1. Cell Cycle/DNA Damage
  2. Eukaryotic Initiation Factor (eIF)
  3. CR-1-31-B

CR-1-31-B 

Cat. No.: HY-136453 Purity: 98.06% ee.: 98.30%
Handling Instructions

CR-1-31-B is a potent eIF4A RNA helicase inhibitor. CR-1-31-B blocks MUC1-C translation in response to growth factor stimulation in breast cancer cells.

For research use only. We do not sell to patients.

CR-1-31-B Chemical Structure

CR-1-31-B Chemical Structure

CAS No. : 1352914-52-3

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 726 In-stock
Estimated Time of Arrival: December 31
5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 2150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 5950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

CR-1-31-B is a potent eIF4A RNA helicase inhibitor. CR-1-31-B blocks MUC1-C translation in response to growth factor stimulation in breast cancer cells[1].

In Vitro

CR-1-31-B (100 nM; 24 hours) inhibits MUC1-C translation in MCF-10A cells[1].
CR-1-31-B (10 and 100 nM) decreases MUC1-C abundance in MDA-MB-468 breast cancer cells[1].

Western Blot Analysis[1]

Cell Line: MCF-10A cells (EGF/HRG stimulated)
Concentration: 100 nM
Incubation Time: 24 hours
Result: EGF-stimulated MCF-10A cells was associated with a dose-dependent decrease in MUC1-C abundance; Blocked HRG-induced increases in MUC1-C abundance.
Molecular Weight

507.53

Formula

C₂₈H₂₉NO₈

CAS No.

1352914-52-3

SMILES

O=C([[email protected]]([[email protected]]1C2=CC=CC=C2)[[email protected]@H](O)[[email protected]]3(O)[[email protected]@]1(C4=CC=C(OC)C=C4)OC5=CC(OC)=CC(OC)=C35)NOC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 300 mg/mL (591.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9703 mL 9.8516 mL 19.7033 mL
5 mM 0.3941 mL 1.9703 mL 3.9407 mL
10 mM 0.1970 mL 0.9852 mL 1.9703 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

CR-1-31-BEukaryotic Initiation Factor (eIF)MUC1-C oncoproteintranslationabundancegrowthfactorstimulationbreastcancercellsMCF-10AInhibitorinhibitorinhibit

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CR-1-31-B
Cat. No.:
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