TNFRSF11A - TNF receptor superfamily member 11a Gene

Also Known as FEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1; TRANCE-R

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8792

About TNFRSF11A

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:62,325,310-62,391,288 (from NCBI)

This gene has 4 transcripts (splice variants), 493 orthologues, 21 paralogues and is associated with 9 phenotypes. Biased expression in duodenum (RPKM 14.3), colon (RPKM 11.6) and 10 other tissues.

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]

TNFRSF11A Products (10)

mRNA	Protein	Name
NM_001270950.2	NP_001257879.1	tumor necrosis factor receptor superfamily member 11A isoform 3 precursor
XM_017026065.2	XP_016881554.1	tumor necrosis factor receptor superfamily member 11A isoform X3
XM_011526244.3	XP_011524546.1	tumor necrosis factor receptor superfamily member 11A isoform X1
NM_001270949.2	NP_001257878.1	tumor necrosis factor receptor superfamily member 11A isoform 2 precursor
NM_001270951.2	NP_001257880.1	tumor necrosis factor receptor superfamily member 11A isoform 4 precursor
XM_011526245.3	XP_011524547.1	tumor necrosis factor receptor superfamily member 11A isoform X2
NM_001278268.2	NP_001265197.1	tumor necrosis factor receptor superfamily member 11A isoform 5 precursor
XM_017026066.2	XP_016881555.1	tumor necrosis factor receptor superfamily member 11A isoform X4
NM_003839.4	NP_003830.1	tumor necrosis factor receptor superfamily member 11A isoform 1 precursor
XM_017026064.2	XP_016881553.1	tumor necrosis factor receptor superfamily member 11A isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cytokine binding	IPI IPI: Inferred from physical interaction	9367155	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10075662	GOA
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	9367155	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adaptive immune response	IMP IMP: Inferred from mutant phenotype	18606301	GOA
involved in osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	18606301	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12296995	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	18606301	GOA
involved in positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	12296995	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	9367155	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	12296995	GOA
involved in tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18606301	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	9367155	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFRSF11A Protein Structure

TNFR_c6

0
100
200
300
400
500
616 a.a.

Protein Preferred Names	Protein Names
tumor necrosis factor receptor superfamily member 11A	Paget disease of bone 2 TRANCE receptor familial expansile osteolysis loss of heterozygosity, 18, chromosomal region 1 osteoclast differentiation factor receptor receptor activator of NF-KB receptor activator of nuclear factor-kappa B tumor necrosis factor receptor superfamily, member 11a, NFKB activator

TNFRSF11A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNFRSF11A	Q9Y6Q6	O14788-PRO_0000034515	Homo sapiens	O14788-PRO_0000034515	SPR	23333834
Intra	TNFRSF11A	Q9Y6Q6	O14788-PRO_0000034515	Homo sapiens	O14788-PRO_0000034515	ELISA	23333834

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFRSF11A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71687	RANK/TNFRSF11A Protein, Human (His)	Q9Y6Q6 (L28-K202)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P71912	RANK/TNFRSF11A Protein, Human	Q9Y6Q6-1 (Q29-K202)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72484	RANK/TNFRSF11A Protein, Human (HEK293, His)	Q9Y6Q6 (I30-P212)	≥ 95%, as determined by reducing SDS-PAGE.

TNFRSF11A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81862	RANK Antibody (YA1607)	WB	Human
HY-P84907	RANK Antibody (YA4604)	FC, ELISA	Human, Mouse, Rat
HY-P84907A	RANK Antibody (YA4604)(PBS only)	WB, FC, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Paget Disease Of Bone 5, Juvenile-Onset	Juvenile Paget Disease Hyperostosis Corticalis Deformans Juvenilis Jpd Hereditary Hyperphosphatasia Hyperphosphatasemia With Bone Disease Hyperphosphatasia, Familial Idiopathic PDB5 Hyperphosphatasemia, Chronic Congenital Idiopathic Osteoectasia, Familial Jpg Familial Osteoectasia Paget Disease, Juvenile Hyperostosid Corticalis Deformans Juvenilis Juvenile Pagets Disease Paget Disease Juvenile Type Chronic Congenital Idiopathic Hyperphosphatasemia Familial Idiopathic Hyperphosphatasemia Idiopathic Hyperphosphatasia Juvenile Paget'S Disease Osteochalasia Desmalis Familiaris Osteoectasia With Hyperphosphatasia Chronic Congenital Idiopathic Hyperphosphatasia Paget Disease Of Bone, Type 5, Juvenile-Onset Juvenile Osteitis Deformans
Fanconi Anemia, Complementation Group P	Fanconi Anemia Complementation Group P FANCP
Osteopetrosis, Autosomal Recessive 2	OPTB2 Autosomal Recessive Osteopetrosis 2 Osteopetrosis, Mild Autosomal Recessive Form Osteoclast-Poor Osteopetrosis Osteopetrosis, Osteoclast-Poor Mild Autosomal Recessive Form Osteopetrosis Osteopetrosis Autosomal Recessive 2 Autosomal Recessive Osteopetrosis Type 2 Osteopetrosis Osteoclast-Poor Osteopetrosis, Autosomal Recessive, Type 2
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Glutaric Aciduria Iii	Glutaryl-Coa Oxidase Deficiency Ga Iii Glutaric Acidemia Type 3 GA3 Glutaric Aciduria Type 3 Glutaric Aciduria 3 Glutaric Acidemia Type Iii Glutaric Aciduria Type Iii
Fibrous Dysplasia	Fibrous Dysplasia Of Bone
Myopathy, Centronuclear, 1	Autosomal Dominant Centronuclear Myopathy CNM1 Centronuclear Myopathy 1 Ad-Cnm Myopathy, Centronuclear, Autosomal Dominant Myotubular Myopathy, Autosomal Dominant Centronuclear Myopathy, Autosomal, Modifier Of Autosomal Dominant Myotubular Myopathy Dnm2-Related Centronuclear Myopathy Centronuclear Myopathy Autosomal Dominant Myopathies, Structural, Congenital Myopathy, Centronuclear, Type 1
Mammary Paget'S Disease	Paget'S Disease Mammary Paget Disease Paget'S Disease Of The Breast Paget Disease Of The Breast Paget'S Disease Of The Nipple Paget'S Disease, Mammary Paget Cell Neoplasm Paget Disease Of The Nipple Pagets Disease Mammary Osteitis Deformans
Giant Cell Reparative Granuloma	Central Giant Cell Granuloma Central Giant Cell Reparative Granuloma Of Jaw Central Giant Cell Granuloma Granuloma, Giant Cell Granuloma, Giant Cell Reparative Giant Cell Lesion Of Small Bones Giant Cell Granuloma, Nos
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Osteopetrosis, Autosomal Dominant 1	OPTA1 Autosomal Dominant Osteopetrosis 1 Autosomal Dominant Osteopetrosis Type 1 Osteopetrosis Autosomal Dominant Type 1 Osteopetrosis, Autosomal Dominant, Type I Osteopetrosis, Autosomal Dominant, Type 1
Febrile Seizures, Familial, 1	FEB1 Convulsions, Familial Febrile, 1 Familial Febrile Seizures 1 Familial Febrile Convulsions 1
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Bone Remodeling Disease
Osteomyelitis
Osteopetrosis, Autosomal Recessive 7	OPTB7 Autosomal Recessive Osteopetrosis 7 Autosomal Recessive Osteoclast-Poor Osteopetrosis With Hypogammaglobulinemia Autosomal Recessive Osteopetrosis Type 7 Osteoclast-Poor Osteopetrosis With Hypogammaglobulinemia Osteopetrosis-Hypogammaglobulinemia Syndrome Osteopetrosis, Osteoclast-Poor, With Hypogammaglobulinemia Osteopetrosis Autosomal Recessive 7 Osteopetrosis Osteoclast-Poor With Hypogammaglobulinemia Osteopetrosis, Autosomal Recessive, Type 7
Arthropathy	Ankylosis Of Ankle And Foot Joint Ankylosis Of Forearm Joint Ankylosis Of Hand Joint Ankylosis Of Joint Of Ankle And/Or Foot Ankylosis Of Joint Of Forearm Ankylosis Of Joint Of Hand Ankylosis Of Joint Of Lower Leg Ankylosis Of Joint Of Multiple Sites Ankylosis Of Joint Of Pelvic Region And Thigh Ankylosis Of Joint Of Shoulder Region Ankylosis Of Joint Of Upper Arm Ankylosis Of Lower Leg Joint Ankylosis Of Multiple Joints Ankylosis Of Upper Arm Joint Infectious Arthropathy Joint Ankylosis Of The Ankle And Foot Joint Ankylosis Of The Ankle And/Or Foot Joint Ankylosis Of The Forearm Joint Ankylosis Of The Hand Joint Ankylosis Of The Lower Leg Joint Ankylosis Of The Pelvic Region And Thigh Joint Ankylosis Of The Shoulder Region Joint Ankylosis Of The Upper Arm Joint Diseases Joint Disease Arthropathy Associated With Infection
Epilepsy, Idiopathic Generalized 17	Febrile Seizures, Familial, 2 EIG17 Familial Febrile Seizures 2 FEB2 Epilepsy, Idiopathic Generalized, Susceptibility To, 17 Familial Febrile Convulsions 2 Convulsions, Familial Febrile, 2
Scoliosis
Benign Giant Cell Tumor	Giant Cell Tumors
Paget Disease Of Bone 2, Early-Onset	PDB2 Paget Disease Of Bone, Type 2, Early-Onset
Paget'S Disease Of Bone	Osteitis Deformans Paget Disease Of Bone Osseous Paget'S Disease Paget Disease Of Bone, Familial Bone Paget Disease Familial Paget'S Disease Of Bone Paget'S Bone Disease Familial Paget Disease Of Bone Paget Disease, Bone Pdb Pagets Bone Disease
Tooth Resorption
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Parotid Gland Adenoid Cystic Carcinoma	Adenoid Cystic Carcinoma Of Parotid Gland
Familial Expansile Osteolysis	FEO Mccabe Disease Osteolysis, Familial Expansile Polyostotic Osteolytic Dysplasia, Hereditary Expansile Hepod Expansile Osteolysis, Familial Eof Hereditary Expansile Polyostotic Osteolytic Dysplasia
Disseminated Chorioretinitis
Osteopetrosis	Albers-Schonberg Disease Marble Bone Disease Osteopetroses Marble Bones Osteopetrosis And Related Disorders Congenital Osteopetrosis Marble Bone Albers-Schoenberg Disease Albers-Schonberg Osteopetrosis Osteosclerosis Fragilis Ivory Bones
Craniometaphyseal Dysplasia, Autosomal Dominant	Craniometaphyseal Dysplasia CMDD Cmdj Cmd Autosomal Dominant Craniometaphyseal Dysplasia Craniometaphyseal Dysplasia, Jackson Type Craniometaphyseal Dysplasia Jackson Type Autosomal Recessive Craniometaphyseal Dysplasia Cmdr Dysplasia, Craniometaphyseal, Autosomal Dominant Craniometaphyseal Dysplasia, Autosomal Recessive Type
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Primary Progressive Multiple Sclerosis	Ppms Primary-Progressive Ms Multiple Sclerosis, Primary Progressive
Dysosteosclerosis
Adult-Onset Myasthenia Gravis	Adult-Onset Acquired Myasthenia Adult-Onset Autoimmune Myasthenia Gravis
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Periostitis
Root Resorption
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14800	Tnfrsf11a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14801	Tnfrsf11a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14799	TNFRSF11A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TNFRSF11A	VGNC	VGNC:104252
Canis familiaris	TNFRSF11A	VGNC	VGNC:47654
Felis catus	TNFRSF11A	VGNC	VGNC:66402
Mus musculus	TNFRSF11A	MGD	MGI:1314891
Bos taurus	TNFRSF11A	VGNC	VGNC:56374
Rattus norvegicus	TNFRSF11A	RGD	RGD:1563614
Others	TNFRSF11A	NCBI