2. Immunology/Inflammation
  3. CX3CR1
  4. JMS-17-2 hydrochloride

JMS-17-2 hydrochloride is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 hydrochloride impairs metastatic seeding and colonization of breast cancer cells.

For research use only. We do not sell to patients.

JMS-17-2 hydrochloride Chemical Structure

JMS-17-2 hydrochloride Chemical Structure

CAS No. : 2341841-07-2

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JMS-17-2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

    JMS-17-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2023 Feb 20.

    CX3CL1 remarkably induces M2 polarization of RAW264.7 , while this effect is measurably reversed by JMS-17-2.

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    Description

    JMS-17-2 hydrochloride is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 hydrochloride impairs metastatic seeding and colonization of breast cancer cells[1].

    IC50 & Target

    IC50: 0.32 nM (CX3CR1)[1]
    In Vivo

    JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: SCID mice (~25g) with MDA-231 xenograft[1]
    Dosage: 10 mg/kg
    Administration: Aministered i.p.; twice a day for three weeks
    Result: Caused a dramatic reduction of tumors in both skeleton and visceral organs.
    Molecular Weight

    456.41

    Formula

    C25H27Cl2N3O
    CAS No.
    SMILES

    O=C1C2=CC=CN2C3=C(C=CC=C3)N1CCCN4CCC(C5=CC=C(Cl)C=C5)CC4.[H]Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    JMS-17-2 hydrochloride Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    JMS-17-22341841-07-2CX3CR1CX3C chemokine receptor1GPR13fractalkine receptorInhibitorinhibitorinhibit

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    Product Name:
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