Cathepsin K Antibody

Cat. No.: HY-P81163: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

Cathepsin K Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Cathepsin K.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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Cathepsin K Antibody Featured Recommendations:

1 Publications Citing Use of MCE Cathepsin K Antibody

•J Transl Med. 2025 Jan 31;23(1):142. [Abstract]

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Verification Image
Background
Documentation

Description

Cathepsin K Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Cathepsin K.

Host

Rabbit

Clonality

Polyclonal

Molecular Weight

Predicted band size: 36 kDa;

Observed band size: 46 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Rat Predicted Reactivity: Human, Mouse, Dog, Pig, Cow, Horse, GuineaPig

Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.

SwissProt ID

P43235

Gene ID

1513 [NCBI]

Immunogen

KLH conjugated synthetic peptide derived from human Cathepsin K: 112-210/329

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-2000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:5000-10000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-500
IHC-F IHC-F: Immunohistochemistry-Frozen	1:100-500
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-500

Sensitivity	Endogenous	Purity	affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Verification Image

Western blot analysis of extracts from Heart (lane 1) and Muscle (lane 2) using Cathepsin K antibody. Proteins were transferred to a PVDF membrane and blocked with 5% nonfat powdered milk in PBST for 2 hour at room temperature. The primary antibody (1/2000) and Loading control antibody (GAPDH, 1/3000) was diluted with 5% nonfat powdered milk in PBST at 4°C overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (1/8,000) was incubated for 45min at room temperature.

Background

Function：Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042)

Subcellular Localization：Lysosome; Secreted; Apical cell membrane; Peripheral membrane protein; Extracellular side

Expression：
Tissue_specificity:It is primarily expressed in osteoclasts (skeletal tissue) (PubMed:7805878) . It is also expressed in thyroid epithelial cells (PubMed:11082042) .

RRID

AB_3103080

Database

Entrez Gene: 29175 Rat

SwissProt: O35186 Rat

Synonyms

Cathepsin K; Procathepsin K; Cathepsin K precursor; Cathepsin O; Cathepsin O1; Cathepsin O2; Cathepsin X; CathepsinK; CTS02; CTSK; CTSK protein; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD; Pycnodysostosis; cath-K; CK.

Documentation

Select Batch:

Data Sheet (234 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

Cathepsin K Antibody Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Cathepsin K Antibody

Cathepsin K Antibody Featured Recommendations:

1 Publications Citing Use of MCE Cathepsin K Antibody

Product Detail

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Background

Documentation

Cathepsin K Antibody Related Classifications

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