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Pathways Recommended:	PI3K/Akt/mTOR
Isoforms Recommended:	Cathepsin K

Results for "

Cathepsin K

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cathepsin (43) Akt (1) Apoptosis (2) Cytochrome P450 (2) ERK (1) Filovirus (2) Interleukin Related (1) Isotope-Labeled Compounds (1) MMP (3) Nuclear Factor of activated T Cells (NFAT) (1) Parasite (3) PI3K (1) Proteasome (3) Raf (1) RANKL/RANK (1) Ras (1) Reference Standards (6) SARS-CoV (7) Ser/Thr Protease (2) Src (1) TNF Receptor (1) Virus Protease (1)
By Research Areas:	Cancer (13) Infection (6) Inflammation/Immunology (19) Metabolic Disease (20)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: Cathepsin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100223

Calpeptin Maximum Cited Publications 27 Publications Verification	Cathepsin Proteasome Apoptosis	Inflammation/Immunology
Calpeptin is a potent, cell penetrating calpain inhibitor, with an ID₅₀ of 40 nM for Calpain I in human platelets . Calpeptin is also an inhibitor of cathepsin K .

HY-10042

Odanacatib 10+ Cited Publications MK-0822	Cathepsin	Metabolic Disease Cancer
Odanacatib (MK-0822) is a potent and selective inhibitor of cathepsin K, with an IC₅₀ of 0.2 nM for human cathepsin K.

HY-119293

K777 3 Publications Verification	Cathepsin Cytochrome P450 Parasite SARS-CoV Filovirus	Infection Inflammation/Immunology Cancer
K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC₅₀ of 60 nM. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC₅₀ values of 0.68 nM and 0.87 nM, respectively .

HY-15100

Balicatib 2 Publications Verification AAE581	Cathepsin	Inflammation/Immunology
Balicatib (AAE581) is a potent, orally active and selective cathepsin K inhibitor with IC₅₀ values of 22, 61, 48, 2900 nM for cathepsin K, cathepsin B, cathepsin L, cathepsin S, respectively. Balicatib inhibits bone turnover, decreases bone formation rates. Balicatib has the potential for the research of osteoporosis .

HY-P4373A

Hepcidin-1 (mouse) TFA 1 Publications Verification	Cathepsin MMP	Inflammation/Immunology
Hepcidin-1 (mouse) TFA is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) TFA upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) TFA downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) TFA facilitates osteoclast differentiation .

HY-103352

L-006235 L-235	Cathepsin	Metabolic Disease
L-006235 (L-235) is a potent, selective, reversible and orally active inhibitor of cathepsin K, with an IC₅₀ of 5 nM in bone resorption assay. L-006235 shows selectivity for cathepsin K (K_i=0.2 nM) over cathepsin B, cathepsin L, and cathepsin S (K_i=1, 6, and 47 μM, respectively). L-006235 can reduce collagen degradation and prevent bone loss .

HY-142021

Z-Leu-Arg-AMC	Cathepsin Parasite	Infection Inflammation/Immunology
Z-Leu-Arg-AMC is a fluorogenic peptide substrate for cysteine proteases (e.g., *Cathepsin) (Ex=350 nm，Em=460 nm). Z-Leu-Arg-AMC is preferentially cleaved by Cathepsin* K and S under weakly acidic conditions, while its hydrolysis relies on residual Cathepsin S activity at neutral pH. Z-Leu-Arg-AMC serves as a substrate for recombinant Sphenophorus levis Cathepsin L, falcipain-2, falcipain-3, berghepain-2, knowlepain-2, vivapain-2, as well as falcipain-2 chimeras and constructs. It enables quantitative detection of cysteine protease activity in human inflammatory bronchoalveolar lavage fluid via fluorescence generation. Z-Leu-Arg-AMC can be used in research related to pulmonary inflammatory diseases and malaria .

HY-146584

Cathepsin C-IN-5	Cathepsin	Inflammation/Immunology
Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC₅₀s of 59.9 nM, 4.26 µM, >5 µM, >5 µM, >5 µM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity .

HY-10294

Relacatib SB-462795	Cathepsin	Metabolic Disease Cancer
Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V with K_i values of 41 pM, 68 pM, and 53 pM, respectively. Relacatib inhibits endogenous cathepsin K in situ in human osteoclasts and human osteoclast-mediated bone resorption with IC₅₀ values of 45 nM and 70 nM, respectively. Relacatib inhibits bone resorption in vitro in human tissue as well as in cynomolgus monkeys in vivo .

HY-P4217

Z-Gly-Pro-Arg-AMC hydrochloride 1 Publications Verification	Cathepsin	Others
Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. Z-Gly-Pro-Arg-AMC hydrochloride can be used to determine trypsin and cathepsin K activity .

HY-P3153

Cathepsin K 1 Publications Verification	Cathepsin	Metabolic Disease
Cathepsin K is a cysteine protease with endo and collagenolytic activities. Cathepsin K induces degradation of bone collagen and can be used for the research of osteoporosis .

HY-Y0241

2-Cyanopyrimidine	Cathepsin	Metabolic Disease
2-Cyanopyrimidine is a potent and non-selective *cysteine protease cathepsin* K inhibitor with an IC₅₀** of 170 nM. 2-Cyanopyrimidine is used for osteoporos .

HY-108044

ONO-5334	Cathepsin SARS-CoV	Metabolic Disease
ONO-5334 is a potent, selective and orally active cathepsin K inhibitor with K_i values of 0.10 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. ONO 5334 is an effective antiviral compound against SAR-COV-2 virus activity with an EC₅₀ value of 500 nM. ONO-5334 has the potential for the study of osteoporosis and COVID-19 disease .

HY-147774

Cathepsin K inhibitor 6	Cathepsin	Others
Cathepsin K inhibitor 6 (compound 19) is an inhibitor of cathepsin K (Cat K) with an IC₅₀ of 17 nM. Cathepsin K inhibitor 6 also has inhibitory effects on other isoforms, with IC₅₀s of 0.05 μM (Cat L) and 0.3 μM (Cat B), respectively .

HY-P4373

Hepcidin-1 (mouse)	Cathepsin MMP	Metabolic Disease
Hepcidin-1 (mouse) is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) facilitates osteoclast differentiation .

HY-177315

Cathepsin K-IN-8	Cathepsin	Inflammation/Immunology Cancer
Cathepsin K-IN-8 (cxample 6-60) is a cathepsin K inhibitor that can be used for the study of inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis and tumors .

HY-143714

Cathepsin K inhibitor 2	Cathepsin	Inflammation/Immunology
Cathepsin K inhibitor 2 is a potent inhibitor of cathepsin K. Cathepsin K, Cat K is a cysteine protease expressed under the control of CTSK gene and closely related to osteoporosis, whose main function is to hydrolyze collagen. Cathepsin K inhibitor 2 has the potential for the research of osteoarthfitis (extracted from patent WO2021147882A1, compound 78) .

HY-50887

L-873724	Cathepsin	Metabolic Disease
L-873724 is a potent, orally bioavailable, selective and reversible non-basic cathepsin K inhibitor, with IC₅₀s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively . L-873724 also exhibits an IC₅₀ of 0.5 nM for rabbit cathepsin K. L-873724 inhibits bone resorption .

HY-119293A

K777 tosylate	Cathepsin Cytochrome P450 Parasite SARS-CoV Filovirus	Infection Inflammation/Immunology Cancer
K777 tosylate is a potent, orally active and irreversible cysteine protease inhibitor. K777 tosylate is also a potent CYP3A4 inhibitor with an IC₅₀ of 60 nM. K777 tosylate irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 tosylate is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 tosylate inhibits SARS-CoV and EBOV pseudovirus entry with IC₅₀ values of 0.68 nM and 0.87 nM, respectively .

HY-152108

SARS-CoV-2 Mpro-IN-6	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-6 is a covalent, irreversible and selective SARS-CoV-2 M ^pro inhibitor with an IC₅₀ of 0.18 μM. SARS-CoV-2 Mpro-IN-6 does not inhibit human cathepsins B, F, K, and L, and caspase 3 .

HY-P5377

Abz-HPGGPQ-EDDnp Cathepsin K substrate	Ser/Thr Protease	Others
Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.)

HY-144813

Gü2602	Cathepsin	Inflammation/Immunology Cancer
Gü2602 is a potent, reversible cathepsin K (CatK) inhibitor with a K_i of 0.013 nM for mature CatK (mCatK). Gü2602 suppresses the autocatalytic activation of the cathepsin K zymogen .

HY-151524

Cathepsin K inhibitor 3	Cathepsin	Inflammation/Immunology
Cathepsin K inhibitor 3 (compound 23) is a highly selective cathepsin K inhibitor with an IC₅₀ value of 0.5 nM. Cathepsin K inhibitor 3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies .

HY-P10061

Cathepsin K inhibitor 4	Cathepsin	Cancer
Cathepsin K inhibitor 4 is a potent carbohydrazide Cathepsin K inhibitor with IC₅₀s of 13 nM, 269 nM, 296 nM for human, rat, mouse Cathepsin K, respectively .

HY-163842

Cathepsin K inhibitor 7	Cathepsin	Inflammation/Immunology
Cathepsin K inhibitor 7 (compound 7) is a Cathepsin K inhibitor with the pK_i of 7.3 aganist CatK. Cathepsin K inhibitor 7 can be used for study of osteoporosis .

HY-113721

BML-244	Cathepsin	Inflammation/Immunology
BML-244 is a potent cathepsin K inhibitor. BML-244 can be used in the study of rheumatoid arthritis (RA) and periodontitis .

HY-100701

Dutacatib	Cathepsin SARS-CoV Virus Protease	Infection Cancer
Dutacatib is inhibitor for SARS-CoV-2 3CL ^pro and cathepsin K, which exhibits antiviral activity and ameliorates the cancer-induced bone diseases .

HY-P10117

Cathepsin K inhibitor 5	Cathepsin	Metabolic Disease
Cathepsin K inhibitor 5 is a potent Cathepsin K inhibitor .

HY-10290

MK-0674	Cathepsin	Metabolic Disease
MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC₅₀ of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S .

HY-14360

MK 1256	Cathepsin	Metabolic Disease
MK 1256 is a highly selective and orally active inhibitor of tissue protease K (Cat K) with an IC₅₀ of 0.62 nM. MK 1256 shows extremely high selectivity towards other tissue proteases (all > 1100 times), with only a slightly lower selectivity for tissue protease F (Cat F) (110 times). MK 1256 exhibits strong anti-bone resorption activity in the osteoporosis model of rhesus monkeys with ovariectomy. MK 1256 can be used for research on osteoporosis .

HY-144812

Gü1303	Cathepsin	Inflammation/Immunology Cancer
Gü1303 is a potent, reversible, slow-binding cathepsin K (CatK) inhibitor with a K_i of 0.91 nM for mature CatK (mCatK). Gü1303 suppresses the autocatalytic activation of the cathepsin K zymogen .

HY-103352R

L-006235 (Standard) L-235 (Standard)	Reference Standards Cathepsin	Metabolic Disease
L-006235 (Standard) is the analytical standard of L-006235. This product is intended for research and analytical applications. L-006235 (L-235) is a potent, selective, reversible and orally active inhibitor of cathepsin K, with an IC50 of 5 nM in bone resorption assay. L-006235 shows selectivity for cathepsin K (Ki=0.2 nM) over cathepsin B, cathepsin L, and cathepsin S (Ki=1, 6, and 47 μM, respectively). L-006235 can reduce collagen degradation and prevent bone loss .

HY-179697

Cathepsin K-IN-9	Cathepsin	Metabolic Disease
Cathepsin K-IN-9 is a selective, potent and orally active Cathepsin K inhibitor with an IC₅₀ of 6.2 nM. Cathepsin K-IN-9 has IC₅₀ > 10000 nM for cathepsin B, L, and S, showing over 1600-fold selectivity. Cathepsin K-IN-9 has excellent safety and metabolic stability.Cathepsin K-IN-9 can be used for the research of osteoporosis .

HY-10042S

Odanacatib-d4 MK-0822-d₄	Isotope-Labeled Compounds	Metabolic Disease Cancer
Odanacatib-d4 is the deuterium labeled Odanacatib (HY-10042). Odanacatib is a potent and selective inhibitor of cathepsin K, with an IC₅₀ of 0.2 nM for human cathepsin K .

HY-149926

Cathepsin Inhibitor 3	Ser/Thr Protease	Others
Cathepsin Inhibitor 3 (Compound 53k) is a non-radioactive intermediate in compound [ ¹⁸F] 2k radioactive synthesis, which has selectivity for cathepsin S. Cathepsin Inhibitor 3 can undergo radioactive fluorination and can be used for fluorine-18 labeling research . Cathepsin Inhibitor 3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-139685

ABP 25	Cathepsin	Others
ABP 25 is an activity-based probe for cathepsin K imaging with excellent potency and selectivity.

HY-15099

NC 2300 VEL 0230	Cathepsin	Inflammation/Immunology
NC 2300 (VEL-0230)is a selective and orally active cysteine cathepsin inhibitor with the IC₅₀ values of 284, 34.5, and 186 nM for cathepsin B, K, and S, respectively.NC 2300 can be used for study of diseases involving bone mineral disorders .

HY-100223R

Calpeptin (Standard)	Reference Standards Cathepsin Proteasome Apoptosis	Inflammation/Immunology
Calpeptin (Standard) is the analytical standard of Calpeptin. This product is intended for research and analytical applications. Calpeptin is a potent, cell penetrating calpain inhibitor, with an ID50 of 40 nM for Calpain I in human platelets . Calpeptin is also an inhibitor of cathepsin K .

HY-15101

MV061194	Cathepsin	Metabolic Disease
MV061194 is a selective cathepsin K inhibitor with a human K_i of 2.5 nM. MV061194 can be used for the research of osteoporosis .

HY-Y0241R

2-Cyanopyrimidine (Standard)	Reference Standards Cathepsin	Metabolic Disease
2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos .

HY-10042R

Odanacatib (Standard) MK-0822 (Standard)	Cathepsin Reference Standards	Metabolic Disease Cancer
Odanacatib (Standard) is the analytical standard of Odanacatib (HY-10042). This product is intended for research and analytical applications. Odanacatib (MK-0822) is a potent and selective inhibitor of cathepsin K, with an IC50 of 0.2 nM for human cathepsin K.

HY-181741

PI3K-001	Cathepsin	Inflammation/Immunology
PI3K-001 is a cathepsin B-responsive prodrug and antifibrotic agent. PI3K-001 undergoes cathepsin B-mediated cleavage of the Val-Ala linker in fibrotic lung lesions to release an active *PI3K* inhibitor payload, while it remains stable in healthy tissues. PI3K-001 improves collagen deposition, tissue collapse and alveolar injury in fibrotic lung tissues. PI3K-001 is applicable for the research of pulmonary fibrosis .

HY-108044R

ONO-5334 (Standard)	Reference Standards Cathepsin SARS-CoV	Metabolic Disease
ONO-5334 (Standard) is the analytical standard of ONO-5334 (HY-108044). This product is intended for research and analytical applications. ONO-5334 is a potent, selective and orally active cathepsin K inhibitor with K_i values of 0.10 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. ONO 5334 is an effective antiviral compound against SAR-COV-2 virus activity with an EC₅₀ value of 500 nM. ONO-5334 has the potential for the study of osteoporosis and COVID-19 disease .

HY-10294R

Relacatib (Standard) SB-462795 (Standard)	Reference Standards Cathepsin	Metabolic Disease Cancer
Relacatib (Standard) is the analytical standard of Relacatib (HY-10294). This product is intended for research and analytical applications. Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V with K_i values of 41 pM, 68 pM, and 53 pM, respectively. Relacatib inhibits endogenous cathepsin K in situ in human osteoclasts and human osteoclast-mediated bone resorption with IC₅₀ values of 45 nM and 70 nM, respectively. Relacatib inhibits bone resorption in vitro in human tissue as well as in cynomolgus monkeys in vivo .

HY-181513

DPP-1-IN-2	Interleukin Related TNF Receptor	Inflammation/Immunology
DPP-1-IN-2 is a DPP-I inhibitor with a human IC₅₀ of 36.8 nM and oral efficacy. DPP-1-IN-2 binds to intracellular DPP-I, increases its thermal stability, and reduces the activity and expression levels of downstream neutrophil serine proteases by inhibiting its enzymatic activity. DPP-1-IN-2 regulates the secretion of inflammatory factors and chemokines to exert anti-inflammatory effects. DPP-1-IN-2 reverses joint inflammation and tissue damage in adjuvant-induced arthritis rat models. DPP-1-IN-2 is applicable to research related to arthritis .

HY-182614

BJ-2302	Src Cathepsin PI3K Akt Ras Raf ERK MMP	Cancer
BJ-2302 is a Src kinase inhibitor with an IC₅₀ of 3.23 μM, and inhibits cathepsin S (CTSS) activity .BJ-2302 binds to Src, suppresses *PI3K/AKT* and Ras/Raf/ERK pathways, and reduces CTSS and MMP-9 expression .BJ-2302 inhibits cancer cell invasion, metastasis, proliferation, and tumor growth .BJ-2302 does not induce cytotoxicity in normal breast epithelial cells .BJ-2302 can be used for the research of breast cancer and triple-negative breast cancer .

HY-182757

Y1693	RANKL/RANK Nuclear Factor of activated T Cells (NFAT) Cathepsin	Metabolic Disease Inflammation/Immunology
Y1693 is an orally active RANKL inhibitor with a K_d of 5.03 μM for hRANKL. Y1693 inhibits the activation of the downstream c-fos/NFATc1 signaling pathway by blocking its interaction with RANK. Y1693 significantly inhibits RANKL-induced osteoclast differentiation, F-actin ring formation and bone resorptive activity, while downregulating the mRNA and protein expressions of TRAP, cathepsin K, c-fos and NFATc1. Y1693 shows no obvious cytotoxicity to bone marrow-derived macrophages and osteoclast precursor cells, and exhibits favorable ADME properties. Y1693 improves ovariectomy-induced osteoporosis in mice and reverses ligation-induced periodontal alveolar bone loss. Y1693 is applicable to research related to osteoporosis and periodontal diseases .

HY-179612

SARS-CoV-2 3CLpro-IN-34	SARS-CoV Cathepsin Proteasome	Infection
SARS-CoV-2 3CLpro-IN-34 (Compound 55) is a highly efficient non-covalent inhibitor of the SARS-CoV-2 3CL ^pro protease (b. SARS-CoV-2 3CL ^pro protease) with an IC₅₀ of 1.9 μM. SARS-CoV-2 3CLpro-IN-34 can inhibit the 3CL ^pro protein of SARS-CoV-1, with its IC₅₀ being 3.2 μM, and it shows high selectivity towards host cysteine proteases (such as **cathepsins L/K and calpain). SARS-CoV-2 3CLpro-IN-34 exhibits antiviral activity in cells infected with SARS-CoV-2, with its EC₅₀** being 25 μM, and it is not affected by P-gp inhibitors and shows no significant cytotoxicity. SARS-CoV-2 3CLpro-IN-34 can be used for research on SARS-CoV-2 infection .

Cat. No.	Product Name	Target	Research Area

HY-P4373A

Hepcidin-1 (mouse) TFA 1 Publications Verification	Cathepsin MMP	Inflammation/Immunology
Hepcidin-1 (mouse) TFA is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) TFA upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) TFA downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) TFA facilitates osteoclast differentiation .

HY-P4217

Z-Gly-Pro-Arg-AMC hydrochloride 1 Publications Verification	Cathepsin	Others
Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. Z-Gly-Pro-Arg-AMC hydrochloride can be used to determine trypsin and cathepsin K activity .

HY-P4373

Hepcidin-1 (mouse)	Cathepsin MMP	Metabolic Disease
Hepcidin-1 (mouse) is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) facilitates osteoclast differentiation .

HY-P5377

Abz-HPGGPQ-EDDnp Cathepsin K substrate	Ser/Thr Protease	Others
Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.)

HY-P10061

Cathepsin K inhibitor 4	Cathepsin	Cancer
Cathepsin K inhibitor 4 is a potent carbohydrazide Cathepsin K inhibitor with IC₅₀s of 13 nM, 269 nM, 296 nM for human, rat, mouse Cathepsin K, respectively .

HY-P10117

Cathepsin K inhibitor 5	Cathepsin	Metabolic Disease
Cathepsin K inhibitor 5 is a potent Cathepsin K inhibitor .

Recombinant Proteins Recommended:

Cathepsin K

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72158

	Cathepsin K Protein, Rat (His) Ctsk; Cathepsin K; EC 3.4.22.38	Rat	E. coli
	Cathepsin K protein is a thiol protease that is essential for osteoclastic bone resorption and regulation of bone remodeling. It exhibits potent endoprotease activity against fibrinogen under acidic conditions, suggesting its role in extracellular matrix degradation. Cathepsin K Protein, Rat (His) is the recombinant rat-derived Cathepsin K protein, expressed by E. coli , with N-6*His labeled tag.

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Source
Tag
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Gene ID
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Host:	Rabbit (3)
Reactivity:	Human (2) Mouse (2) Rat (2)
Application:	IHC-P (3) ICC/IF (2) IF-Tissue (1) IHC-F (2) WB (2) FC (1) ELISA (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Polyclonal (1) Monoclonal (2) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81163

	Cathepsin K Antibody 1 Publications Verification Cathepsin K; ProCathepsin K; Cathepsin K precursor; Cathepsin O; Cathepsin O1; Cathepsin O2; Cathepsin X; CathepsinK; CTS02; CTSK; CTSK protein; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD; Pycnodysostosis; cath-K; CK.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Rat
	Cathepsin K Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Cathepsin K.

HY-P82802

	Cathepsin L/V/K/H Antibody (YA2547) Cathepsin; CTSL; CTSV; CTSK; CTSH	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Cathepsin L/V/K/H Antibody (YA2547) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cathepsin L/V/K/H.

HY-P86837

	Cathepsin L/V/K/H Antibody (YA6530) Cathepsin L antibody; Cathepsin L 1 b antibody; Cathepsin L1 antibody; Cathepsin L1 light chain antibody; CathepsinL antibody; CATL antibody; CATL1_HUMAN antibody; cb15 antibody; CTSL antibody; Cathepsin L antibody; Cathepsin L 1 b antibody; Cathepsin L1 antibody; Cathepsin L1 light chain antibody; CathepsinL antibody; CATL antibody; CATL1_HUMAN antibody; cb15 antibody; CTSL antibody; CTSL1 antibody; ctsl1b antibody; FLJ31037 antibody; hgg1 antibody; Major excreted protein antibody; MEP antibody; MGC123162 antibody; wu:fb30g09 antibody;	IHC-P, IHC-F, IF-Tissue	Human, Mouse
	Cathepsin L/V/K/H Antibody (YA6530) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cathepsin L/V/K/H.

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HY-149926

Cathepsin Inhibitor 3		Alkynes
Cathepsin Inhibitor 3 (Compound 53k) is a non-radioactive intermediate in compound [ ¹⁸F] 2k radioactive synthesis, which has selectivity for cathepsin S. Cathepsin Inhibitor 3 can undergo radioactive fluorination and can be used for fluorine-18 labeling research . Cathepsin Inhibitor 3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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