1. Metabolic Enzyme/Protease
  2. Cathepsin
  3. Balicatib

Balicatib (Synonyms: AAE581)

Cat. No.: HY-15100 Purity: 97.23%
Handling Instructions

Balicatib(AAE-581) is a potent and selective inhibitor of cathepsin K; 10-100 fold more potent in cell-based enzyme occupancy assays than against cathepsin B, L, and S.

For research use only. We do not sell to patients.

Balicatib Chemical Structure

Balicatib Chemical Structure

CAS No. : 354813-19-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 145 In-stock
Estimated Time of Arrival: December 31
5 mg USD 132 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Estimated Time of Arrival: December 31
100 mg USD 780 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Balicatib(AAE-581) is a potent and selective inhibitor of cathepsin K; 10-100 fold more potent in cell-based enzyme occupancy assays than against cathepsin B, L, and S. IC50 value: Target: cathepsin K The cathepsin K inhibitor AAE-581 (balicatib) as the most advanced of them passed Phase II clinical trials in 2005. Eighty adult female Macaca fascicularis underwent bilateral ovariectomies and were dosed twice daily by oral gavage with balicatib at 0, 3, 10, and 50 mg/kg for 18 months (groups O, L, M, H, respectively). Approximately 1 month after treatment initiation, the 50 mg/kg dose was decreased to 30 mg/kg. Twenty animals underwent sham-ovariectomies (group S). Bone mass was measured at 3-6 month intervals. At 18 months, vertebra and femur were collected for histomorphometry.

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 46 mg/mL (111.78 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4299 mL 12.1495 mL 24.2990 mL
5 mM 0.4860 mL 2.4299 mL 4.8598 mL
10 mM 0.2430 mL 1.2149 mL 2.4299 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

411.54

Formula

C₂₃H₃₃N₅O₂

CAS No.

354813-19-7

SMILES

CCCN1CCN(C2=CC=C(C(NC3(C(NCC#N)=O)CCCCC3)=O)C=C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Balicatib
Cat. No.:
HY-15100
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Balicatib

Cat. No.: HY-15100