Reticulol  (Synonyms: K 251-1)

Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma^[1][2].

Reticulol (25-200 μM) shows a potent cytotoxicity against the human lung tumor cell line A427 and the mouse melanoma cell line B16F10^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reticulol (10 mg/kg, 50 mg/kg; iv; day 3 and day 5 after tumor implanted) inhibits tumor growth in mice bearing B16F10 melanoma, and shows lung metastasis-blocking effect^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

222.19

C₁₁H₁₀O₅

26246-41-3

O=C1C2=C(O)C(OC)=C(O)C=C2C=C(C)O1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Furutani Y, et al. Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. J Antibiot (Tokyo). 1975 Jul;28(7):558-60.  [Content Brief]

  [2]. Lim DS, et al. Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma. Chemotherapy. 2003 Jun;49(3):146-53.  [Content Brief]