2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. Quetmolimab

Quetmolimab  (Synonyms: E6011)

Cat. No.: HY-P99404 Purity: 99.9%
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Quetmolimab (E6011) is a humanized anti-Fractalkine (CX3CL1) monoclonal antibody. Quetmolimab binds to membrane-bound and soluble Fractalkine, neutralizes Fractalkine-induced migration of CX3CR1-expressing cells, mediates target-bound complex elimination from serum. Quetmolimab suppresses free soluble Fractalkine levels in cynomolgus monkeys, with target engagement linked to increased serum total Fractalkine concentration. Quetmolimab can be used for the research of Crohn’s disease, rheumatoid arthritis, and primary biliary cholangitis.

For research use only. We do not sell to patients.

CAS No. : 2084037-83-0

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Description

Quetmolimab (E6011) is a humanized anti-Fractalkine (CX3CL1) monoclonal antibody. Quetmolimab binds to membrane-bound and soluble Fractalkine, neutralizes Fractalkine-induced migration of CX3CR1-expressing cells, mediates target-bound complex elimination from serum. Quetmolimab suppresses free soluble Fractalkine levels in cynomolgus monkeys, with target engagement linked to increased serum total Fractalkine concentration. Quetmolimab can be used for the research of Crohn’s disease, rheumatoid arthritis, and primary biliary cholangitis[1].

Isotype

Human IgG2 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

CX3CL1/Fractalkine
In Vitro

Quetmolimab (E6011) inhibits fractalkine-induced migration of human CX3CR1-transfected B300.19 mouse B-lymphocyte precursors, with a minimum active concentration of 3.2 ng/mL for 10% maximal suppression of free soluble FKN from baseline[1].
Quetmolimab binds to soluble human fractalkine with a mean equilibrium dissociation constant of 0.27 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Quetmolimab Related Antibodies
In Vivo

Quetmolimab (E6011) (0.05-100 mg/kg; i.v.; single infusion) at doses from 0.05 to 100 mg/kg in cynomolgus monkeys engages its target (fractalkine) as confirmed by increased total serum FKN concentrations, with a near-complete maximum effect (EMAX = 0.974) on modulating free soluble FKN elimination[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys (median body weight 3.44 kg)[1]
Dosage: 0.05-100 mg/kg
Administration: i.v.; single infusion
Result: Exhibited a triphasic elimination profile, with dose-dependent increases in exposure where area under the concentration-time curve (AUC) increased more than proportionally to dose.
Increased serum total FKN concentration, confirming target engagement.
Reached a maximum effect (EMAX) of 0.974, indicating near-complete suppression of free soluble FKN elimination at sufficient concentrations.
Gene ID

6376  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

144.72 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Quetmolimab]
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 kappa
Biological Activity
  • Immobilized Fractalkine/CX3CL1 Protein, Human (HY-P7180) can bind Quetmolimab. The EC50 for this effect is 3.65 ng/mL.
Purity & Documentation
References
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Quetmolimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quetmolimab2084037-83-0E6011E 6011E-6011CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsprimary biliary cholangitisCX3CR1FractalkineCX3CL1rheumatoid arthritisB300.19 mouse B-lymphocyte precursorsCrohn’s diseasecynomolgus monkeysInhibitorinhibitorinhibit

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