Schizanrin D (Synonyms: Schizarin D)

Cat. No.: HY-N17557: Data Sheet Handling Instructions
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Schizanrin D (Schizarin D) is a C₁₈ Dibenzocyclooctadiene lignin. Schizanrin D can be derived from dried stems of Kadsura matsudai. Schizanrin D inhibits HBeAg production. Schizanrin D is inactive in vitro against HIV replication.

For research use only. We do not sell to patients.

Schizanrin D Chemical Structure

CAS No. : 343326-65-8

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Description

In Vitro

Schizanrin D (10-20 μg/mL; 3 days) inhibits HBeAg production in MS-G2 cells at 10 μg/mL (20.6 μM) with a 25.8% decrease but is cytotoxic at 20 μg/mL (41.3 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:	MS-G2 cells (HBV DNA-integrated hepatoblastoma-derived cell line)
Concentration:	10 μg/mL (20.6 μM); 20 μg/mL (41.3 μM)
Incubation Time:	3 days
Result:	Inhibited HBeAg production with a 25.8% decrease at 10 μg/mL (20.6 μM); Caused cytotoxicity with an AST value of 47.8 IU/L (indicating cell damage) at 20 μg/mL (41.3 μM).

Molecular Weight

484.54

Formula

C₂₇H₃₂O₈

CAS No.

343326-65-8

SMILES

C/C=C(C)/C(O[C@H]1[C@H](C)[C@H](C)CC2=CC(OC)=C(OC)C(OC)=C2C3=C1C=C4OCOC4=C3O)=O

Structure Classification

Initial Source

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kuo YH, et al. Schizanrins [corrected] B, C, D, and E, four new lignans from Kadsura matsudai and their antihepatitis activities. J Nat Prod. 2001 Apr;64(4):487-90. [Content Brief]

Schizanrin D Related Classifications

Infection

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Schizanrin D343326-65-8Schizarin DHBVHIVHepatitis B virusHuman immunodeficiency virushuman type B hepatitis e antigenMS-G2 cellsKadsura matsudai HayataHBeAghuman type B hepatitiscancer cellsASTInhibitorinhibitorinhibit

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