RANK Antibody (YA1607)
(Synonyms: CD265; FEO; LOH18CR1; mRANK; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; TNFRSF11A; TRANCER)RANK Antibody (YA1607) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RANK.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
RANK Antibody (YA1607) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RANK.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 80 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 66 kDa
A synthesized peptide derived from human RANK aa1-56/616.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RANK receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2. Involved in the regulation of interactions between T-cells and dendritic cells[1].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Membrane raft; Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:This gene is widely expressed in various tissues throughout the body, with high expression levels in skeletal muscle, thymus, liver, colon, small intestine, and adrenal glands. -
Isoforms & Post-Translational Modification
Q9Y6Q6 has 6 isomers: Q9Y6Q6-1: 66034 Da (predicted); Q9Y6Q6-2: 32318 Da (predicted); Q9Y6Q6-3: 36399 Da (predicted); Q9Y6Q6-4: 28965 Da (predicted); Q9Y6Q6-5: 56402 Da (predicted); Q9Y6Q6-6: 64552 Da (predicted).
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Subunit
Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer (By similarity). Part of a complex composed of EEIG1, TNFRSF11A/RANK, PLCG2, GAB2, TEC and BTK; complex formation increases in the presence of TNFSF11/RANKL (PubMed:23478294). Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6 (PubMed:9774460). Interacts (via cytoplasmic domain) with GAB2 (PubMed:15750601). Interacts (via cytoplasmic domain); with EEIG1 (via N-terminus); when in the presence of TNFSF11/RANKL (By similarity)
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SwissProt ID
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Synonyms
CD265; FEO; LOH18CR1; mRANK; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; TNFRSF11A; TRANCER
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Research Field
Immunology
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