Hepcidin-1 (mouse)
Based on 2 publication(s) in Google Scholar
Hepcidin-1 (mouse) is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) facilitates osteoclast differentiation.
For research use only. We do not sell to patients.
- CAS No.: 1676104-75-8
- Formula: C111H169N31O35S8
- Molecular Weight:2754.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Hepcidin-1 (mouse)
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Biological Activity
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MMP-9 |
cathepsin K |
Hepcidin-1 mouse (200-800 nM, 4 days) facilitates RANKL (50 ng/mL)-induced differentiation of raw264.7 cells[1].
Hepcidin-1 mouse (0-800 nM, 4 days) up-regulates the expression of TRAP, CTK, and MMP-9 mRNA[1].
Hepcidin-1 mouse (0-800 nM, 20 h) increases the Level of Trap-5b protein and decreased Ferroportin 1 (FPN1) protein in RAW264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 cells
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Concentration:0, 200, 400, or 800 nM
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Incubation Time:20 h
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Result:Decreased Ferroportin 1 (FPN1) protein.
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Cell Line:RAW264.7 cells
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Concentration:0, 200, 400, or 800 nM
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Incubation Time:4 days
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Result:Increased the gene expression of TRAP, CTK, and MMP-9 in a dose-dependent manner.
Chemical Information
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CAS No. 1676104-75-8
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Molecular Weight 2754.24
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Formula C111H169N31O35S8
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Sequence
Asp-Thr-Asn-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Lys-Cys-Cys-Asn-Asn-Ser-Gln-Cys-Gly-Ile-Cys-Cys-Lys-Thr (Disulfide bridge: Cys7-Cys23,Cys10-Cys22,Cys11-Cys19,Cys13-Cys14)
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Sequence Shortening
DTNFPICIFCCKCCNNSQCGICCKT (Disulfide bridge: Cys7-Cys23,Cys10-Cys22,Cys11-Cys19,Cys13-Cys14)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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J Neurooncol
Tumor-associated macrophages promote ferroptosis resistance in glioblastoma by stimulating iron-loaded extracellular vesicle release. [Abstract]2026 Apr 13;177(2):99. PMID: 41973350 -
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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