RANK Antibody (YA4604)(PBS only)
(Synonyms: FEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1; TRANCE-R)RANK Antibody (YA4604) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RANK.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, FC, ELISA
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:400 | 1:10000 |
Product Details
RANK Antibody (YA4604) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RANK.
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Host Mouse
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 80 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 66 kDa
Purified recombinant fragment of human TNFRSF11A (AA: extra 30-212) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RANK receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2. Involved in the regulation of interactions between T-cells and dendritic cells[1].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Membrane raft; Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:This gene is widely expressed in various tissues throughout the body, with high expression levels in skeletal muscle, thymus, liver, colon, small intestine, and adrenal glands. -
Isoforms & Post-Translational Modification
Q9Y6Q6 has 6 isomers: Q9Y6Q6-1: 66034 Da (predicted); Q9Y6Q6-2: 32318 Da (predicted); Q9Y6Q6-3: 36399 Da (predicted); Q9Y6Q6-4: 28965 Da (predicted); Q9Y6Q6-5: 56402 Da (predicted); Q9Y6Q6-6: 64552 Da (predicted).
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Subunit
Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer (By similarity). Part of a complex composed of EEIG1, TNFRSF11A/RANK, PLCG2, GAB2, TEC and BTK; complex formation increases in the presence of TNFSF11/RANKL (PubMed:23478294). Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6 (PubMed:9774460). Interacts (via cytoplasmic domain) with GAB2 (PubMed:15750601). Interacts (via cytoplasmic domain); with EEIG1 (via N-terminus); when in the presence of TNFSF11/RANKL (By similarity)
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SwissProt ID
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Synonyms
FEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1; TRANCE-R
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