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Cat. No.: HY-123918A

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JMS-17-2 hydrochloride

18 Cited Publications

Customer Review

Based on 18 publication(s) in Google Scholar

JMS-17-2 hydrochloride is a potent and selective CX3CR1 antagonist with an IC₅₀ of 0.32 nM. JMS-17-2 hydrochloride impairs metastatic seeding and colonization of breast cancer cells.

For research use only. We do not sell to patients.

CAS No.: 2341841-07-2
Formula: C₂₅H₂₇Cl₂N₃O
Molecular Weight:456.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

JMS-17-2 hydrochloride Chemical Structure

CAS No.: 2341841-07-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (18)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

JMS-17-2 hydrochloride is a potent and selective CX3CR1 antagonist with an IC₅₀ of 0.32 nM. JMS-17-2 hydrochloride impairs metastatic seeding and colonization of breast cancer cells^[1].

IC₅₀ & Target

IC50: 0.32 nM (CX3CR1)^[1]

In Vivo

JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SCID mice (~25g) with MDA-231 xenograft^[1]
Dosage:

10 mg/kg
Administration:

Aministered i.p.; twice a day for three weeks
Result:

Caused a dramatic reduction of tumors in both skeleton and visceral organs.

Chemical Information

CAS No. 2341841-07-2
Molecular Weight 456.41
Formula C₂₅H₂₇Cl₂N₃O
SMILES

O=C1C2=CC=CN2C3=C(C=CC=C3)N1CCCN4CCC(C5=CC=C(Cl)C=C5)CC4.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (18)

All In Vivo Efficacy StudyCell Migration/Invasion AssayHistological Imaging/StainingIF

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Journal Impact Factor

Cancer Discov

Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype. [Abstract]

2025 Sep 4;15(9):1819-1834. PMID: 40530504

JMS-17-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2025 Sep 4;15(9):1819-1834. [Abstract]

JMS-17-2 (10 mg/kg; IP; five times per week ) combination with αPD-1 led to a dramatic inhibition of tumor growth in C57BL/6 mice.

JMS-17-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2025 Sep 4;15(9):1819-1834. [Abstract]

JMS-17-2 (10 mg/kg; IP; five times per week ) combination with αPD-1 significantly decreased in NK cell abundance at the tumor rim and an increased infiltration of CD45⁺ immune cells (including CD8⁺ T cells) in C57BL/6 mice.
Cancer Res

Postoperative plasmacytoid dendritic cells secrete IFN-α to promote recruitment of myeloid-derived suppressor cells and drive hepatocellular carcinoma recurrence. [Abstract]

2022 Nov 15;82(22):4206-4218. PMID: 36112065
Nat Commun

Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice. [Abstract]

2024 Jan 10;15(1):449. PMID: 38200023
Neuron

Reactive oligodendrocytes promote glioblastoma progression through CCL5/CCR5-mediated glioma stem cell maintenance. [Abstract]

2026 Jan 21;114(2):237-249.e10. PMID: 41570802
Gut Microbes

Fusobacterium nucleatum-driven CX3CR1+ PD-L1+ phagocytes route to tumor tissues and reshape tumor microenvironment. [Abstract]

2025 Dec;17(1):2442037. PMID: 39710592

JMS-17-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2442037. [Abstract]

JMS-17-2 (10 nM; 1+12 h) significantly inhibited both Fn- and Fn1792-stimulated PMNs migration to endothelial cells.

JMS-17-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2442037. [Abstract]

JMS-17-2 (10 mg/kg; IP; daily) attenuated the stimulating effects of Fn1792 on tumor progression in MC38 tumor-bearing C57BL/6 mice.

JMS-17-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2442037. [Abstract]

JMS-17-2 (10 mg/kg; IP; daily) decreased the Fn1792 induced the number of lung metastatic in MC38 tumor-bearing C57BL/6 mice. Representative images of H&E staining of lung and quantitative analysis.
Cancer Lett

Direct interaction of platelet with tumor cell aggravates hepatocellular carcinoma metastasis by activating TLR4/ADAM10/CX3cl1 axis. [Abstract]

2024 Mar 31:585:216674. PMID: 38280480
J Neuroinflammation

Microglia sustain anterior cingulate cortex neuronal hyperactivity in nicotine-induced pain. [Abstract]

2023 Mar 21;20(1):81. PMID: 36944965
Cell Rep

A microglial activation cascade across cortical regions underlies secondary mechanical hypersensitivity to amputation. [Abstract]

2024 Feb 17;43(2):113804. PMID: 38368612
Cell Prolif

Repetitive Transcranial Magnetic Stimulation Induces Cognitive Recovery in Alzheimer's Disease via GABAergic Neuron Activation of the Cx3cl1-Cx3cr1 Axis. [Abstract]

2025 Dec;58(12):e70061. PMID: 40415257
PLoS Biol

Microglial activity during postnatal development is required for infantile amnesia in mice. [Abstract]

2026 Jan 20;24(1):e3003538. PMID: 41557596
Food Funct

Resveratrol inhibits respiratory syncytial virus replication by targeting heparan sulfate proteoglycans. [Abstract]

2024 Feb 19;15(4):1948-1962. PMID: 38270052
Sci Rep

Chronic inflammation promotes gastric cancer progression via ADAM10-mediated cleavage of CX3CL1. [Abstract]

2026 Feb 15;16(1):9169. PMID: 41691064
Microbiol Spectr

New insight into the epidemiological trends of respiratory syncytial virus infection and the underlying anti-respiratory syncytial virus mechanisms of andrographolide: integrating Global Burden of Disease database, network pharmacological analysis, and in vitro experiments. [Abstract]

2025 Nov 13:e0234125. PMID: 41230964
Stem Cells Int

Nucleus Pulposus Cells Induce M2 Polarization of RAW264.7 via CX3CL1/CX3CR1 Pathway and M2 Macrophages Promote Proliferation and Anabolism of Nucleus Pulposus Cells. [Abstract]

2023 Feb 20:2023:6400162. PMID: 37274023

JMS-17-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2023 Feb 20:2023:6400162. [Abstract]

CX3CL1 remarkably induces M2 polarization of RAW264.7 , while this effect is measurably reversed by JMS-17-2.
Placenta

High expression of CX3CL1/CX3CR1 at the mother-fetus interface of preeclampsia inhibits trophoblast invasion and migration. [Abstract]

2024 Aug 21:156:30-37. PMID: 39236525
Exp Ther Med

CX3CL1/CX3CR1 axis alleviates inflammation and apoptosis in human nucleus pulpous cells via M2 macrophage polarization. [Abstract]

2023 Jun 7;26(1):359. PMID: 37324510
bioRxiv

Microglial plasticity across development mediates infantile amnesia. [Abstract]

2025 Oct 17:2025.10.17.683060. PMID: 41279042
Heliyon

CX3CL1 and its receptor CX3CR1 interact with RhoA signaling to induce paclitaxel resistance in gastric cancer. [Abstract]

2024 Apr 1;10(7):e29100. PMID: 38601629

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shen F, et al. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells. Mol Cancer Res. 2016 Jun;14(6):518-27. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

JMS-17-2 hydrochloride

18 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (18)
Purity & Documentation
References

1/16
1/16

JMS-17-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2025 Sep 4;15(9):1819-1834. [Abstract]

Customer Validation
JMS-17-2 (10 mg/kg; IP; five times per week ) combination with αPD-1 led to a dramatic inhibition of tumor growth in C57BL/6 mice.
1/16

JMS-17-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2025 Sep 4;15(9):1819-1834. [Abstract]

Customer Validation
JMS-17-2 (10 mg/kg; IP; five times per week ) combination with αPD-1 significantly decreased in NK cell abundance at the tumor rim and an increased infiltration of CD45⁺ immune cells (including CD8⁺ T cells) in C57BL/6 mice.
1/16

JMS-17-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2442037. [Abstract]

Customer Validation
JMS-17-2 (10 nM; 1+12 h) significantly inhibited both Fn- and Fn1792-stimulated PMNs migration to endothelial cells.
1/16

JMS-17-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2442037. [Abstract]

Customer Validation
JMS-17-2 (10 mg/kg; IP; daily) attenuated the stimulating effects of Fn1792 on tumor progression in MC38 tumor-bearing C57BL/6 mice.
1/16

JMS-17-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2442037. [Abstract]

Customer Validation
JMS-17-2 (10 mg/kg; IP; daily) decreased the Fn1792 induced the number of lung metastatic in MC38 tumor-bearing C57BL/6 mice. Representative images of H&E staining of lung and quantitative analysis.
1/16

JMS-17-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2023 Feb 20:2023:6400162. [Abstract]

Customer Validation
CX3CL1 remarkably induces M2 polarization of RAW264.7 , while this effect is measurably reversed by JMS-17-2.

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JMS-17-2 hydrochloride

Publications Citing Use of MedChemExpress (MCE) JMS-17-2 hydrochloride

Biological Activity

Chemical Information

Publications (18)

Purity & Documentation

References

Calculators

Help & FAQs

JMS-17-2 hydrochloride Related Classifications

HY-123918A Related Classifications