1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. JMS-17-2

JMS-17-2 

Cat. No.: HY-123918 Purity: 99.59%
Handling Instructions

JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM.

For research use only. We do not sell to patients.

JMS-17-2 Chemical Structure

JMS-17-2 Chemical Structure

CAS No. : 1380392-05-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM[1].

IC50 & Target[1]

CX3CR1

0.32 nM (IC50)

In Vivo

JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice[1].

Animal Model: SCID mice (~25g) with MDA-231 xenograft[1]
Dosage: 10 mg/kg
Administration: Aministered i.p.; twice a day for three weeks
Result: Caused a dramatic reduction of tumors in both skeleton and visceral organs.
Molecular Weight

419.95

Formula

C₂₅H₂₆ClN₃O

CAS No.

1380392-05-1

SMILES

O=C1C2=CC=CN2C3=C(C=CC=C3)N1CCCN4CCC(C5=CC=C(Cl)C=C5)CC4

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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JMS-17-2
Cat. No.:
HY-123918
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