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  4. Monoclonal Antibodies Recombinant Antibodies
  5. RANK Antibody (YA1607)

RANK Antibody (YA1607) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RANK.

For research use only. We do not sell to patients.

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50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
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250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

RANK Antibody (YA1607) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RANK.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 66 kDa;
Observed band size: 80 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human RANK aa1-56/616.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis (PubMed:9878548). Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2 (By similarity). Involved in the regulation of interactions between T-cells and dendritic cells (By similarity)
Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Membrane raft; Cell membrane; Single-pass type I membrane protein
Expression：
Tissue_specificity:This gene is widely expressed in various tissues throughout the body, with high expression levels in skeletal muscle, thymus, liver, colon, small intestine, and adrenal glands.
Isoforms & Post-Translational Modification：Q9Y6Q6 has 6 isomers: Q9Y6Q6-1: 66034 Da (predicted); Q9Y6Q6-2: 32318 Da (predicted); Q9Y6Q6-3: 36399 Da (predicted); Q9Y6Q6-4: 28965 Da (predicted); Q9Y6Q6-5: 56402 Da (predicted); Q9Y6Q6-6: 64552 Da (predicted).
Subunit：Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer (By similarity). Part of a complex composed of EEIG1, TNFRSF11A/RANK, PLCG2, GAB2, TEC and BTK; complex formation increases in the presence of TNFSF11/RANKL (PubMed:23478294). Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6 (PubMed:9774460). Interacts (via cytoplasmic domain) with GAB2 (PubMed:15750601). Interacts (via cytoplasmic domain); with EEIG1 (via N-terminus); when in the presence of TNFSF11/RANKL (By similarity)
Database

Entrez Gene: 8792 Human

SwissProt: Q9Y6Q6 Human

OMIM: 174810 Human

Research Field

Immunology
Synonyms
CD265; FEO; LOH18CR1; mRANK; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; TNFRSF11A; TRANCER
Documentation
User Guide for Antibodies (1077 KB)

RANK Antibody (YA1607) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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RANK Antibody (YA1607)
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HY-P81862
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