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JMS-17-2 

Cat. No.: HY-123918 Purity: 99.59%
Handling Instructions

JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells.

For research use only. We do not sell to patients.

JMS-17-2 Chemical Structure

JMS-17-2 Chemical Structure

CAS No. : 1380392-05-1

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of JMS-17-2:

Top Publications Citing Use of Products
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Description

JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells[1].

IC50 & Target

IC50: 0.32 nM (CX3CR1)[1]

In Vivo

JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice[1].

Animal Model: SCID mice (~25g) with MDA-231 xenograft[1]
Dosage: 10 mg/kg
Administration: Aministered i.p.; twice a day for three weeks
Result: Caused a dramatic reduction of tumors in both skeleton and visceral organs.
Molecular Weight

419.95

Formula

C₂₅H₂₆ClN₃O

CAS No.

1380392-05-1

SMILES

O=C1C2=CC=CN2C3=C(C=CC=C3)N1CCCN4CCC(C5=CC=C(Cl)C=C5)CC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (59.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3812 mL 11.9062 mL 23.8124 mL
5 mM 0.4762 mL 2.3812 mL 4.7625 mL
10 mM 0.2381 mL 1.1906 mL 2.3812 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.95 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.59%

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Keywords:

JMS-17-2OthersInhibitorinhibitorinhibit

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Product Name:
JMS-17-2
Cat. No.:
HY-123918
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