1. Others
  2. Others
  3. JMS-17-2 hydrochloride

JMS-17-2 hydrochloride 

Cat. No.: HY-123918A
Handling Instructions

JMS-17-2 hydrochloride is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 hydrochloride impairs metastatic seeding and colonization of breast cancer cells.

For research use only. We do not sell to patients.

JMS-17-2 hydrochloride Chemical Structure

JMS-17-2 hydrochloride Chemical Structure

CAS No. : 2341841-07-2

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other In-stock Forms of JMS-17-2 hydrochloride:

Other Forms of JMS-17-2 hydrochloride:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

JMS-17-2 hydrochloride is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 hydrochloride impairs metastatic seeding and colonization of breast cancer cells[1].

IC50 & Target

IC50: 0.32 nM (CX3CR1)[1]

In Vivo

JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice[1].

Animal Model: SCID mice (~25g) with MDA-231 xenograft[1]
Dosage: 10 mg/kg
Administration: Aministered i.p.; twice a day for three weeks
Result: Caused a dramatic reduction of tumors in both skeleton and visceral organs.
Molecular Weight

456.41

Formula

C₂₅H₂₇Cl₂N₃O

CAS No.

2341841-07-2

SMILES

O=C1C2=CC=CN2C3=C(C=CC=C3)N1CCCN4CCC(C5=CC=C(Cl)C=C5)CC4.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

JMS-17-2OthersInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
JMS-17-2 hydrochloride
Cat. No.:
HY-123918A
Quantity:
MCE Japan Authorized Agent: