5519 mL 3.8798 mL
20 mM 0.1164 mL 0.5820 mL 1.1639 mL 2.9098 mL
25 mM 0.0931 mL 0.4656 mL 0.9311 mL 2.3279 mL
30 mM 0.0776 mL 0.3880 mL 0.7760 mL 1.9399 mL
40 mM 0.0582 mL 0.2910 mL 0.5820 mL 1.4549 mL
50 mM 0.0466 mL 0.2328 mL 0.4656 mL 1.1639 mL
60 mM 0.0388 mL 0.1940 mL 0.3880 mL 0.9699 mL
80 mM 0.0291 mL 0.1455 mL 0.2910 mL 0.7275 mL
100 mM 0.0233 mL 0.1164 mL 0.2328 mL 0.5820 mL
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(rel)-ML-SI3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(rel)-ML-SI32108567-79-7trans-ML-SI3AutophagyTRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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Nombre del producto:
(rel)-ML-SI3
Cat. No.:
HY-139426A
Cantidad:
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