1. Metabolic Enzyme/Protease
  2. Cathepsin
  3. 2-Cyanopyrimidine


Cat. No.: HY-Y0241 Purity: 99.92%
COA Handling Instructions

2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos.

For research use only. We do not sell to patients.

2-Cyanopyrimidine Chemical Structure

2-Cyanopyrimidine Chemical Structure

CAS No. : 14080-23-0

Size Price Stock Quantity
10 mM * 1 mL in Water USD 61 Get quote
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 61 Get quote
100 mg USD 55 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos[1].

IC50 & Target

IC50: 170 nM (cysteine protease cathepsin K)[1]

In Vitro

2-Cyanopyrimidine is a 2-cyano-4-cyclohexylamino-pyrimidine derivative. Cathepsin K is a lysosomal cysteine protease[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (237.87 mM; Need ultrasonic)

DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.5147 mL 47.5737 mL 95.1475 mL
5 mM 1.9029 mL 9.5147 mL 19.0295 mL
10 mM 0.9515 mL 4.7574 mL 9.5147 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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