SARS-CoV-2 Mpro-IN-6
SARS-CoV-2 Mpro-IN-6 is a covalent, irreversible and selective SARS-CoV-2 Mpro inhibitor with an IC50 of 0.18 μM. SARS-CoV-2 Mpro-IN-6 does not inhibit human cathepsins B, F, K, and L, and caspase 3.
For research use only. We do not sell to patients.
- CAS No.: 2768834-48-4
- Formula: C18H18Cl3N3O2S
- Molecular Weight:446.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.18 μM (SARS-CoV-2 Mpro)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | CC50 |
12.5 μM
Compound: GD-9
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Cytotoxicity against african green monkey Vero E6 cells assessed as reduction in cell viability after 26 hrs by MTS assay
Cytotoxicity against african green monkey Vero E6 cells assessed as reduction in cell viability after 26 hrs by MTS assay
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[PMID: 36475694] |
| Vero C1008 | EC50 |
2.64 μM
Compound: 81
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Antiviral activity against MERS-CoV infected in Vero E6 cells assessed as reduction in viral replication measured after 48 hrs by qRT-PCR assay
Antiviral activity against MERS-CoV infected in Vero E6 cells assessed as reduction in viral replication measured after 48 hrs by qRT-PCR assay
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[PMID: 37244162] |
| Vero C1008 | EC50 |
2.64 μM
Compound: 81
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Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as reduction in viral replication
Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as reduction in viral replication
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[PMID: 37244162] |
SARS-CoV-2 Mpro-IN-6 (GD-9) shows good antiviral potency against SARS-CoV-2 (ECsub>50= 2.64 μM). SARS-CoV-2 Mpro-IN-6 displays some cytotoxicity (CCsub>50of 12.51 μM) in Vero E6 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2768834-48-4
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Molecular Weight 446.78
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Formula C18H18Cl3N3O2S
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SMILES
O=C([C@H]1N(C2=CC=C(Cl)C(Cl)=C2)CCN(C(CCl)=O)C1)NCC3=CC=CS3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SARS-CoV-2 Mpro-IN-6 Related Classifications
HY-152108 Related Classifications
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