Cathepsin K inhibitor 3
Cathepsin K inhibitor 3 (compound 23) is a highly selective cathepsin K inhibitor with an IC50 value of 0.5 nM. Cathepsin K inhibitor 3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies.
For research use only. We do not sell to patients.
- CAS No.: 1694638-70-4
- Formula: C30H31FN4O4S
- Molecular Weight:562.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Cathepsin Isoforms
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Biological Activity
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cathepsin K 0.5 nM (IC50) |
The pharmacokinetic parameters of compound 23
| Parameters | Cl(mL/min/kg) | T1/2(h) | %F |
| Rat | 13 | 1 | 33 |
| Dog | 3.1 | 4.1 | 38 |
| Rhesus | 18.5 | 2.3 | 55 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1694638-70-4
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Molecular Weight 562.65
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Formula C30H31FN4O4S
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SMILES
O=S1(CCN(CC1)C2=CC=C(C3=C([C@@H]4CCCC[C@H]4C(NC5(CC5)C#N)=O)OC(C6=CC=C(C=C6)F)=N3)C=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cathepsin K inhibitor 3 Related Classifications
HY-151524 Related Classifications
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