26246-41-3
Chemical Structure
Reticulol
Synonym(s): K 251-1
- CAS No.: 26246-41-3
- Formula:C11H10O5
- Molecular Weight:222.19
IUPAC Name: 6,8-dihydroxy-7-methoxy-3-methyl-1H-isochromen-1-one
InChIKey: LREZRXWUEZCZRU-UHFFFAOYSA-N
SMILES: O=C1C2=C(O)C(OC)=C(O)C=C2C=C(C)O1
Biological Activity: Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma[1][2].
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Reticulol | Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma. | |||||||||||||||||||||
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- [1]. Furutani Y, et al. Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. J Antibiot (Tokyo). 1975 Jul;28(7):558-60. [Content Brief]
- [2]. Lim DS, et al. Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma. Chemotherapy. 2003 Jun;49(3):146-53. [Content Brief]
Keywords
