Gü1303
Gü1303 is a potent, reversible, slow-binding cathepsin K (CatK) inhibitor with a Ki of 0.91 nM for mature CatK (mCatK). Gü1303 suppresses the autocatalytic activation of the cathepsin K zymogen.
For research use only. We do not sell to patients.
- CAS No.: 1043922-53-7
- Formula: C20H22N4O3
- Molecular Weight:366.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Cathepsin Isoforms
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Biological Activity
Ki: 0.91 nM (mCatK)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LLC-MK2 | CC50 |
42 μM
Compound: Neq0677
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Cytotoxicity against monkey LLC-MK2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against monkey LLC-MK2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 34095840] |
| U2OS | CC50 |
10.2 μM
Compound: Neq0677
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Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 34095840] |
Chemical Information
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CAS No. 1043922-53-7
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Molecular Weight 366.41
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Formula C20H22N4O3
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SMILES
CN(N(C([C@@H](NC(OCC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O)C)C#N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Gü1303 Related Classifications
HY-144812 Related Classifications
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