2. Immunology/Inflammation
  3. CX3CR1
  4. AZD0233

AZD0233 is an orally active CX3CR1 antagonist. AZD0233 modulates the CX3CR1/CX3CL1 signaling axis via immunomodulatory effects. AZD0233 has improved physicochemical properties, metabolic stability, low toxicity and CYP inhibition. AZD0233 improves cardiac function and reduces macrophages and fibrotic scar in mice model of dilated cardiomyopathy. AZD0233 can be used for cardiovascular diseases like dilated cardiomyopathy research.

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AZD0233

AZD0233 Chemical Structure

CAS No. : 3036141-78-0

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AZD0233 Related Antibodies

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Description

AZD0233 is an orally active CX3CR1 antagonist. AZD0233 modulates the CX3CR1/CX3CL1 signaling axis via immunomodulatory effects. AZD0233 has improved physicochemical properties, metabolic stability, low toxicity and CYP inhibition. AZD0233 improves cardiac function and reduces macrophages and fibrotic scar in mice model of dilated cardiomyopathy. AZD0233 can be used for cardiovascular diseases like dilated cardiomyopathy research[1].

In Vivo

AZD0233 (100 mg/kg; p.o; 4-8 weeks) exhibits cardiac protective effects, improving cardiac function and promoting reverse remodeling in the muscle LIM protein knock-out (MLP-KO) mouse model of dilated cardiomyopathy (DCM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Muscle LIM protein knock-out (MLP-KO) mouse model of DCM[1]
Dosage: 100 mg/kg
Administration: p.o; 4 weeks or 8 weeks
Result: Showed a significant reduction in CD11b+ Ly6Chi inflammatory monocytes.
Showed a dose-dependent relative reduction in CX3CR1+ leukocytes and a decrease in myocardial fibrosis.
Revealed a reduction in abundance of CD45+ leukocytes starting at 2 weeks and lasting up to 8 weeks.
Shifted macrophage polarization towards M2 phenotype and inflammation resolution.
Clinical Trial
Molecular Weight

456.53

Formula

C19H29FN6O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=CC(F)=C(C=N1)[C@@H](CC2=NC(NS(C)(=O)=O)=NC(N[C@H](CC(C)C)CO)=N2)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (10.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1904 mL 10.9522 mL 21.9044 mL
5 mM 0.4381 mL 2.1904 mL 4.3809 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1904 mL 10.9522 mL 21.9044 mL 54.7609 mL
5 mM 0.4381 mL 2.1904 mL 4.3809 mL 10.9522 mL
10 mM 0.2190 mL 1.0952 mL 2.1904 mL 5.4761 mL
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AZD0233 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD02333036141-78-0AZD 0233AZD-0233CX3CR1CX3C chemokine receptor1GPR13fractalkine receptorAntagonistCX3CR1/CX3CL1ImmunomodulatoryDilated cardiomyopathyInhibitorinhibitorinhibit

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