TNFRSF11A - TNF receptor superfamily member 11a Gene

Homo sapiens

Also known as FEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1; TRANCE-R

Gene ID: 8792 | Gene type: protein coding

About TNFRSF11A

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:62,325,310-62,391,288 (from NCBI)

This gene has 4 transcripts (splice variants), 493 orthologues, 21 paralogues and is associated with 9 phenotypes. Biased expression in duodenum (RPKM 14.3), colon (RPKM 11.6) and 10 other tissues.

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]

TNFRSF11A Products(10)

mRNA	Protein	Name
NM_001270950.2	NP_001257879.1	tumor necrosis factor receptor superfamily member 11A isoform 3 precursor
XM_017026065.2	XP_016881554.1	tumor necrosis factor receptor superfamily member 11A isoform X3
XM_011526244.3	XP_011524546.1	tumor necrosis factor receptor superfamily member 11A isoform X1
NM_001270949.2	NP_001257878.1	tumor necrosis factor receptor superfamily member 11A isoform 2 precursor
NM_001270951.2	NP_001257880.1	tumor necrosis factor receptor superfamily member 11A isoform 4 precursor
XM_011526245.3	XP_011524547.1	tumor necrosis factor receptor superfamily member 11A isoform X2
NM_001278268.2	NP_001265197.1	tumor necrosis factor receptor superfamily member 11A isoform 5 precursor
XM_017026066.2	XP_016881555.1	tumor necrosis factor receptor superfamily member 11A isoform X4
NM_003839.4	NP_003830.1	tumor necrosis factor receptor superfamily member 11A isoform 1 precursor
XM_017026064.2	XP_016881553.1	tumor necrosis factor receptor superfamily member 11A isoform X2

TNFRSF11A Protein Structure

TNFR_c6

0
100
200
300
400
500
616 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor receptor superfamily member 11A

Paget disease of bone 2	TRANCE receptor
familial expansile osteolysis	loss of heterozygosity, 18, chromosomal region 1
osteoclast differentiation factor receptor	receptor activator of NF-KB
receptor activator of nuclear factor-kappa B	tumor necrosis factor receptor superfamily, member 11a, NFKB activator

Recombinant TNFRSF11A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71687	RANK/TNFRSF11A Protein, Human (His)	Q9Y6Q6 (28L-202K)	≥95%
HY-P71912	RANK/TNFRSF11A Protein, Human	Q9Y6Q6 (Q29-K202)	≥95%
HY-P72484	RANK/TNFRSF11A Protein, Human (HEK293, His)	Q9Y6Q6 (I30-P212)	≥95%

Related Diseases

Diseases

Alias

Paget Disease Of Bone 5, Juvenile-Onset

Juvenile Paget Disease	Hyperostosis Corticalis Deformans Juvenilis
Jpd	Hereditary Hyperphosphatasia
Hyperphosphatasemia With Bone Disease	Hyperphosphatasia, Familial Idiopathic
PDB5	Hyperphosphatasemia, Chronic Congenital Idiopathic
Osteoectasia, Familial	Jpg
Familial Osteoectasia	Paget Disease, Juvenile
Hyperostosid Corticalis Deformans Juvenilis	Juvenile Pagets Disease
Paget Disease Juvenile Type	Chronic Congenital Idiopathic Hyperphosphatasemia
Familial Idiopathic Hyperphosphatasemia	Idiopathic Hyperphosphatasia
Juvenile Paget'S Disease	Osteochalasia Desmalis Familiaris
Osteoectasia With Hyperphosphatasia	Chronic Congenital Idiopathic Hyperphosphatasia
Paget Disease Of Bone, Type 5, Juvenile-Onset	Juvenile Osteitis Deformans

Fanconi Anemia, Complementation Group P

Fanconi Anemia Complementation Group P

FANCP

Osteopetrosis, Autosomal Recessive 2

OPTB2	Autosomal Recessive Osteopetrosis 2
Osteopetrosis, Mild Autosomal Recessive Form	Osteoclast-Poor Osteopetrosis
Osteopetrosis, Osteoclast-Poor	Mild Autosomal Recessive Form Osteopetrosis
Osteopetrosis Autosomal Recessive 2	Autosomal Recessive Osteopetrosis Type 2
Osteopetrosis Osteoclast-Poor	Osteopetrosis, Autosomal Recessive, Type 2

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Glutaric Aciduria Iii

Glutaryl-Coa Oxidase Deficiency	Ga Iii
Glutaric Acidemia Type 3	GA3
Glutaric Aciduria Type 3	Glutaric Aciduria 3
Glutaric Acidemia Type Iii	Glutaric Aciduria Type Iii

Fibrous Dysplasia

Fibrous Dysplasia Of Bone

Myopathy, Centronuclear, 1

Autosomal Dominant Centronuclear Myopathy	CNM1
Centronuclear Myopathy 1	Ad-Cnm
Myopathy, Centronuclear, Autosomal Dominant	Myotubular Myopathy, Autosomal Dominant
Centronuclear Myopathy, Autosomal, Modifier Of	Autosomal Dominant Myotubular Myopathy
Dnm2-Related Centronuclear Myopathy	Centronuclear Myopathy Autosomal Dominant
Myopathies, Structural, Congenital	Myopathy, Centronuclear, Type 1

Mammary Paget'S Disease

Paget'S Disease	Mammary Paget Disease
Paget'S Disease Of The Breast	Paget Disease Of The Breast
Paget'S Disease Of The Nipple	Paget'S Disease, Mammary
Paget Cell Neoplasm	Paget Disease Of The Nipple
Pagets Disease Mammary	Osteitis Deformans

Giant Cell Reparative Granuloma

Central Giant Cell Granuloma	Central Giant Cell Reparative Granuloma Of Jaw
Central Giant Cell Granuloma	Granuloma, Giant Cell
Granuloma, Giant Cell Reparative	Giant Cell Lesion Of Small Bones
Giant Cell Granuloma, Nos

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Osteopetrosis, Autosomal Dominant 1

OPTA1	Autosomal Dominant Osteopetrosis 1
Autosomal Dominant Osteopetrosis Type 1	Osteopetrosis Autosomal Dominant Type 1
Osteopetrosis, Autosomal Dominant, Type I	Osteopetrosis, Autosomal Dominant, Type 1

Febrile Seizures, Familial, 1

FEB1	Convulsions, Familial Febrile, 1
Familial Febrile Seizures 1	Familial Febrile Convulsions 1

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Bone Remodeling Disease

Osteomyelitis

Osteopetrosis, Autosomal Recessive 7

OPTB7	Autosomal Recessive Osteopetrosis 7
Autosomal Recessive Osteoclast-Poor Osteopetrosis With Hypogammaglobulinemia	Autosomal Recessive Osteopetrosis Type 7
Osteoclast-Poor Osteopetrosis With Hypogammaglobulinemia	Osteopetrosis-Hypogammaglobulinemia Syndrome
Osteopetrosis, Osteoclast-Poor, With Hypogammaglobulinemia	Osteopetrosis Autosomal Recessive 7
Osteopetrosis Osteoclast-Poor With Hypogammaglobulinemia	Osteopetrosis, Autosomal Recessive, Type 7

Arthropathy

Ankylosis Of Ankle And Foot Joint	Ankylosis Of Forearm Joint
Ankylosis Of Hand Joint	Ankylosis Of Joint Of Ankle And/Or Foot
Ankylosis Of Joint Of Forearm	Ankylosis Of Joint Of Hand
Ankylosis Of Joint Of Lower Leg	Ankylosis Of Joint Of Multiple Sites
Ankylosis Of Joint Of Pelvic Region And Thigh	Ankylosis Of Joint Of Shoulder Region
Ankylosis Of Joint Of Upper Arm	Ankylosis Of Lower Leg Joint
Ankylosis Of Multiple Joints	Ankylosis Of Upper Arm Joint
Infectious Arthropathy	Joint Ankylosis Of The Ankle And Foot
Joint Ankylosis Of The Ankle And/Or Foot	Joint Ankylosis Of The Forearm
Joint Ankylosis Of The Hand	Joint Ankylosis Of The Lower Leg
Joint Ankylosis Of The Pelvic Region And Thigh	Joint Ankylosis Of The Shoulder Region
Joint Ankylosis Of The Upper Arm	Joint Diseases
Joint Disease	Arthropathy Associated With Infection

Epilepsy, Idiopathic Generalized 17

Febrile Seizures, Familial, 2	EIG17
Familial Febrile Seizures 2	FEB2
Epilepsy, Idiopathic Generalized, Susceptibility To, 17	Familial Febrile Convulsions 2
Convulsions, Familial Febrile, 2

Scoliosis

Benign Giant Cell Tumor

Giant Cell Tumors

Paget Disease Of Bone 2, Early-Onset

PDB2	Paget Disease Of Bone, Type 2, Early-Onset

Paget'S Disease Of Bone

Osteitis Deformans	Paget Disease Of Bone
Osseous Paget'S Disease	Paget Disease Of Bone, Familial
Bone Paget Disease	Familial Paget'S Disease Of Bone
Paget'S Bone Disease	Familial Paget Disease Of Bone
Paget Disease, Bone	Pdb
Pagets Bone Disease

Tooth Resorption

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Parotid Gland Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Parotid Gland

Familial Expansile Osteolysis

FEO	Mccabe Disease
Osteolysis, Familial Expansile	Polyostotic Osteolytic Dysplasia, Hereditary Expansile
Hepod	Expansile Osteolysis, Familial
Eof	Hereditary Expansile Polyostotic Osteolytic Dysplasia

Disseminated Chorioretinitis

Osteopetrosis

Albers-Schonberg Disease	Marble Bone Disease
Osteopetroses	Marble Bones
Osteopetrosis And Related Disorders	Congenital Osteopetrosis
Marble Bone	Albers-Schoenberg Disease
Albers-Schonberg Osteopetrosis	Osteosclerosis Fragilis
Ivory Bones

Craniometaphyseal Dysplasia, Autosomal Dominant

Craniometaphyseal Dysplasia	CMDD
Cmdj	Cmd
Autosomal Dominant Craniometaphyseal Dysplasia	Craniometaphyseal Dysplasia, Jackson Type
Craniometaphyseal Dysplasia Jackson Type	Autosomal Recessive Craniometaphyseal Dysplasia
Cmdr	Dysplasia, Craniometaphyseal, Autosomal Dominant
Craniometaphyseal Dysplasia, Autosomal Recessive Type

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Myeloma, Multiple

Multiple Myeloma	Kahler Disease
Myelomatosis	Plasma Cell Myeloma
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Multiple Myeloma, Susceptibility To	Myeloma - Multiple
Kahler'S Disease	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Primary Progressive Multiple Sclerosis

Ppms	Primary-Progressive Ms
Multiple Sclerosis, Primary Progressive

Dysosteosclerosis

Adult-Onset Myasthenia Gravis

Adult-Onset Acquired Myasthenia

Adult-Onset Autoimmune Myasthenia Gravis

Osteogenic Sarcoma

Osteosarcoma	OSRC
Osteosarcoma, Somatic	Neoplasms, Bone Tissue
Bone Tissue Neoplasm	Osteoid Sarcoma
Skeletal Sarcoma	Osteosarcoma Of Bone
Bone Sarcoma

Periostitis

Root Resorption

Bone Disease

Bone Diseases	Skeletal Disease
Skeletal Disorder	Disorder Of Skeletal System

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS14799	TNFRSF11A Human Pre-designed siRNA Set A	/	Unkown
HY-RS14800	Tnfrsf11a Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS14801	Tnfrsf11a Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TNFRSF11A	VGNC	VGNC:104252
Canis familiaris	TNFRSF11A	VGNC	VGNC:47654
Felis catus	TNFRSF11A	VGNC	VGNC:66402
Mus musculus	TNFRSF11A	MGD	MGI:1314891
Bos taurus	TNFRSF11A	VGNC	VGNC:56374
Rattus norvegicus	TNFRSF11A	RGD	RGD:1563614
Others	TNFRSF11A	NCBI