1. Anti-infection
  2. HIV CMV
  3. PMEDAP

PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality.

For research use only. We do not sell to patients.

PMEDAP Chemical Structure

PMEDAP Chemical Structure

CAS No. : 113852-41-8

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Based on 1 publication(s) in Google Scholar

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Description

PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality[1][2].

In Vivo

PMEDAP (0.25-5 mg/kg; IP; daily; starting on the day of MSV-infected and continuing for an additional four days) causes a dose-dependent suppression of tumor formation and mortality in newborn mice inoculated with MSV[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Three-week-old male NMRI mice[1]
Dosage: 0.25 mg/kg, 1 mg/kg, 5 mg/kg
Administration: IP; daily; starting on the day of infection and continuing for an additional four days
Result: Effected a significant delay in tumor appearance and an enhancement of the survival rate of tumor-bearing mice.
Molecular Weight

288.20

Formula

C8H13N6O4P

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(COCCN1C=NC2=C1N=C(N)N=C2N)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

0.1 M NaOH : 14.29 mg/mL (49.58 mM; ultrasonic and adjust pH to 12 with NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4698 mL 17.3491 mL 34.6981 mL
5 mM 0.6940 mL 3.4698 mL 6.9396 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
0.1 M NaOH 1 mM 3.4698 mL 17.3491 mL 34.6981 mL 86.7453 mL
5 mM 0.6940 mL 3.4698 mL 6.9396 mL 17.3491 mL
10 mM 0.3470 mL 1.7349 mL 3.4698 mL 8.6745 mL
15 mM 0.2313 mL 1.1566 mL 2.3132 mL 5.7830 mL
20 mM 0.1735 mL 0.8675 mL 1.7349 mL 4.3373 mL
25 mM 0.1388 mL 0.6940 mL 1.3879 mL 3.4698 mL
30 mM 0.1157 mL 0.5783 mL 1.1566 mL 2.8915 mL
40 mM 0.0867 mL 0.4337 mL 0.8675 mL 2.1686 mL
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PMEDAP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PMEDAP
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HY-106382
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