113852-41-8
113852-41-8
Chemical Structure
PMEDAP
- CAS No.: 113852-41-8
- Formula:C8H13N6O4P
- Molecular Weight:288.20
IUPAC Name: ((2-(2,6-diamino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid
InChIKey: XHXFQGAZAVKMFF-UHFFFAOYSA-N
SMILES: O=P(O)(COCCN1C=NC2=C1N=C(N)N=C2N)O
Biological Activity: PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PMEDAP | 98.0% | PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality. | ||||||||||||||||||||
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PMEDAP (Standard) | ≥98% | PMEDAP (Standard) is the analytical standard of PMEDAP (HY-106382). This product is intended for research and analytical applications. PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality. | ||||||||||||||||||||
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References
- [1]. Neyts J, et al. Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo [published correction appears in Eur J Clin Microbiol Infect Dis 1993 Jul;12(7):following 477]. Eur J Clin Microbiol Infect Dis. 1993;12(6):437-446. [Content Brief]
- [2]. Naesens L, et al. 9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo. Eur J Clin Microbiol Infect Dis. 1989;8(12):1043-1047. [Content Brief]
