CTSK - cathepsin K Gene

Also Known as CTSO; PKND; PYCD; CTS02; CTSO1; CTSO2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1513

About CTSK

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:150,796,208-150,808,260 (from NCBI)

This gene has 20 transcripts (splice variants), 240 orthologues, 12 paralogues and is associated with 3 phenotypes. Broad expression in gall bladder (RPKM 190.4), urinary bladder (RPKM 132.0) and 15 other tissues.

Summary

The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]

CTSK Products (1)

mRNA	Protein	Name
NM_000396.4	NP_000387.1	cathepsin K preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables collagen binding	IDA IDA: Inferred from direct assay	22952693	GOA
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	22952693	GOA
enables cysteine-type peptidase activity	IDA IDA: Inferred from direct assay	19834056	GOA
enables fibronectin binding	IPI IPI: Inferred from physical interaction	22952693	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12504904	GOA
enables proteoglycan binding	IPI IPI: Inferred from physical interaction	22952693	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within collagen catabolic process	IDA IDA: Inferred from direct assay	19834056	GOA
involved in collagen catabolic process	IDA IDA: Inferred from direct assay	22952693	GOA
involved in proteolysis involved in protein catabolic process	IDA IDA: Inferred from direct assay	11082042	GOA
involved in thyroid hormone generation	IDA IDA: Inferred from direct assay	11082042	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	11082042	GOA
located in lysosome	IDA IDA: Inferred from direct assay	11082042	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTSK Protein Structure

Inhibitor_I29

Peptidase_C1

0
100
200
300
329 a.a.

Protein Preferred Names	Protein Names
cathepsin K	cathepsin O cathepsin O1 cathepsin O2 cathepsin X

CTSK Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81163	Cathepsin K Antibody	WB, ELISA, IHC-P, IHC-F, ICC/IF	Rat
HY-P82802	Cathepsin L/V/K/H Antibody (YA2547)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Osteopetrosis	Albers-Schonberg Disease Marble Bone Disease Osteopetroses Marble Bones Osteopetrosis And Related Disorders Congenital Osteopetrosis Marble Bone Albers-Schoenberg Disease Albers-Schonberg Osteopetrosis Osteosclerosis Fragilis Ivory Bones
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Brittle Bone Disorder	Osteogenesis Imperfecta Brittle Bone Disease Fragilitas Ossium Osteopsathyrosis Lobstein Disease Oi Vrolik Disease Lobstein'S Disease Lobstein'S Syndrome Vrolik'S Disease Porak And Durante Disease Glass Bone Disease Osteogenesis Imperfecta, Dominant Perinatal Lethal Osteogenesis Imperfecta, Recessive Perinatal Lethal Brittle Bone Syndrome Oi - [Osteogenesis Imperfecta] Ossium Fragility Osteitis Fragilitans Bony Fragility Blue Sclera With Fragility Of Bone And Deafness White Blue Sclera - Fragility Of Bone - Deafness
Osteochondrodysplasia	Chondrodystrophy Skeletal Dysplasia Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv
Bone Benign Neoplasm
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Ischemic Bone Disease
Hypercementosis	Cementation Hyperplasia
Localized Scleroderma	Morphea Localised Scleroderma Localized Fibrosing Scleroderma Circumscribed Scleroderma Localised Morphea Localised Morphoea Localized Morphea Scleroderma, Circumscribed Or Localised Scleroderma, Circumscribed Or Localized Scleroderma, Localized
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Metachondromatosis	METCDS MC
Van Buchem Disease	Hyperostosis Corticalis Generalisata Hyperphosphatasemia Tarda VBCH Sost-Related Sclerosing Bone Dysplasia Endosteal Hyperostosis Autosomal Recessive Sclerosteosis Endosteal Hyperostosis, Autosomal Recessive Hyperotosis Corticalis Generalisata Familiaris Sost Sclerosing Bone Dysplasia Smith-Lemli-Opitz Syndrome
Uterus Perivascular Epithelioid Cell Tumor	Uterine Corpus Pecoma
Osteopetrosis, Autosomal Dominant 2	OPTA2 Autosomal Dominant Osteopetrosis 2 Osteopetrosis Autosomal Dominant Type 2 Osteopetrosis, Autosomal Dominant, Type Ii Albers-Schonberg Osteopetrosis Autosomal Dominant Albers-Schonberg Disease Osteopetrosis Marble Bones, Autosomal Dominant Osteosclerosis Fragilis Generalisata Albers-Schonberg Disease, Autosomal Dominant Autosomal Dominant Osteopetrosis Type Ii Albers-Schönberg Osteopetrosis Autosomal Dominant Osteopetrosis Type 2 Marble Disease Autosomal Dominant Osteopetrosis, Autosomal Dominant, Type 2
Perivascular Tumor	Malignant Perivascular Cancer
Glucocorticoid-Induced Osteoporosis	Steroid-Induced Osteoporosis
Scoliosis
Alveolar Soft Part Sarcoma	ASPS Alveolar Soft-Part Sarcoma Sarcoma, Alveolar Soft Part Alveolar Soft Tissue Sarcoma Sarcoma Alveolar Soft Part Adult Alveolar Soft-Part Sarcoma Childhood Alveolar Soft-Part Sarcoma
Primary Bone Dysplasia	Primary Osteodysplasia Primary Skeletal Dysplasia
Monckeberg Arteriosclerosis	Monckeberg Medial Calcific Sclerosis
Bone Development Disease
Osteoarthritis	Osteoarthrosis Degenerative Joint Disease Hypertrophic Arthritis Arthropathy Degenerative Polyarthritis Degenerative Arthritis Osteoarthrosis And Allied Disorder Arthritis, Degenerative Oa Osteoarthritis Deformans Osteoarthrosis Deformans Kashin-Beck Disease
Periapical Periodontitis	Apical Periodontitis Periodontitis Apical
Mammary Paget'S Disease	Paget'S Disease Mammary Paget Disease Paget'S Disease Of The Breast Paget Disease Of The Breast Paget'S Disease Of The Nipple Paget'S Disease, Mammary Paget Cell Neoplasm Paget Disease Of The Nipple Pagets Disease Mammary Osteitis Deformans
Nail Disorder, Nonsyndromic Congenital, 9	Nail Dysplasia NDNC9 Anonychia-Onycholysis, Isolated Onychodystrophy Nonsyndromic Congenital Nail Disorder 9 Dystrophia Unguium
Lymphangioleiomyomatosis	Lymphangiomyomatosis LAM Lung Lymphangioleiomyomatosis Pulmonary Lymphangioleiomyomatosis Lymphangioleiomyomatosis, Somatic Lymphangio-Myomatosis
Autosomal Recessive Disease	Autosomal Recessive Disorder
Endosteal Hyperostosis, Autosomal Dominant	Osteosclerosis Worth Syndrome Osteosclerosis, Autosomal Dominant Hyperostosis, Endosteal Endosteal Hyperostosis, Worth Type Worth Disease Autosomal Dominant Osteosclerosis, Worth Type Hyperostosis Corticalis Generalisata, Benign Form Of Worth, With Torus Palatinus Autosomal Dominant Endosteal Hyperostosis Autosomal Dominant Osteosclerosis Benign Form Of Worth Hyperostosis Corticalis Generalisata With Torus Platinus Worth'S Syndrome Worth Type Autosomal Dominant Osteosclerosis Hyperostosis Corticalis Generalisata, Benign Form Of Worth With Torus Palatinus Osteosclerosis, Autosomal Dominant, Worth Type WENHY Endosteal Hyperostosis Autosomal Dominant Hyperostosis Corticalis Generalisata Benign Form Of Worth With Torus Palatinus Osteosclerosis Autosomal Dominant Acquired Osteosclerosis
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Gum Cancer	Malignant Neoplasm Of Gum Malignant Tumor Of Gum Malignant Gingival Tumor Malignant Neoplasm Of Other Sites Of Gum Malignant Tumour Of Gingiva
Bone Resorption Disease	Bone Resorption
Epithelioid Type Angiomyolipoma	Epithelioid Angiomyolipoma
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Pycnodysostosis	Pyknodysostosis PKND Pycd Toulouse-Lautrec Syndrome
Bone Remodeling Disease
Osteomyelitis
Sclerosteosis	Cortical Hyperostosis With Syndactyly Sost Cortical Hyperostosis-Syndactyly Syndrome
Perivascular Epithelioid Cell Tumor	Pecoma Perivascular Epithelioid Cell Neoplasms Neoplasm With Perivascular Epithelioid Cell Differentiation
Bone Giant Cell Tumor	Giant Cell Tumor Of Bone Osteoclastoma Gct Of Bone Bone Giant Cell Tumour Giant Cell Myeloma Giant Cell Neoplasm Of Bone Giant Cell Tumour Of Bone
Benign Giant Cell Tumor	Giant Cell Tumors
Paget'S Disease Of Bone	Osteitis Deformans Paget Disease Of Bone Osseous Paget'S Disease Paget Disease Of Bone, Familial Bone Paget Disease Familial Paget'S Disease Of Bone Paget'S Bone Disease Familial Paget Disease Of Bone Paget Disease, Bone Pdb Pagets Bone Disease
Osteoporosis, Juvenile	Idiopathic Juvenile Osteoporosis Idiopathic Osteoporosis Juvenile Osteoporosis Ijo
Periodontitis	Chronic Pericementitis Chronic Periodontitis
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Osteopetrosis, Autosomal Recessive 2	OPTB2 Autosomal Recessive Osteopetrosis 2 Osteopetrosis, Mild Autosomal Recessive Form Osteoclast-Poor Osteopetrosis Osteopetrosis, Osteoclast-Poor Mild Autosomal Recessive Form Osteopetrosis Osteopetrosis Autosomal Recessive 2 Autosomal Recessive Osteopetrosis Type 2 Osteopetrosis Osteoclast-Poor Osteopetrosis, Autosomal Recessive, Type 2
Spondylolysis	Acquired Spondylolysis
Familial Expansile Osteolysis	FEO Mccabe Disease Osteolysis, Familial Expansile Polyostotic Osteolytic Dysplasia, Hereditary Expansile Hepod Expansile Osteolysis, Familial Eof Hereditary Expansile Polyostotic Osteolytic Dysplasia
Cleidocranial Dysplasia	Cleidocranial Dysostosis CLCD Cleidocranial Dysplasia, Forme Fruste, Dental Anomalies Only Cleidocranial Dysplasia, Forme Fruste, With Brachydactyly CCD Marie-Sainton Disease Dysplasia Cleidocranial Dento-Osseous Dysplasia Marie-Sainton Syndrome Dysplasia, Cleidocranial
Tooth Resorption

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117200	Necrostatin-7	Inhibitor	99.64%	Unkown
HY-143714	Cathepsin K inhibitor 2	Inhibitor	/	Unkown
HY-155960	SH491	Inhibitor	/	Unkown
HY-182818	SH494		/	Unkown
HY-RS03337	CTSK Human Pre-designed siRNA Set A		/	Unkown
HY-RS03338	Ctsk Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS03339	Ctsk Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CTSK	VGNC	VGNC:39714
Bos taurus	CTSK	VGNC	VGNC:27817
Mus musculus	CTSK	MGD	MGI:107823
Rattus norvegicus	CTSK	RGD	RGD:61810
Felis catus	CTSK	VGNC	VGNC:61269
Macaca mulatta	CTSK	VGNC	VGNC:71559
Others	CTSK	NCBI