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HIV+replication

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48

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1

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1

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14

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2

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1

Click Chemistry

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W037893
    CHMA1004 dihydrochloride
    2 Publications Verification

    Methyl piperazine-2-carboxylate dihydrochloride; METTL3 activator-1

    		 METTL3 HIV Infection Neurological Disease
    CHMA1004 (Methyl piperazine-2-carboxylate; METTL3 activator-1) dihydrochloride is a METTL3/METTL14/WTAP methyltransferase complex activator. CHMA1004 dihydrochloride exhibits neuroprotective and anxiolytic potential by enhancing m 6A methylation modification of RNA. CHMA1004 dihydrochloride promotes HIV replication in an infection context. CHMA1004 dihydrochloride can be used in studies related to anxiety disorders and HIV-1 infection .
    CHMA1004 dihydrochloride
  • HY-B0439
    Sulfadoxine

    Sulphadoxine

    		 Parasite HIV Antibiotic Endogenous Metabolite Infection
    Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.
    Sulfadoxine
  • HY-W013441
    2',3'-Dideoxyadenosine
    1 Publications Verification

    		 HIV Infection
    2',3'-Dideoxyadenosine is an inhibitor of HIV replication . Antiretroviral activity . Antiviral efficacy .
    2',3'-Dideoxyadenosine
  • HY-N7543
    Schisantherin D

    		HIV Endothelin Receptor Infection Metabolic Disease
    Schisantherin D is a lignan. Schisantherin D can be isolated from Kadsura interior. Schisantherin D downregulates the expression of ETBR and inhibits the secretion of ECM and ET-1. Schisantherin D alleviates EtOH + ET-1-induced hepatocyte cytotoxicity. Schisantherin D potently inhibits HIV replication in cells .
    Schisantherin D
  • HY-120427
    Cosalane
    1 Publications Verification

    NSC 658586

    		 CCR CXCR HIV HSV Infection Inflammation/Immunology
    Cosalane (NSC 658586) is a CCR7 (IC50 = 2.43 μM) and CXCR2 antagonist (IC50 = 0.66 μM). Cosalane is an inhibitor of HIV replication with a wide range of activity against HIV-1 isolates, HIV-2, Rauscher murine leukemia virus, HSV-1, HSV-2 and human cytomegalovirus. Cosalane inhibits both attachment of gp120 to CD4. Cosalane inhibits human and murine CCR7 in response to both CCL19 and CCL21 agonists. Cosalane can be studied in research for HIV or attenuating acute graft-versus-host disease (aGVHD) in allogeneic hematopoietic stem cell transplantation (HSCT) .
    Cosalane
  • HY-137697D
    ddCTP trisodium solution (100 mM)

    		HIV DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Drug Metabolite HIV Protease Infection
    ddCTP trilithium solution (100 mM) is a chain-terminating dideoxynucleotide. ddCTP trilithium is a type of chain-terminating deoxynucleotide. ddCTP trilithium can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP trilithium can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP trilithium is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication .
    ddCTP trisodium solution (100 mM)
  • HY-106850
    3′-Azido-2′,3′-dideoxyuridine

    AzdU; AzddU; CS-87

    		 HIV Infection
    3′-Azido-2′,3′-dideoxyuridine (AzdU) is a nucleoside analog of Zidovudine (HY-17413). 3′-Azido-2′,3′-dideoxyuridine is a potent inhibitor of human immunodeficiency virus (HIV) replication in human peripheral blood mononuclear cells (PBMC) with limited toxicity for human bone marrow cells (BMC) . 3′-Azido-2′,3′-dideoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    3′-Azido-2′,3′-dideoxyuridine
  • HY-137697
    ddCTP

    		Nucleoside Antimetabolite/Analog DNA/RNA Synthesis HIV Protease HIV Drug Metabolite Infection
    ddCTP is a type of chain-terminating deoxynucleotide. ddCTP can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication .
    ddCTP
  • HY-134851
    HIV-1 inhibitor-6
    1 Publications Verification

    		 HIV Infection
    HIV-1 inhibitor-6 (compound 9), a diheteroarylamide-based compound, is a potent HIV-1 pre-mRNA alternative splicing inhibitor. HIV-1 inhibitor-6 blocks HIV replication. HIV-1 inhibitor-6 is active against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC50s of 0.6 μM and 0.9 μM, respectively. HIV-1 inhibitor-6 inhibits HIV strains resistant to agents targeting HIV reverse transcriptase, protease, integrase, and coreceptor CCR5 with EC50s ranging from 0.9 to 1.5 μM .
    HIV-1 inhibitor-6
  • HY-106382
    PMEDAP

    		HIV CMV Infection Cancer
    PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality .
    PMEDAP
  • HY-100261
    CCR5 antagonist 1

    		CCR HIV Infection Endocrinology
    CCR5 antagonist 1 is a CCR5 antagonist which can inhibit HIV replication extracted from WO 2004054974 A2.
    CCR5 antagonist 1
  • HY-N9340
    Hypoglaunine D

    		HIV Infection
    Hypoglaunine D is an analogue of Triptonine B and acts as an anti-HIV compound. Hypoglaunine D inhibits HIV replication in H9 lymphocytes with an EC50 value of 22 μg/ml .
    Hypoglaunine D
  • HY-N12125
    Entadamide A

    		Others Infection
    Entadamide A (compound 1) is a tryptophan derivative. Entadamide A prevents tryptophan depletion by inhibiting indoleamine 2, 3-dioxygenase (IDO), thereby inhibiting HIV replication. Entadamide A can be used in drug and neuropsychiatric studies of redesivir [1].
    Entadamide A
  • HY-B0439S1
    Sulfadoxine D3

    Sulphadoxine d3

    		 Parasite Antibiotic Infection
    Sulfadoxine-d3 is a deuterium labeled Sulfadoxine (HY-B0439). Sulfadoxine is a sulfonamide that is used, usually in combination with Pyrimethamine(HY-18062), for multidrug-resistant Plasmodium falciparum and P. vivax inhibition. Unlike PYR, Sulfadoxine has no impact on HIV replication or MT-2 cell cycle progression. But also Sulfadoxine exhibits suppression on respiratory, and urinary tract infections .
    Sulfadoxine D3
  • HY-N8361
    Glycoborinine

    		HIV Apoptosis Infection Cancer
    Glycoborinine, a natural carbazole alkaloid, can be isolated from Glycosmis pentaphylla. Glycoborinine induces HepG2 cell apoptosis through mitochondrial pathway. Glycoborinine also inhibits HIV replication in cells .
    Glycoborinine
  • HY-178201
    JLJ648

    		HIV Pyroptosis Infection
    JLJ648 is a Gag-Pol dimerizer with antiviral activity. JLJ648 can inhibit HIV replication and induce infected cell pyroptosis. JLJ648 can be used for the research of infection, such as HIV (human immunodeficiency virus) .
    JLJ648
  • HY-W105741
    12-Bromododecanoic acid

    		HIV Infection
    12-Bromododecanoic acid is a bromo fatty acid. 12-Bromododecanoic acid can be used in the synthesis of clickable forms of myristic acid. 12-Bromododecanoic acid inhibits HIV replication in CEM-SS T cells (EC50 = 38 µM) .
    12-Bromododecanoic acid
  • HY-B0439R
    Sulfadoxine (Standard)

    Sulphadoxine (Standard)

    		 Reference Standards Parasite HIV Antibiotic Endogenous Metabolite Infection
    Sulfadoxine (Standard) is the analytical standard of Sulfadoxine. This product is intended for research and analytical applications. Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.
    Sulfadoxine (Standard)
  • HY-16658C
    Z-VA-DL-D-FMK

    Z-VA-DL-D(OH)-FMK

    		 Caspase Infection
    Z-VA-DL-D-FMK (Z-VA-DL-D(OH)-FMK) is an inhibitor for caspase . Z-VA-DL-D-FMK binds irreversibly to caspases, increases the sensitivity of TNF-α, and activates HIV replication in infected T cell ACH-2 .
    Z-VA-DL-D-FMK
  • HY-139158
    Ainuovirine

    		HIV Infection
    Ainuovirine is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI). Ainuovirine inhibits HIV replication by non-competitively binding to HIV reverse transcriptase and blocking the reverse transcription process of viral RNA. Ainuovirine can be used for human immunodeficiency virus (HIV) type 1 infection .
    Ainuovirine
  • HY-W125425
    CHMA1004

    Methyl piperazine-2-carboxylate; METTL3 activator-1 free base

    		 METTL3 HIV Infection Neurological Disease
    CHMA1004 (Methyl piperazine-2-carboxylate; METTL3 activator-1 free base) is a METTL3/METTL14/WTAP methyltransferase complex activator . CHMA1004 exhibits neuroprotective and anxiolytic potential by enhancing m 6A methylation modification of RNA. CHMA1004 promotes HIV replication in an infection context. CHMA1004 can be used in studies related to anxiety disorders and HIV-1 infection .
    CHMA1004
  • HY-15350
    Trovirdine hydrochloride

    LY 300046 hydrochloride

    		 Reverse Transcriptase Others
    Trovirdine hydrochloride, a phenethylthiazolylthiourea (PETT) derivative, is an HIV reverse transcriptase (RT) non-nucleoside inhibitor (NNI). A novel computer model of the RT/NNI binding pocket revealed spatial gaps around Trovirdine hydrochloride's pyridyl ring. Docking studies suggested that replacing this planar ring with a nonplanar piperidinyl or piperazinyl ring could better occupy the binding pocket, enhancing anti-HIV activity. Synthesized heterocyclic compounds based on this modification demonstrated greater potency than Trovirdine hydrochloride, effectively inhibiting HIV replication at nanomolar concentrations without cytotoxicity in infected peripheral blood mononuclear cells .
    Trovirdine hydrochloride
  • HY-N3700
    Decarine

    Rutaceline

    		 Bacterial HIV TNF Receptor Interleukin Related Infection Inflammation/Immunology
    Decarine (Rutaceline) is a benzophenanthridine alkaloid found in Zanthoxylum species. Decarinewith shows anti-inflammatory, antimycobacterial, and anti-HIV activity. Decarine inhibits NO, TNF-α, IL-1β, IL-6, and IL-8 production in inflammatory cell models. Decarine inhibits growth of Mycobacterium tuberculosis strains, reduces intracellular Mycobacterium tuberculosis survival, and shows low cytotoxicity toward human macrophages. Decarine inhibits HIV replication in acutely infected lymphocytes. Decarine can be used for the researches of inflammation, tuberculosis, and HIV infection .
    Decarine
  • HY-137697B
    ddCTP trilithium

    		HIV DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Drug Metabolite HIV Protease Infection
    ddCTP trilithium is a type of chain-terminating deoxynucleotide. ddCTP trilithium can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP trilithium can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP trilithium is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication .
    ddCTP trilithium
  • HY-121718
    DQBS

    		HIV Infection
    DQBS can bind to HIV-1 nef protein, and inhibits Nef-dependent HIV replication .
    DQBS
  • HY-N8368
    Neotripterifordin

    		HIV Infection
    Neotripterifordin is a inhibitor of HIV. Neotripterifordin has anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 25 nM .
    Neotripterifordin
  • HY-N12082
    HIV-IN-8

    		HIV Infection
    HIV-IN-8 (Compound 9) is a HIV inhibitor. HIV-IN-8 inhibits HIV replication with an EC50 of 13 μg/mL .
    HIV-IN-8
  • HY-107142
    RM-5038

    		HIV Infection
    RM-5038 is a thiazolide antivirus agent. RM-5038 can induce innate immunity and reduce HIV replication .
    RM-5038
  • HY-W714002
    Feglymycin

    		HIV Bacterial Infection
    Feglymycin is a HIV replication inhibitor. Feglymycin is also an antibiotic peptide that has antibacterial activity (MIC: 32-64 μg/mL for Staphylococcus aureus) .
    Feglymycin
  • HY-N6080
    Tripterifordin

    		HIV Infection
    Tripterifordin possesses significant anti-HIV replication activities in H9 lymphocyte cells with an EC50 value of 3100 nM, respectively .
    Tripterifordin
  • HY-N3511
    Triptonine B

    		HIV Infection
    Triptonine B, a sesquiterpene pyridine alkaloid, inhibits HIV replication in H9 lymphocytes with an EC50 value of <0.10 μg/mL .
    Triptonine B
  • HY-127078
    Salaspermic acid

    		HIV Others
    Salaspermic acid is a new triterpene acid isolated from Salacia macrosperma Wight. Salaspermic acid is an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells .
    Salaspermic acid
  • HY-122786
    3-O-Methylviridicatin

    		Antibiotic HIV Infection
    3-O-Methylviridicatin is an indole alkaloid. 3-O-Methylviridicatin inhibits TNF-alpha induced HIV replication with an IC50 of 2.5 μM .
    3-O-Methylviridicatin
  • HY-174634
    Human IL16 mRNA

    		mRNA Inflammation/Immunology
    Human IL16 mRNA encodes the human interleukin 16 (IL16) protein, a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication.
    Human IL16 mRNA
  • HY-117434
    Suberosol

    		HIV Infection
    Suberosol, a C31 lanostane-type triterpene, is an anti-HIV drug. Suberosol shows anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 3 μg/mL .
    Suberosol
  • HY-N6849
    InteriotherinA

    		HIV Infection Metabolic Disease
    Interiotherin A is a lignan with a dibenzocyclooctadiene skeleton isolated from Kadsura interior. Interiotherin A inhibits HIV replication to exhibit anti-HIV activity, it has a role as a metabolite and an anti-HIV agent .
    InteriotherinA
  • HY-134180
    rel-Carbovir monophosphate

    		HIV Infection
    rel-Carbovir monophosphate is the -enantiomer of 2',3'-dideoxy-2',3'-didehydroguanosine and a carbocyclic analog of carbovir (CBV). Carbovir is an inhibitor of HIV replication that specifically inhibits the integration of proribonucleotides into DNA .
    rel-Carbovir monophosphate
  • HY-B0439S
    Sulfadoxine-d4

    Sulphadoxine-d4

    		 Parasite HIV Antibiotic Endogenous Metabolite Infection
    Sulfadoxine-d4 is the deuterium labeled Sulfadoxine. Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.
    Sulfadoxine-d4
  • HY-W013441R
    2',3'-Dideoxyadenosine (Standard)

    		Reference Standards HIV Infection
    2',3'-Dideoxyadenosine (Standard) is the analytical standard of 2',3'-Dideoxyadenosine. This product is intended for research and analytical applications. 2',3'-Dideoxyadenosine is an inhibitor of HIV replication . Antiretroviral activity . Antiviral efficacy .
    2',3'-Dideoxyadenosine (Standard)
  • HY-115828
    APA-APA-MPO dihydrochloride

    		HIV Infection
    APA-APA-MPO dihydrochloride is an inhibitor of PCAF bromodomain/Tat-AcK50 interaction with reduced cytotoxic activity. APA-APA-MPO dihydrochloride can effectively inhibit the binding of PCAF to Tat-AcK50, showing its potential in HIV/AIDS inhibitory strategies. APA-APA-MPO dihydrochloride can be used in studies that hinder HIV replication .
    APA-APA-MPO dihydrochloride
  • HY-115829
    APA-H-MPO hydrochloride

    		HIV Infection
    APA-H-MPO hydrochloride is an inhibitor of PCAF bromodomain/Tat-AcK50 interaction with potential for anti-HIV/AIDS. APA-H-MPO hydrochloride can effectively inhibit the binding of PCAF bromodomain to Tat-AcK50. APA-H-MPO hydrochloride showed low cytotoxicity in preliminary cell studies. APA-H-MPO hydrochloride is considered a potential candidate for a promising inhibitory strategy targeting the host cell protein PCAF BRD to block HIV replication .
    APA-H-MPO hydrochloride
  • HY-116240
    2′,3′-Dideoxy-5-ethyluridine

    ddEtUrd

    		 HIV Infection
    2′,3′-Dideoxy-5-ethyluridine (ddEtUrd) is an antiretroviral compound with weak anti-HIV activity. The 3'-substituted derivatives of 2′,3′-Dideoxy-5-ethyluridine did not show significant antiviral effects. 2′,3′-Dideoxy-5-ethyluridine was less potent in inhibiting HIV replication in human MT4 lymphocytes. Although phosphorylation induced by 2′,3′-Dideoxy-5-ethyluridine is essential for antiviral activity, there is no strong correlation between its affinity for human dThd kinase or dCyd kinase .
    2′,3′-Dideoxy-5-ethyluridine
  • HY-106942
    CGP 53437

    		HIV Virus Protease Infection
    CGP 53437 is an orally active HIV-1 protease inhibitor, with a Ki of 0.2 nM. CGP 53437 delays the onset of HIV replication .
    CGP 53437
  • HY-19493
    Niglizin

    		Reverse Transcriptase HIV Infection
    Niglizin is a noncompetitive inhibitor of reverse transcriptase. Niglizin can effectively suppress the HIV replication and shows synergetic effect companied with Zidovudine (HY-17413). Niglizin can be used for the research of HIV infection .
    Niglizin
  • HY-N17557
    Schizanrin D

    Schizarin D

    		 HBV HIV Infection
    Schizanrin D (Schizarin D) is a C18 Dibenzocyclooctadiene lignin. Schizanrin D can be derived from dried stems of Kadsura matsudai. Schizanrin D inhibits HBeAg production. Schizanrin D is inactive in vitro against HIV replication .
    Schizanrin D
  • HY-106382R
    PMEDAP (Standard)

    		Reference Standards HIV CMV Infection Cancer
    PMEDAP (Standard) is the analytical standard of PMEDAP (HY-106382). This product is intended for research and analytical applications. PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality .
    PMEDAP (Standard)
  • HY-137697A
    ddCTP tetrasodium

    		Drug Metabolite HIV Nucleoside Antimetabolite/Analog HIV Protease DNA/RNA Synthesis Infection
    ddCTP tetrasodium is a type of chain-terminating deoxynucleotide. ddCTP tetrasodium can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP tetrasodium can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP tetrasodium is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication .
    ddCTP tetrasodium
  • HY-182277
    GSK-1264

    		HIV Integrase HIV Infection
    GSK-1264 is an HIV-1 integrase inhibitor. GSK-1264 binds to a site spanning the HIV-1 integrase catalytic core domain and C-terminal domain, mediates formation of an open polymer of HIV-1 integrase dimers via inhibitor-bridged contacts between adjacent dimers. GSK-1264 disrupts late-stage HIV replication by interfering with viral particle assembly. GSK-1264 stimulates inappropriate polymerization of HIV-1 integrase. GSK-1264 can be used for the research of HIV infection .
    GSK-1264

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