2-Cyanopyrimidine
Based on 1 Customer Validation
2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.92%
- CAS 番号: 14080-23-0
- 分子式: C5H3N3
- 分子量:105.10
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Cathepsin アイソフォーム固有の製品をすべて表示
More
生物活性
製品説明
IC50 & Target
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cathepsin K |
体外実験
2-Cyanopyrimidine is a 2-cyano-4-cyclohexylamino-pyrimidine derivative. Cathepsin K is a lysosomal cysteine protease[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 14080-23-0
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性状 Solid
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分子量 105.10
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分子式 C5H3N3
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Color Off-white to light yellow
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SMILES
N#CC1=NC=CC=N1
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別名
2-ピリミジンカルボニトリル
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
H2O : 25 mg/mL (237.87 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 5 mg/mL (47.57 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
プロトコル
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
純度とドキュメンテーション
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データシート (272 KB)
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SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 9.5147 mL | 47.5737 mL | 95.1475 mL | 237.8687 mL |
| 5 mM | 1.9029 mL | 9.5147 mL | 19.0295 mL | 47.5737 mL | |
| 10 mM | 0.9515 mL | 4.7574 mL | 9.5147 mL | 23.7869 mL | |
| 15 mM | 0.6343 mL | 3.1716 mL | 6.3432 mL | 15.8579 mL | |
| 20 mM | 0.4757 mL | 2.3787 mL | 4.7574 mL | 11.8934 mL | |
| 25 mM | 0.3806 mL | 1.9029 mL | 3.8059 mL | 9.5147 mL | |
| 30 mM | 0.3172 mL | 1.5858 mL | 3.1716 mL | 7.9290 mL | |
| 40 mM | 0.2379 mL | 1.1893 mL | 2.3787 mL | 5.9467 mL | |
| 50 mM | 0.1903 mL | 0.9515 mL | 1.9029 mL | 4.7574 mL | |
| 60 mM | 0.1586 mL | 0.7929 mL | 1.5858 mL | 3.9645 mL | |
| 80 mM | 0.1189 mL | 0.5947 mL | 1.1893 mL | 2.9734 mL | |
| 100 mM | 0.0951 mL | 0.4757 mL | 0.9515 mL | 2.3787 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
2-Cyanopyrimidine 関連分類
HY-Y0241 関連分類
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