2-Cyanopyrimidine
Based on 1 Customer Validation
2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.92%
- CAS. Nr.: 14080-23-0
- Formel: C5H3N3
- Molecular Weight:105.10
-
Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle Cathepsin Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Beschreibung
IC50 & Target
|
cathepsin K |
In Vitro
2-Cyanopyrimidine is a 2-cyano-4-cyclohexylamino-pyrimidine derivative. Cathepsin K is a lysosomal cysteine protease[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 14080-23-0
-
Appearance Solid
-
Molecular Weight 105.10
-
Formel C5H3N3
-
Color Off-white to light yellow
-
SMILES
N#CC1=NC=CC=N1
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
H2O : 25 mg/mL (237.87 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 5 mg/mL (47.57 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Reinheit & Dokumentation
-
Data Sheet (272 KB)
-
SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
-
Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 9.5147 mL | 47.5737 mL | 95.1475 mL | 237.8687 mL |
| 5 mM | 1.9029 mL | 9.5147 mL | 19.0295 mL | 47.5737 mL | |
| 10 mM | 0.9515 mL | 4.7574 mL | 9.5147 mL | 23.7869 mL | |
| 15 mM | 0.6343 mL | 3.1716 mL | 6.3432 mL | 15.8579 mL | |
| 20 mM | 0.4757 mL | 2.3787 mL | 4.7574 mL | 11.8934 mL | |
| 25 mM | 0.3806 mL | 1.9029 mL | 3.8059 mL | 9.5147 mL | |
| 30 mM | 0.3172 mL | 1.5858 mL | 3.1716 mL | 7.9290 mL | |
| 40 mM | 0.2379 mL | 1.1893 mL | 2.3787 mL | 5.9467 mL | |
| 50 mM | 0.1903 mL | 0.9515 mL | 1.9029 mL | 4.7574 mL | |
| 60 mM | 0.1586 mL | 0.7929 mL | 1.5858 mL | 3.9645 mL | |
| 80 mM | 0.1189 mL | 0.5947 mL | 1.1893 mL | 2.9734 mL | |
| 100 mM | 0.0951 mL | 0.4757 mL | 0.9515 mL | 2.3787 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
2-Cyanopyrimidine Related Classifications
HY-Y0241 Related Classifications
Powered by Bioz