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Results for "

CR1

" in MedChemExpress (MCE) Product Catalog:

32

Inhibitors & Agonists

1

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3

Inhibitory Antibodies

2

Natural
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5

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13

Antibodies

8

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13848
    Rugocrixan
    Maximum Cited Publications
    21 Publications Verification

    AZD8797; KAND567

    CX3CR1 CXCR Inflammation/Immunology Endocrinology Cancer
    AZD8797 (KAND567) is an allosteric non-competitive and orally active antagonist of the human CX3CR1 receptor; antagonizes CX3CR1 and CXCR2 with Kis of 3.9 and 2800 nM, respectively [1].
    Rugocrixan
  • HY-P9928
    Alirocumab
    1 Publications Verification

    REGN 727; SAR 236553

    PCSK9 NOD-like Receptor (NLR) Keap1-Nrf2 HMG Family NF-κB CX3CR1 Cardiovascular Disease Cancer
    Alirocumab is an anti-PCSK9 human monoclonal antibody. Alirocumab inhibits PCSK9. Alirocumab reduces NLRP3 inflammasome, regulates Nrf2/HO-1, HMGB1/NF-κB and Fractalkine/CX3CR1. Alirocumab increases the ability of the liver to bind LDL-cholesterol (LDL-C) and reduces levels of LDL-C in blood. Alirocumab improves atherosclerosis and inflammation [1] .
    Alirocumab
  • HY-123918
    JMS-17-2
    15+ Cited Publications

    CX3CR1 Endocrinology Cancer
    JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells [1].
    JMS-17-2
  • HY-W074890
    Palmitoylglycine
    1 Publications Verification

    N-palmitoyl glycine

    Calcium Channel NO Synthase Neurological Disease Inflammation/Immunology
    Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA [1] .
    Palmitoylglycine
  • HY-160421

    Apoptosis Inflammation/Immunology Cancer
    TREM2-IN-1 (OPA) is a TREM2 inhibitor derived from oxaliplatin and artesunate. TREM2-IN-1 can relieves immunosuppressive tumor microenvironment and enhancing chemical anticancer efficiency. TREM2-IN-1 deters the tumor growth in mice models bearing MC38 colorectal tumor by reducing the number of CD206 + and CX3CR1 + immunosuppressive macrophages. TREM2-IN-1 also promotes the expansion and infiltration of immunostimulatory dendritic, cytotoxic T and natural killer cells [1].
    TREM2-IN-1
  • HY-15724
    Vercirnon
    3 Publications Verification

    GSK-1605786; CCX282-B; Traficet-EN

    CCR Ligands for Target Protein for PROTAC Inflammation/Immunology Endocrinology
    Vercirnon (GSK1605786A) is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon inhibits CCR9-mediated Ca 2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 μM for all). Vercirnon is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively [1].
    Vercirnon
  • HY-136453
    CR-1-31-B
    10+ Cited Publications

    Eukaryotic Initiation Factor (eIF) Apoptosis Cancer
    CR-1-31-B is a synthetic rocaglate and a potent eIF4A inhibitor. CR-1-31-B exhibits powerful inhibitory effects over eIF4A by perturbing the interaction between eIF4A and RNA, sequentially impeding initiation during protein synthesis. CR-1-31-B perturbs association of Plasmodium falciparum eIF4A (PfeIF4A) with RNA. CR-1-31-B induces apoptosis of neuroblastoma and gallbladder cancer cells [1] .
    CR-1-31-B
  • HY-P9928A
    Alirocumab (anti-PCSK9)
    1 Publications Verification

    REGN 727(anti-PCSK9); SAR 236553(anti-PCSK9)

    PCSK9 NOD-like Receptor (NLR) Keap1-Nrf2 HMG Family NF-κB CX3CR1 Cardiovascular Disease Cancer
    Alirocumab (anti-PCSK9) is an anti-PCSK9 human monoclonal antibody. Alirocumab (anti-PCSK9) inhibits PCSK9. Alirocumab (anti-PCSK9) reduces NLRP3 inflammasome, regulates Nrf2/HO-1, HMGB1/NF-κB and Fractalkine/CX3CR1. Alirocumab (anti-PCSK9) increases the ability of the liver to bind LDL-cholesterol (LDL-C) and reduces levels of LDL-C in blood. Alirocumab (anti-PCSK9) improves atherosclerosis and inflammation [1] .
    Alirocumab (anti-PCSK9)
  • HY-107456
    E6130
    2 Publications Verification

    CX3CR1 Inflammation/Immunology Endocrinology
    E6130 is an orally active and highly selective CX3CR1 modulator, that may be effective for treatment of inflammatory bowel disease.
    E6130
  • HY-175746

    CX3CR1 Cardiovascular Disease
    AZD0233 is an orally active CX3CR1 antagonist. AZD0233 modulates the CX3CR1/CX3CL1 signaling axis via immunomodulatory effects. AZD0233 has improved physicochemical properties, metabolic stability, low toxicity and CYP inhibition. AZD0233 improves cardiac function and reduces macrophages and fibrotic scar in mice model of dilated cardiomyopathy. AZD0233 can be used for cardiovascular diseases like dilated cardiomyopathy research [1].
    AZD0233
  • HY-P99404

    E6011

    CXCR Inflammation/Immunology Cancer
    Quetmolimab (E6011) is a humanized anti-Fractalkine (CX3CL1) monoclonal antibody. Quetmolimab binds to membrane-bound and soluble Fractalkine, neutralizes Fractalkine-induced migration of CX3CR1-expressing cells, mediates target-bound complex elimination from serum. Quetmolimab suppresses free soluble Fractalkine levels in cynomolgus monkeys, with target engagement linked to increased serum total Fractalkine concentration. Quetmolimab can be used for the research of Crohn’s disease, rheumatoid arthritis, and primary biliary cholangitis [1].
    Quetmolimab
  • HY-15724A
    Vercirnon sodium
    3 Publications Verification

    GSK-1605786 sodium; CCX282-B sodium; Traficet-EN sodium

    CCR Inflammation/Immunology Endocrinology
    Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon sodium inhibits CCR9-mediated Ca 2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon sodium is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 μM for all). Vercirnon sodium is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively [1].
    Vercirnon sodium
  • HY-RS03131

    Small Interfering RNA (siRNA) Others

    CR1 Human Pre-designed siRNA Set A contains three designed siRNAs for CR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CR1 Human Pre-designed siRNA Set A
    CR1 Human Pre-designed siRNA Set A
  • HY-W074890R

    N-palmitoyl glycine (Standard)

    Reference Standards Calcium Channel NO Synthase Neurological Disease Inflammation/Immunology
    Palmitoylglycine (Standard) is the analytical standard of Palmitoylglycine. This product is intended for research and analytical applications. Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA[1][2][3].
    Palmitoylglycine (Standard)
  • HY-RS03380

    Small Interfering RNA (siRNA) Others

    Cx3cr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cx3cr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cx3cr1 Mouse Pre-designed siRNA Set A
    Cx3cr1 Mouse Pre-designed siRNA Set A
  • HY-P2969

    Endogenous Metabolite Metabolic Disease
    Complement factor I is a serine protease that downregulates complement activity in the fluid phase and/or on cell surfaces in conjunction with one of its cofactors, factor H (FH), complement receptor 1 (CR1/CD35), C4 binding protein (C4BP) or membrane cofactor protein (MCP/CD46) [1].
    Complement factor I
  • HY-168975

    CX3CR1 Inflammation/Immunology
    Fosrugocrixan is an antagonist for CX3C chemokine receptor 1 (CX3CR1) that exhibits anti-inflammatory activity [1].
    Fosrugocrixan
  • HY-136453A

    Mucin Drug Isomer Cancer
    CR-1-30-B is an inactive enantiomer of CR-1-31-B. CR-1-30-B, as a control, is inactive against eIF4A and has no apparent effect on the induction of MUC1-C translation [1].
    CR-1-30-B
  • HY-RS03132

    Small Interfering RNA (siRNA) Others

    CR1L Human Pre-designed siRNA Set A contains three designed siRNAs for CR1L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CR1L Human Pre-designed siRNA Set A
    CR1L Human Pre-designed siRNA Set A
  • HY-RS03379

    Small Interfering RNA (siRNA) Others

    CX3CR1 Human Pre-designed siRNA Set A contains three designed siRNAs for CX3CR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CX3CR1 Human Pre-designed siRNA Set A
    CX3CR1 Human Pre-designed siRNA Set A
  • HY-RS03381

    Small Interfering RNA (siRNA) Others

    Cx3cr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cx3cr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cx3cr1 Rat Pre-designed siRNA Set A
    Cx3cr1 Rat Pre-designed siRNA Set A
  • HY-D3080

    CR-1
  • HY-RS14330

    Small Interfering RNA (siRNA) Others

    TDGF1 Human Pre-designed siRNA Set A contains three designed siRNAs for TDGF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TDGF1 Human Pre-designed siRNA Set A
    TDGF1 Human Pre-designed siRNA Set A
  • HY-173451

    Trace Amine-associated Receptor (TAAR) 5-HT Receptor Neurological Disease
    TAAR1/5-H-2CR agonist-1 (compound 21b) is a TAAR1 and 5-HT2CR dual agonist with EC50s of 0.022 and 0.246 μM, respectively. TAAR1/5-H-2CR agonist-1 can used in the study of schizophrenia and Alzheimer's Disease [1].
    TAAR1/5-H-2CR agonist-1
  • HY-123918A

    CX3CR1 Endocrinology Cancer
    JMS-17-2 hydrochloride is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 hydrochloride impairs metastatic seeding and colonization of breast cancer cells [1].
    JMS-17-2 hydrochloride
  • HY-15724R

    GSK-1605786 (Standard); CCX282-B (Standard); Traficet-EN (Standard)

    CCR Reference Standards Inflammation/Immunology Endocrinology
    Vercirnon (Standard) is the analytical standard of Vercirnon. This product is intended for research and analytical applications. Vercirnon (GSK1605786A) is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 μM for all). Vercirnon is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively [1].
    Vercirnon (Standard)
  • HY-15724AR

    GSK-1605786 sodium (Standard); CCX282-B sodium (Standard); Traficet-EN sodium (Standard)

    CCR Reference Standards Inflammation/Immunology Endocrinology
    Vercirnon (sodium) (Standard) is the analytical standard of Vercirnon (sodium). This product is intended for research and analytical applications. Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon sodium inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon sodium is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 μM for all). Vercirnon sodium is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively [1].
    Vercirnon sodium (Standard)
  • HY-181016

    CX3CR1 Cardiovascular Disease
    CX3CR1-IN-2 (Compound 77) is a CX3CR1 inhibitor with an IC50 of 0.04 μM. CX3CR1-IN-2 can block the interaction between CX3CR1 and its ligand fractalkine (CX3CL1). CX3CR1-IN-2 can be used for research of cardiovascular disease, such as heart failure and cardiomyopathy [1].
    CX3CR1-IN-2
  • HY-179653

    CX3CR1 Cardiovascular Disease
    CX3CR1-IN-1 (Compound 24) is a CX3CR1 inhibitor with an IC50 of 9 nM. CX3CR1-IN-1 can be used for the study of cardiovascular diseases [1].
    CX3CR1-IN-1
  • HY-174731

    mRNA Inflammation/Immunology
    Human CX3CR1 mRNA encodes the human C-X3-C motif chemokine receptor 1 (CX3CR1) protein, a receptor for fractalkine. CX3CR1 is also a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS.
    Human CX3CR1 mRNA
  • HY-RS18588

    Small Interfering RNA (siRNA) Others

    Cr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cr2 Mouse Pre-designed siRNA Set A
    Cr2 Mouse Pre-designed siRNA Set A
  • HY-107456R

    Reference Standards CX3CR1 Inflammation/Immunology Endocrinology
    E6130 (Standard) is the analytical standard of E6130 (HY-107456). This product is intended for research and analytical applications. E6130 is an orally active and highly selective CX3CR1 modulator, that may be effective for treatment of inflammatory bowel disease.
    E6130 (Standard)

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