2-Cyanopyrimidine

Name: 2-Cyanopyrimidine
Brand: MedChemExpress
SKU: HY-Y0241
Rating: 4.5 (1 reviews)

Cat. No.: HY-Y0241 Purity: 99.92%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC₅₀ of 170 nM. 2-Cyanopyrimidine is used for osteoporos.

For research use only. We do not sell to patients.

2-Cyanopyrimidine Chemical Structure

CAS No. : 14080-23-0

Size	Price	Stock	Quantity
1 g	USD 25	In-stock	Estimated Time of Arrival: December 31
5 g	USD 65	In-stock	Estimated Time of Arrival: December 31
10 g		Get quote
50 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Cathepsin Isoform Specific Products:

View All Isoforms

Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

Biological Activity
Purity & Documentation
References
Customer Review

Description

2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC₅₀ of 170 nM. 2-Cyanopyrimidine is used for osteoporos^[1].

IC₅₀ & Target

IC50: 170 nM (cysteine protease cathepsin K)^[1]

In Vitro

2-Cyanopyrimidine is a 2-cyano-4-cyclohexylamino-pyrimidine derivative. Cathepsin K is a lysosomal cysteine protease^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

105.10

Formula

C₅H₃N₃

CAS No.

14080-23-0

Appearance

Solid

Color

Off-white to light yellow

SMILES

N#CC1=NC=CC=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (237.87 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	9.5147 mL	47.5737 mL	95.1475 mL
5 mM	1.9029 mL	9.5147 mL	19.0295 mL
10 mM	0.9515 mL	4.7574 mL	9.5147 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 5 mg/mL (47.57 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (272 KB) SDS (415 KB)

COA (249 KB) GC (254 KB)

Handling Instructions (2659 KB)

References

[1]. Altmann E, et al. 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem. 2007 Feb 22;50(4):591-4. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	9.5147 mL	47.5737 mL	95.1475 mL	237.8687 mL
	5 mM	1.9029 mL	9.5147 mL	19.0295 mL	47.5737 mL
	10 mM	0.9515 mL	4.7574 mL	9.5147 mL	23.7869 mL
	15 mM	0.6343 mL	3.1716 mL	6.3432 mL	15.8579 mL
	20 mM	0.4757 mL	2.3787 mL	4.7574 mL	11.8934 mL
	25 mM	0.3806 mL	1.9029 mL	3.8059 mL	9.5147 mL
	30 mM	0.3172 mL	1.5858 mL	3.1716 mL	7.9290 mL
	40 mM	0.2379 mL	1.1893 mL	2.3787 mL	5.9467 mL
	50 mM	0.1903 mL	0.9515 mL	1.9029 mL	4.7574 mL
	60 mM	0.1586 mL	0.7929 mL	1.5858 mL	3.9645 mL
	80 mM	0.1189 mL	0.5947 mL	1.1893 mL	2.9734 mL
	100 mM	0.0951 mL	0.4757 mL	0.9515 mL	2.3787 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.