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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

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B16F10 murine melanoma cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Antibiotic (1) Apoptosis (3) Bacterial (4) Biochemical Assay Reagents (2) Caspase (1) Drug Derivative (1) Endogenous Metabolite (3) ERK (1) Fungal (2) Interleukin Related (1) JNK (1) MDM-2/p53 (1) Microphthalmia Associated Transcription Factor (MITF) (1) NF-κB (1) NO Synthase (1) p38 MAPK (2) PARP (1) PD-1/PD-L1 (1) Phosphodiesterase (PDE) (1) PI3K (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2) SARS-CoV (1) TNF Receptor (1) Tyrosinase (3)
By Research Areas:	Cancer (11) Infection (3) Inflammation/Immunology (7) Metabolic Disease (3) Neurological Disease (1)

By Targets:

Akt (1)

Antibiotic (1)

Apoptosis (3)

Bacterial (4)

Biochemical Assay Reagents (2)

Caspase (1)

Drug Derivative (1)

Endogenous Metabolite (3)

ERK (1)

Fungal (2)

Interleukin Related (1)

JNK (1)

MDM-2/p53 (1)

Microphthalmia Associated Transcription Factor (MITF) (1)

NF-κB (1)

NO Synthase (1)

p38 MAPK (2)

PARP (1)

PD-1/PD-L1 (1)

Phosphodiesterase (PDE) (1)

PI3K (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (2)

SARS-CoV (1)

TNF Receptor (1)

Tyrosinase (3)

By Research Areas:

Cancer (11)

Infection (3)

Inflammation/Immunology (7)

Metabolic Disease (3)

Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor AIM2 BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W272217S

Octacosane-d58 n-Octacosane-d₅₈; NSC 5549-d₅₈	Bacterial Endogenous Metabolite	Cancer
Octacosane-d₅₈ is the deuterium labeled Octacosane . Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l .

HY-174830

GJ19	PD-1/PD-L1	Cancer
GJ19 is a PD-L1 inhibitor with an IC₅₀ of 32.06 nM. GJ19 can effectively bind to human/murine PD-L1 protein with K_d values of 171 and 290 nM, respectively. GJ19 concentration-dependently promotes HepG2 cell mortality in a co-culture model of HepG2/hPD-L1 and Jurkat T/hPD-1 cells. GJ19 effectively suppresses tumor growth in a B16-F10 melanoma mouse model. GJ19 can be used for the study of tumor immunotherapy .

HY-W272217

Octacosane n-Octacosane; NSC 5549	Endogenous Metabolite Bacterial	Inflammation/Immunology Cancer
Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC₅₀ concentration of 7.2 mg/l .

HY-N6829

Retusin Quercetin-3,3',4',7-tetramethylether	Tyrosinase Fungal SARS-CoV Apoptosis Reactive Oxygen Species (ROS)	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
Retusin (Quercetin-3,3',4',7-tetramethylether) is a tyrosinase inhibitor, with IC₅₀ values of 50.9 μM and 51.8 μM against mushroom and intracellular tyrosinase, respectively. Retusin also acts as a free radical scavenger, melanogenesis inhibitor, anti-apoptosis agent, neuroprotective agent, antiemetic, antifungal agent, and antiviral agent. Retusin scavenges ABTS• ⁺ and DPPH• free radicals. Retusin can be used in studies related to hyperpigmentation, vomiting, Aspergillus niger infection, and COVID-19 infection .

HY-N1098

Velutin	Tyrosinase p38 MAPK NF-κB Bacterial	Infection Metabolic Disease Inflammation/Immunology
Velutin is a flavonoid. Velutin can be extracted from mistletoe. Velutin inhibits mushroom Tyrosinase activity with an IC₅₀ of 910.1 μM. Velutin inhibits p38 phosphorylation, the NF-κB pathway and the MAPK pathway. Velutin prevents articular cartilage degeneration and subchondral bone loss. Velutin slows down the progression of intervertebral disc degeneration. Velutin exhibits inhibitory effects on melanogenesis, skin whitening, anti-inflammatory, anti-allergic, anti-oxidant and antibacterial activities. Velutin can be used in studies related to pigmented diseases, osteoarthritis and intervertebral disc degeneration .

HY-W001939

4-Acetylbenzoic acid	Biochemical Assay Reagents	Cancer
4-Acetylbenzoic acid is a Zn(II) complex. 4-Acetylbenzoic acid is a derivative of benzoic acid that is commonly used in chemical synthesis. 4-Acetylbenzoic acid has an IC₅₀ of 331.3 μM in murine L929 fibroblasts and an IC₅₀ of 176 μM in metastatic melanoma B16 F10 cell lines .

HY-N8712

Umckalin	p38 MAPK JNK ERK TNF Receptor Interleukin Related PI3K Akt	Inflammation/Immunology
Umckalin is Coumarin (HY-N0709) derivative that exhibits anti-inflammatory properties. Umckalin reduces phosphorylation of p38 MAPK, JNK, and ERK, lowers TNF-α, IL-6, IL-1β, NO, and PGE₂ production. Umckalin can be used for the research of chronic inflammatory diseases .

HY-10615

A-620223 1 Publications Verification	PARP	Cancer
A-620223 is a PARP-1 inhibitor with a K_i of 8 nM against PARP-1 and EC₅₀ of 3 nM in a whole cell assay. A-620223 demonstrates good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with Temozolomide (TMZ) (HY-17364) and in an MX-1 breast xenograph model in combination with Cisplatin (HY-17394). A-620223 can be used for the studies of melanoma and breast cancer .

HY-N14435

Pradimicin Q	Antibiotic Fungal	Infection
Pradimicin Q is an antibiotic. The cytotoxicity (IC₅₀) to human colon HCT-116 cells and murine melanoma B16-F10 cells are 75 and 100 μg/mL, respectively .

HY-W272217R

Octacosane (Standard) n-Octacosane (Standard); NSC 5549 (Standard)	Reference Standards Endogenous Metabolite Bacterial	Inflammation/Immunology Cancer
Octacosane (Standard) is the analytical standard of Octacosane. This product is intended for research and analytical applications. Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l .

HY-120241

Reticulol K 251-1	Phosphodiesterase (PDE)	Cancer
Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma .

HY-149523

Anticancer agent 157	Apoptosis NO Synthase Caspase	Inflammation/Immunology Cancer
Anticancer agent 157 (compound 15) is a NO inhibitor (IC₅₀=0.62 μg/mL) with anti-inflammatory and anticancer activities. Anticancer agent 157 can bind to iNOS (inducible NO synthase) and caspase 8, causing nuclear fragmentation and chromatin condensation, inducing apoptosis. Anticancer agent 157 inhibits HT29 colon cancer cells (IC₅₀=2.45 μg/mL), Hep-G2 liver cancer cells (IC₅₀=3.25 μg/mL), and B16-F10 murine melanoma cells (IC₅₀=3.84 μg/mL) .

HY-W001939R

4-Acetylbenzoic acid (Standard)	Biochemical Assay Reagents Reference Standards	Cancer
4-Acetylbenzoic acid (Standard) is the analytical standard of 4-Acetylbenzoic acid. This product is intended for research and analytical applications. 4-Acetylbenzoic acid is a Zn(II) complex. 4-Acetylbenzoic acid is a derivative of benzoic acid that is commonly used in chemical synthesis. 4-Acetylbenzoic acid has an IC₅₀ of 331.3 μM in murine L929 fibroblasts and an IC₅₀ of 176 μM in metastatic melanoma B16 F10 cell lines .

HY-120996

10(E)-Pentadecenoic acid trans-10-Pentadecenoic acid	Tyrosinase Microphthalmia Associated Transcription Factor (MITF)	Metabolic Disease
10 (E)-Pentadecenoic acid (trans-10-Pentadecenoic acid) is a melanin synthesis inhibitor. 10 (E)-Pentadecenoic acid inhibits nuclear translocation and reduces the protein level of phosphorylated microphthalmia-associated transcription factor (MITF), as well as decreases intracellular tyrosinase activity. 10 (E)-Pentadecenoic acid can be used in the research of skin pigmentation disorders .

HY-183877

YO-2	MDM-2/p53 Apoptosis	Inflammation/Immunology Cancer
YO-2 is a plasmin inhibitor and TP53 upregulator with anti-tumor and apoptosis-inducing activities. YO-2 upregulates the expression of TP53 and the tumor-suppressive miR-103/107, downregulates LRP1, and induces cellular DNA fragmentation and caspase cascade activation. YO-2 effectively blocks the growth of melanoma. YO-2 has been widely used in studies related to melanoma and colon cancer .

HY-P11759

Myr-transportan-Cys	Drug Derivative	Cancer
Myr-transportan-Cys is a derivative of the cell-penetrating peptide Transportan (HY-P1732), and its conjugated myristoyl group (Myr) enhances the interaction between the peptide and cell membranes. Myr-transportan-Cys integrates three key delivery functions: nucleic acid condensation, cell penetration, and endosomal escape. Myr-transportan-Cys can form immunostimulatory tandem peptide nanocomplexes (iTPNCs) for encapsulating and delivering immunostimulatory oligonucleotide cargos to tumors .

Cat. No.	Product Name	Type

HY-W001939

4-Acetylbenzoic acid	Biochemical Assay Reagents
4-Acetylbenzoic acid is a Zn(II) complex. 4-Acetylbenzoic acid is a derivative of benzoic acid that is commonly used in chemical synthesis. 4-Acetylbenzoic acid has an IC₅₀ of 331.3 μM in murine L929 fibroblasts and an IC₅₀ of 176 μM in metastatic melanoma B16 F10 cell lines .

HY-W001939R

4-Acetylbenzoic acid (Standard)	Biochemical Assay Reagents
4-Acetylbenzoic acid (Standard) is the analytical standard of 4-Acetylbenzoic acid. This product is intended for research and analytical applications. 4-Acetylbenzoic acid is a Zn(II) complex. 4-Acetylbenzoic acid is a derivative of benzoic acid that is commonly used in chemical synthesis. 4-Acetylbenzoic acid has an IC₅₀ of 331.3 μM in murine L929 fibroblasts and an IC₅₀ of 176 μM in metastatic melanoma B16 F10 cell lines .

4-Acetylbenzoic acid (Standard)

Biochemical Assay Reagents

4-Acetylbenzoic acid (Standard) is the analytical standard of 4-Acetylbenzoic acid. This product is intended for research and analytical applications. 4-Acetylbenzoic acid is a Zn(II) complex. 4-Acetylbenzoic acid is a derivative of benzoic acid that is commonly used in chemical synthesis. 4-Acetylbenzoic acid has an IC₅₀ of 331.3 μM in murine L929 fibroblasts and an IC₅₀ of 176 μM in metastatic melanoma B16 F10 cell lines .

Cat. No.	Product Name	Target	Research Area

HY-P11759

Myr-transportan-Cys	Drug Derivative	Cancer
Myr-transportan-Cys is a derivative of the cell-penetrating peptide Transportan (HY-P1732), and its conjugated myristoyl group (Myr) enhances the interaction between the peptide and cell membranes. Myr-transportan-Cys integrates three key delivery functions: nucleic acid condensation, cell penetration, and endosomal escape. Myr-transportan-Cys can form immunostimulatory tandem peptide nanocomplexes (iTPNCs) for encapsulating and delivering immunostimulatory oligonucleotide cargos to tumors .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W272217

Octacosane n-Octacosane; NSC 5549	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Cancer	Endogenous Metabolite Bacterial
Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC₅₀ concentration of 7.2 mg/l .

HY-N6829

Retusin Quercetin-3,3',4',7-tetramethylether	Flavonols Structural Classification Monophenols Flavonoids Entada phaseoloides (L.) Merr. Classification of Application Fields Labiatae Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Tyrosinase Fungal SARS-CoV Apoptosis Reactive Oxygen Species (ROS)
Retusin (Quercetin-3,3',4',7-tetramethylether) is a tyrosinase inhibitor, with IC₅₀ values of 50.9 μM and 51.8 μM against mushroom and intracellular tyrosinase, respectively. Retusin also acts as a free radical scavenger, melanogenesis inhibitor, anti-apoptosis agent, neuroprotective agent, antiemetic, antifungal agent, and antiviral agent. Retusin scavenges ABTS• ⁺ and DPPH• free radicals. Retusin can be used in studies related to hyperpigmentation, vomiting, Aspergillus niger infection, and COVID-19 infection .

HY-N1098

Velutin	Structural Classification Flavonoids Microorganisms other families Classification of Application Fields Flavones Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Tyrosinase p38 MAPK NF-κB Bacterial
Velutin is a flavonoid. Velutin can be extracted from mistletoe. Velutin inhibits mushroom Tyrosinase activity with an IC₅₀ of 910.1 μM. Velutin inhibits p38 phosphorylation, the NF-κB pathway and the MAPK pathway. Velutin prevents articular cartilage degeneration and subchondral bone loss. Velutin slows down the progression of intervertebral disc degeneration. Velutin exhibits inhibitory effects on melanogenesis, skin whitening, anti-inflammatory, anti-allergic, anti-oxidant and antibacterial activities. Velutin can be used in studies related to pigmented diseases, osteoarthritis and intervertebral disc degeneration .

HY-N8712

Umckalin	Structural Classification Monophenols Classification of Application Fields Other Diseases Coumarins Phenols Pelargonium hortorum Phenylpropanoids Plants Geraniaceae Disease Research Fields Source Classification	p38 MAPK JNK ERK TNF Receptor Interleukin Related PI3K Akt
Umckalin is Coumarin (HY-N0709) derivative that exhibits anti-inflammatory properties. Umckalin reduces phosphorylation of p38 MAPK, JNK, and ERK, lowers TNF-α, IL-6, IL-1β, NO, and PGE₂ production. Umckalin can be used for the research of chronic inflammatory diseases .

HY-N14435

Pradimicin Q	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Fungal
Pradimicin Q is an antibiotic. The cytotoxicity (IC₅₀) to human colon HCT-116 cells and murine melanoma B16-F10 cells are 75 and 100 μg/mL, respectively .

HY-W272217R

Octacosane (Standard) n-Octacosane (Standard); NSC 5549 (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Bacterial
Octacosane (Standard) is the analytical standard of Octacosane. This product is intended for research and analytical applications. Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l .

HY-120241

Reticulol K 251-1	Microorganisms Phenols Polyphenols Source Classification	Phosphodiesterase (PDE)
Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma .

Cat. No.	Product Name	Chemical Structure

HY-W272217S

Octacosane-d58
Octacosane-d₅₈ is the deuterium labeled Octacosane . Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l .

Octacosane-d58

Octacosane-d₅₈ is the deuterium labeled Octacosane . Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l .

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B16F10 murine melanoma cells

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